CS207784B2 - Method of making the solid substances with the phepharnate contents - Google Patents

Method of making the solid substances with the phepharnate contents Download PDF

Info

Publication number: CS207784B2
Authority: CS; Czechoslovakia
Prior art keywords: gefarnate; carrier; solid; magnesium; pka
Prior art date: 1978-03-14

Application number

CS791652A

Other languages

Czech (cs)

English (en)

Inventor

Muneo Hara

Terutsugu Tsuji

Ketichi Matsuda

Tadashi Umezu

Munetoshi Adachi

Original Assignee

Angeli Inst Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-03-14

Filing date

1979-03-13

Publication date

1981-08-31

1979-03-13 Application filed by Angeli Inst Spa filed Critical Angeli Inst Spa

1981-08-31 Publication of CS207784B2 publication Critical patent/CS207784B2/cs

Links

239000007787 solid Substances 0.000 title claims abstract description 33
239000000126 substance Substances 0.000 title claims description 4
238000004519 manufacturing process Methods 0.000 title description 8
239000003795 chemical substances by application Substances 0.000 claims abstract description 16
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 15
ZPACYDRSPFRDHO-ROBAGEODSA-N Gefarnate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(=O)OC\C=C(/C)CCC=C(C)C ZPACYDRSPFRDHO-ROBAGEODSA-N 0.000 claims abstract description 8
229920001386 Gefarnate Polymers 0.000 claims abstract description 8
229960003779 gefarnate Drugs 0.000 claims abstract description 8
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims abstract description 7
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims abstract description 6
239000000391 magnesium silicate Substances 0.000 claims abstract description 6
229910052919 magnesium silicate Inorganic materials 0.000 claims abstract description 6
235000019792 magnesium silicate Nutrition 0.000 claims abstract description 6
239000000395 magnesium oxide Substances 0.000 claims abstract description 5
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 5
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 5
239000001509 sodium citrate Substances 0.000 claims abstract description 4
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 4
150000005846 sugar alcohols Chemical class 0.000 claims abstract description 4
GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims abstract description 3
229960001545 hydrotalcite Drugs 0.000 claims abstract description 3
229910001701 hydrotalcite Inorganic materials 0.000 claims abstract description 3
239000000203 mixture Substances 0.000 claims description 19
238000000034 method Methods 0.000 claims description 8
238000009472 formulation Methods 0.000 claims description 7
229940024546 aluminum hydroxide gel Drugs 0.000 claims description 6
241000220479 Acacia Species 0.000 claims description 4
235000010643 Leucaena leucocephala Nutrition 0.000 claims description 4
230000002378 acidificating effect Effects 0.000 claims description 3
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 3
150000002772 monosaccharides Chemical class 0.000 claims description 3
150000002016 disaccharides Chemical class 0.000 claims description 2
230000007935 neutral effect Effects 0.000 claims description 2
239000002671 adjuvant Substances 0.000 claims 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract description 4
235000010489 acacia gum Nutrition 0.000 abstract description 4
229920002451 polyvinyl alcohol Polymers 0.000 abstract description 4
229920000084 Gum arabic Polymers 0.000 abstract description 2
239000000205 acacia gum Substances 0.000 abstract description 2
241000978776 Senegalia senegal Species 0.000 abstract 1
229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 description 7
239000000843 powder Substances 0.000 description 7
239000000969 carrier Substances 0.000 description 5
239000002904 solvent Substances 0.000 description 5
GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
239000002775 capsule Substances 0.000 description 4
230000015556 catabolic process Effects 0.000 description 4
238000006731 degradation reaction Methods 0.000 description 4
238000001035 drying Methods 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
239000008101 lactose Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 2
GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 2
239000005792 Geraniol Substances 0.000 description 2
239000001785 acacia senegal l. willd gum Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
-1 diasaccharides Chemical class 0.000 description 2
230000000694 effects Effects 0.000 description 2
229940113087 geraniol Drugs 0.000 description 2
HZZOEADXZLYIHG-UHFFFAOYSA-N magnesiomagnesium Chemical compound [Mg][Mg] HZZOEADXZLYIHG-UHFFFAOYSA-N 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
239000008247 solid mixture Substances 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
229940069428 antacid Drugs 0.000 description 1
239000003159 antacid agent Substances 0.000 description 1
230000001458 anti-acid effect Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
229910052909 inorganic silicate Inorganic materials 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
150000002681 magnesium compounds Chemical class 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
239000003921 oil Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS791652A 1978-03-14 1979-03-13 Method of making the solid substances with the phepharnate contents CS207784B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP53029746A JPS6026093B2 (ja)	1978-03-14	1978-03-14	ゲフアルナート含有固型製剤の製造方法

Publications (1)

Publication Number	Publication Date
CS207784B2 true CS207784B2 (en)	1981-08-31

Family

ID=12284653

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS791652A CS207784B2 (en)	1978-03-14	1979-03-13	Method of making the solid substances with the phepharnate contents

Country Status (17)

Country	Link
JP (1)	JPS6026093B2 (xx)
AR (1)	AR218711A1 (xx)
BE (1)	BE874795A (xx)
CH (1)	CH637827A5 (xx)
CS (1)	CS207784B2 (xx)
ES (1)	ES478539A0 (xx)
FR (1)	FR2419729B1 (xx)
GB (1)	GB2016271B (xx)
HK (1)	HK49283A (xx)
IE (1)	IE48269B1 (xx)
IT (1)	IT1162282B (xx)
MT (1)	MTP843B (xx)
MX (1)	MX5996E (xx)
NL (1)	NL7901917A (xx)
PH (1)	PH16903A (xx)
PT (1)	PT69341A (xx)
ZA (1)	ZA791103B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3320583A1 (de) *	1983-06-08	1984-12-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
ES2055894T3 (es) *	1989-04-07	1994-09-01	Ciba Geigy Ag	Concentrados de sustancias activas pesticidas y su preparacion.
WO2025115989A1 (ja) *	2023-12-01	2025-06-05	Ｅａファーマ株式会社	医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3432593A (en) *	1963-09-18	1969-03-11	Key Pharm Inc	Delayed and sustained release type pharmaceutical preparation
JPS5635169B2 (xx) *	1974-02-14	1981-08-15
SE421042B (sv) *	1976-06-29	1981-11-23	Kockums Chem	Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans
JPS53148519A (en) *	1977-05-31	1978-12-25	Sumitomo Chem Co Ltd	Preparation of solid medicine containing gefarnate

1978
- 1978-03-14 JP JP53029746A patent/JPS6026093B2/ja not_active Expired
- 1978-08-25 PH PH21668A patent/PH16903A/en unknown
1979
- 1979-03-09 ZA ZA791103A patent/ZA791103B/xx unknown
- 1979-03-09 AR AR275761D patent/AR218711A1/es active
- 1979-03-09 NL NL7901917A patent/NL7901917A/xx not_active Application Discontinuation
- 1979-03-12 ES ES478539A patent/ES478539A0/es active Granted
- 1979-03-13 MT MT843A patent/MTP843B/xx unknown
- 1979-03-13 BE BE0/193985A patent/BE874795A/xx not_active IP Right Cessation
- 1979-03-13 IT IT48332/79A patent/IT1162282B/it active
- 1979-03-13 CS CS791652A patent/CS207784B2/cs unknown
- 1979-03-13 PT PT69341A patent/PT69341A/pt unknown
- 1979-03-13 GB GB7908723A patent/GB2016271B/en not_active Expired
- 1979-03-13 FR FR7906384A patent/FR2419729B1/fr not_active Expired
- 1979-03-13 MX MX797810U patent/MX5996E/es unknown
- 1979-03-14 CH CH243379A patent/CH637827A5/fr not_active IP Right Cessation
- 1979-08-08 IE IE725/79A patent/IE48269B1/en not_active IP Right Cessation
1983
- 1983-11-03 HK HK492/83A patent/HK49283A/xx unknown

Also Published As

Publication number	Publication date
CH637827A5 (fr)	1983-08-31
ZA791103B (en)	1980-03-26
MX5996E (es)	1984-09-18
IT1162282B (it)	1987-03-25
ES8200632A1 (es)	1981-11-01
IE790725L (en)	1979-09-14
MTP843B (en)	1980-02-11
PT69341A (fr)	1979-04-01
IE48269B1 (en)	1984-11-28
JPS54122718A (en)	1979-09-22
HK49283A (en)	1983-11-11
BE874795A (fr)	1979-07-02
NL7901917A (nl)	1979-09-18
FR2419729A1 (fr)	1979-10-12
IT7948332A0 (it)	1979-03-13
PH16903A (en)	1984-04-10
JPS6026093B2 (ja)	1985-06-21
GB2016271B (en)	1982-09-02
GB2016271A (en)	1979-09-26
ES478539A0 (es)	1981-11-01
AR218711A1 (es)	1980-06-30
FR2419729B1 (fr)	1988-07-08

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