CS207459B2 - Method of making the neutralization antiacidic means - Google Patents

Method of making the neutralization antiacidic means Download PDF

Info

Publication number: CS207459B2
Authority: CS; Czechoslovakia
Prior art keywords: acid; polyethyleneimine; aqueous solution; amount; water
Prior art date: 1976-06-03

Application number

CS773612A

Other languages

Czech (cs)

English (en)

Inventor

Conny B Bogentoft

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-06-03

Filing date

1977-06-01

Publication date

1981-07-31

1977-06-01 Application filed by Haessle Ab filed Critical Haessle Ab

1981-07-31 Publication of CS207459B2 publication Critical patent/CS207459B2/cs

Links

238000004519 manufacturing process Methods 0.000 title claims abstract description 4
238000006386 neutralization reaction Methods 0.000 title description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 36
229920002873 Polyethylenimine Polymers 0.000 claims abstract description 27
239000002253 acid Substances 0.000 claims abstract description 23
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 18
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 18
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 13
239000000783 alginic acid Substances 0.000 claims abstract description 13
235000010443 alginic acid Nutrition 0.000 claims abstract description 13
229960001126 alginic acid Drugs 0.000 claims abstract description 13
229920000615 alginic acid Polymers 0.000 claims abstract description 13
150000004781 alginic acids Chemical class 0.000 claims abstract description 13
239000007864 aqueous solution Substances 0.000 claims abstract description 13
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 10
229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 9
229920002230 Pectic acid Polymers 0.000 claims abstract description 8
230000003472 neutralizing effect Effects 0.000 claims abstract description 8
239000010318 polygalacturonic acid Substances 0.000 claims abstract description 8
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract description 7
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 6
QXKAIJAYHKCRRA-JJYYJPOSSA-N D-arabinonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(O)=O QXKAIJAYHKCRRA-JJYYJPOSSA-N 0.000 claims abstract description 6
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 6
210000004211 gastric acid Anatomy 0.000 claims abstract description 6
239000001630 malic acid Substances 0.000 claims abstract description 6
235000011090 malic acid Nutrition 0.000 claims abstract description 6
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims abstract description 5
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract description 5
DSLZVSRJTYRBFB-UHFFFAOYSA-N Galactaric acid Natural products OC(=O)C(O)C(O)C(O)C(O)C(O)=O DSLZVSRJTYRBFB-UHFFFAOYSA-N 0.000 claims abstract description 5
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 5
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims abstract description 5
239000001530 fumaric acid Substances 0.000 claims abstract description 5
DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 claims abstract description 5
239000011975 tartaric acid Substances 0.000 claims abstract description 5
235000002906 tartaric acid Nutrition 0.000 claims abstract description 5
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 5
239000001814 pectin Substances 0.000 claims abstract description 4
235000010987 pectin Nutrition 0.000 claims abstract description 4
229920001277 pectin Polymers 0.000 claims abstract description 4
239000007788 liquid Substances 0.000 claims abstract description 3
AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims abstract 2
239000000203 mixture Substances 0.000 claims description 12
235000011054 acetic acid Nutrition 0.000 claims description 11
230000001458 anti-acid effect Effects 0.000 claims description 8
235000011007 phosphoric acid Nutrition 0.000 claims description 8
235000015165 citric acid Nutrition 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
239000001384 succinic acid Substances 0.000 claims description 5
235000011044 succinic acid Nutrition 0.000 claims description 5
235000011087 fumaric acid Nutrition 0.000 claims description 4
239000001648 tannin Substances 0.000 claims description 4
235000018553 tannin Nutrition 0.000 claims description 4
229920001864 tannin Polymers 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
150000007513 acids Chemical class 0.000 claims description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract description 6
239000003159 antacid agent Substances 0.000 abstract description 5
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract description 3
TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 abstract 1
239000001263 FEMA 3042 Substances 0.000 abstract 1
LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 abstract 1
LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 abstract 1
229940033123 tannic acid Drugs 0.000 abstract 1
235000015523 tannic acid Nutrition 0.000 abstract 1
229920002258 tannic acid Polymers 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
238000006243 chemical reaction Methods 0.000 description 9
238000009472 formulation Methods 0.000 description 9
238000002360 preparation method Methods 0.000 description 8
239000000243 solution Substances 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
239000004098 Tetracycline Substances 0.000 description 2
235000019621 digestibility Nutrition 0.000 description 2
239000003814 drug Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000012669 liquid formulation Substances 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
229940040944 tetracyclines Drugs 0.000 description 2
208000005223 Alkalosis Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
206010020601 Hyperchlorhydria Diseases 0.000 description 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
208000021386 Sjogren Syndrome Diseases 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
239000000159 acid neutralizing agent Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000002340 alkalosis Effects 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
229940069428 antacid Drugs 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000027119 gastric acid secretion Effects 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000002475 laxative effect Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
150000002681 magnesium compounds Chemical class 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000002245 particle Substances 0.000 description 1
-1 peiktim Polymers 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Control Of Combustion (AREA)
Manufacturing Of Printed Circuit Boards (AREA)

CS773612A 1976-06-03 1977-06-01 Method of making the neutralization antiacidic means CS207459B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE7606256A SE405445B (sv)	1976-06-03	1976-06-03	Forfarande for framstellning av ett magsyreneutraliserande antacidum i flytande form innehallande polyetylenimin

Publications (1)

Publication Number	Publication Date
CS207459B2 true CS207459B2 (en)	1981-07-31

Family

ID=20328121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS773612A CS207459B2 (en)	1976-06-03	1977-06-01	Method of making the neutralization antiacidic means

Country Status (21)

Country	Link
JP (1)	JPS52148630A (fr)
AT (1)	AT353406B (fr)
AU (1)	AU514929B2 (fr)
BE (1)	BE855349A (fr)
CA (1)	CA1087094A (fr)
CS (1)	CS207459B2 (fr)
DD (1)	DD131345A5 (fr)
DE (1)	DE2722486A1 (fr)
DK (1)	DK234077A (fr)
FI (1)	FI59023C (fr)
FR (1)	FR2353296A1 (fr)
GB (1)	GB1539162A (fr)
HU (1)	HU174584B (fr)
IE (1)	IE45208B1 (fr)
LU (1)	LU77480A1 (fr)
NL (1)	NL7706085A (fr)
NO (1)	NO771899L (fr)
NZ (1)	NZ184237A (fr)
SE (1)	SE405445B (fr)
SU (1)	SU812156A3 (fr)
ZA (1)	ZA772913B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5936192B2 (ja) *	2012-10-25	2016-06-15	学校法人神奈川大学	キラル超分子結晶及びそれからなる固体触媒、並びにキラル超分子結晶の製造方法

1976
- 1976-06-03 SE SE7606256A patent/SE405445B/xx unknown
1977
- 1977-05-16 ZA ZA00772913A patent/ZA772913B/xx unknown
- 1977-05-18 DE DE19772722486 patent/DE2722486A1/de not_active Withdrawn
- 1977-05-24 FI FI771660A patent/FI59023C/fi not_active IP Right Cessation
- 1977-05-27 DK DK234077A patent/DK234077A/da unknown
- 1977-05-30 NZ NZ184237A patent/NZ184237A/xx unknown
- 1977-05-30 AU AU25612/77A patent/AU514929B2/en not_active Expired
- 1977-05-31 IE IE1120/77A patent/IE45208B1/en unknown
- 1977-05-31 NO NO771899A patent/NO771899L/no unknown
- 1977-06-01 DD DD7700199241A patent/DD131345A5/xx unknown
- 1977-06-01 CS CS773612A patent/CS207459B2/cs unknown
- 1977-06-01 HU HU77HE737A patent/HU174584B/hu unknown
- 1977-06-02 SU SU772490602A patent/SU812156A3/ru active
- 1977-06-02 FR FR7716916A patent/FR2353296A1/fr active Granted
- 1977-06-02 NL NL7706085A patent/NL7706085A/xx not_active Application Discontinuation
- 1977-06-02 CA CA279,734A patent/CA1087094A/fr not_active Expired
- 1977-06-02 GB GB23486/77A patent/GB1539162A/en not_active Expired
- 1977-06-03 JP JP6568177A patent/JPS52148630A/ja active Pending
- 1977-06-03 AT AT393877A patent/AT353406B/de not_active IP Right Cessation
- 1977-06-03 LU LU77480A patent/LU77480A1/xx unknown
- 1977-06-03 BE BE178155A patent/BE855349A/fr unknown

Also Published As

Publication number	Publication date
CA1087094A (fr)	1980-10-07
AU514929B2 (en)	1981-03-05
DD131345A5 (de)	1978-06-21
DE2722486A1 (de)	1977-12-22
AU2561277A (en)	1978-12-07
FR2353296B1 (fr)	1981-01-16
NO771899L (no)	1977-12-06
FI771660A7 (fr)	1977-12-04
ATA393877A (de)	1979-04-15
IE45208L (en)	1977-12-03
NZ184237A (en)	1979-10-25
HU174584B (hu)	1980-02-28
FR2353296A1 (fr)	1977-12-30
AT353406B (de)	1979-11-12
LU77480A1 (fr)	1978-01-26
NL7706085A (nl)	1977-12-06
SE7606256L (sv)	1977-12-04
SU812156A3 (ru)	1981-03-07
IE45208B1 (en)	1982-07-14
GB1539162A (en)	1979-01-31
FI59023B (fi)	1981-02-27
DK234077A (da)	1977-12-04
FI59023C (fi)	1981-06-10
ZA772913B (en)	1978-04-26
BE855349A (fr)	1977-12-05
JPS52148630A (en)	1977-12-10
SE405445B (sv)	1978-12-11

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