CS207482B1 - method of making the crystalographically pure polymerous form of the cimetidine - Google Patents

method of making the crystalographically pure polymerous form of the cimetidine Download PDF

Info

Publication number: CS207482B1
Authority: CS; Czechoslovakia
Prior art keywords: cimetidine; suspension; pure; crystalographically; polymerous
Prior art date: 1976-09-21

Application number

CS611677A

Other languages

Czech (cs)

English (en)

Inventor

Partrick M G Bavin

James Ch P Sly

Geoffrey D Tovey

Richard J Ward

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-21

Filing date

1977-09-21

Publication date

1981-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10407431&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS207482(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1976-09-21 Priority claimed from GB3906576A external-priority patent/GB1543238A/en

1977-09-21 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1981-07-31 Publication of CS207482B1 publication Critical patent/CS207482B1/cs

Links

CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title claims description 46
229960001380 cimetidine Drugs 0.000 title claims description 43
238000004519 manufacturing process Methods 0.000 title description 5
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 16
239000000725 suspension Substances 0.000 claims description 15
238000000034 method Methods 0.000 claims description 11
239000002904 solvent Substances 0.000 claims description 8
238000012546 transfer Methods 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 2
238000005119 centrifugation Methods 0.000 claims description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
239000007787 solid Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
238000001816 cooling Methods 0.000 description 4
238000002425 crystallisation Methods 0.000 description 4
230000008025 crystallization Effects 0.000 description 4
238000002329 infrared spectrum Methods 0.000 description 4
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 3
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 3
239000000047 product Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
-1 (5-methyl-4-imidazolyl) methylthio Chemical group 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
238000013019 agitation Methods 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000035515 penetration Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
238000005147 X-ray Weissenberg Methods 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000007405 data analysis Methods 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000012020 french fries Nutrition 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000000227 grinding Methods 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000010355 oscillation Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000009987 spinning Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CS611677A 1976-09-21 1977-09-21 method of making the crystalographically pure polymerous form of the cimetidine CS207482B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB3906576A GB1543238A (en)	1976-09-21	1976-09-21	Polymorph of cimetidine

Publications (1)

Publication Number	Publication Date
CS207482B1 true CS207482B1 (en)	1981-07-31

Family

ID=10407431

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS611677A CS207482B1 (en)	1976-09-21	1977-09-21	method of making the crystalographically pure polymerous form of the cimetidine

Country Status (18)

Country	Link
JP (1)	JPS60185767A (de)
AR (1)	AR218267A1 (de)
BG (1)	BG28050A3 (de)
CS (1)	CS207482B1 (de)
DD (1)	DD129906A5 (de)
DK (1)	DK417677A (de)
ES (1)	ES462517A1 (de)
FI (1)	FI772542A7 (de)
GR (1)	GR61173B (de)
IT (1)	IT1086352B (de)
MY (1)	MY8400026A (de)
NL (1)	NL7710354A (de)
NO (1)	NO773225L (de)
PL (1)	PL103681B1 (de)
PT (1)	PT66927B (de)
SE (1)	SE7710518L (de)
ZA (1)	ZA774857B (de)
ZM (1)	ZM7077A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
GB1531221A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for preparing guanidine derivatives

1977
- 1977-04-18 DD DD7700198451A patent/DD129906A5/de unknown
- 1977-05-13 GR GR53452A patent/GR61173B/el unknown
- 1977-05-17 BG BG036338A patent/BG28050A3/xx unknown
- 1977-08-11 ZA ZA00774857A patent/ZA774857B/xx unknown
- 1977-08-16 PT PT66927A patent/PT66927B/pt unknown
- 1977-08-26 FI FI772542A patent/FI772542A7/fi unknown
- 1977-09-08 IT IT27402/77A patent/IT1086352B/it active
- 1977-09-12 ZM ZM7770A patent/ZM7077A1/xx unknown
- 1977-09-19 AR AR269254A patent/AR218267A1/es active
- 1977-09-20 SE SE7710518A patent/SE7710518L/xx not_active Application Discontinuation
- 1977-09-20 NO NO773225A patent/NO773225L/no unknown
- 1977-09-20 PL PL1977200960A patent/PL103681B1/pl unknown
- 1977-09-21 DK DK417677A patent/DK417677A/da not_active Application Discontinuation
- 1977-09-21 CS CS611677A patent/CS207482B1/cs unknown
- 1977-09-21 ES ES462517A patent/ES462517A1/es not_active Expired
- 1977-09-21 NL NL7710354A patent/NL7710354A/xx not_active Application Discontinuation
1984
- 1984-07-31 JP JP59162761A patent/JPS60185767A/ja active Granted
- 1984-12-30 MY MY26/84A patent/MY8400026A/xx unknown

Also Published As

Publication number	Publication date
ES462517A1 (es)	1978-07-01
PT66927A (en)	1977-09-01
JPS6234759B2 (de)	1987-07-28
GR61173B (en)	1978-10-03
NL7710354A (nl)	1978-03-23
AR218267A1 (es)	1980-05-30
PT66927B (en)	1979-03-13
DD129906A5 (de)	1978-02-15
PL200960A1 (pl)	1978-05-22
FI772542A7 (de)	1977-08-29
NO773225L (no)	1978-03-22
MY8400026A (en)	1984-12-31
PL103681B1 (pl)	1979-07-31
JPS60185767A (ja)	1985-09-21
ZM7077A1 (en)	1978-08-21
BG28050A3 (bg)	1980-02-25
SE7710518L (sv)	1978-03-22
ZA774857B (en)	1978-06-28
IT1086352B (it)	1985-05-28
DK417677A (da)	1978-03-22

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