CS212269B2 - Method of preparation of the biocompatible fibres from the polymeres - Google Patents

Method of preparation of the biocompatible fibres from the polymeres Download PDF

Info

Publication number: CS212269B2
Authority: CS; Czechoslovakia
Prior art keywords: substances; polymer; biocompatible; added; polymer solution
Prior art date: 1977-03-22

Application number

CS781720A

Other languages

Czech (cs)

English (en)

Inventor

Walter Marconi

Bartoli

Franco Morisi

Francesco Pittali

Original Assignee

Snam Progetti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-22

Filing date

1978-03-17

Publication date

1982-03-26

1978-03-17 Application filed by Snam Progetti filed Critical Snam Progetti

1982-03-26 Publication of CS212269B2 publication Critical patent/CS212269B2/cs

Links

229920000642 polymer Polymers 0.000 title claims abstract description 37
238000000034 method Methods 0.000 title claims description 22
238000002360 preparation method Methods 0.000 title claims description 7
239000000126 substance Substances 0.000 claims abstract description 27
239000003146 anticoagulant agent Substances 0.000 claims abstract description 9
229940127219 anticoagulant drug Drugs 0.000 claims abstract description 8
239000000835 fiber Substances 0.000 claims description 16
238000009987 spinning Methods 0.000 claims description 10
230000008569 process Effects 0.000 claims description 9
239000003795 chemical substances by application Substances 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 5
239000004814 polyurethane Substances 0.000 claims description 5
229920002635 polyurethane Polymers 0.000 claims description 5
108090000790 Enzymes Proteins 0.000 claims description 4
102000004190 Enzymes Human genes 0.000 claims description 4
239000000427 antigen Substances 0.000 claims description 4
102000036639 antigens Human genes 0.000 claims description 4
108091007433 antigens Proteins 0.000 claims description 4
230000001407 anti-thrombic effect Effects 0.000 claims description 3
239000011541 reaction mixture Substances 0.000 claims description 3
238000001179 sorption measurement Methods 0.000 claims description 3
239000002344 surface layer Substances 0.000 claims description 3
NPFBJJBIDYIAJD-UHFFFAOYSA-N 2-(2-amino-1,3-oxazol-4-yl)ethanol Chemical compound NC1=NC(CCO)=CO1 NPFBJJBIDYIAJD-UHFFFAOYSA-N 0.000 claims description 2
238000004873 anchoring Methods 0.000 claims description 2
239000003705 antithrombocytic agent Substances 0.000 claims description 2
229920000249 biocompatible polymer Polymers 0.000 claims description 2
DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 claims description 2
229960001912 dicoumarol Drugs 0.000 claims description 2
229920001577 copolymer Polymers 0.000 abstract description 4
230000009471 action Effects 0.000 abstract description 2
230000000702 anti-platelet effect Effects 0.000 abstract 1
229920000891 common polymer Polymers 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
239000000243 solution Substances 0.000 description 23
210000001772 blood platelet Anatomy 0.000 description 20
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000008280 blood Substances 0.000 description 12
210000004369 blood Anatomy 0.000 description 11
239000000839 emulsion Substances 0.000 description 8
239000000463 material Substances 0.000 description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
229920002284 Cellulose triacetate Polymers 0.000 description 6
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 6
230000000694 effects Effects 0.000 description 6
210000003191 femoral vein Anatomy 0.000 description 6
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
238000004220 aggregation Methods 0.000 description 5
230000002776 aggregation Effects 0.000 description 5
239000011521 glass Substances 0.000 description 5
239000012071 phase Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
208000027418 Wounds and injury Diseases 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
230000017531 blood circulation Effects 0.000 description 3
238000000576 coating method Methods 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
210000003462 vein Anatomy 0.000 description 3
-1 2-hydroxyethylaminooxazol Chemical compound 0.000 description 2
YBRVSVVVWCFQMG-UHFFFAOYSA-N 4,4'-diaminodiphenylmethane Chemical compound C1=CC(N)=CC=C1CC1=CC=C(N)C=C1 YBRVSVVVWCFQMG-UHFFFAOYSA-N 0.000 description 2
241000238876 Acari Species 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
108010049003 Fibrinogen Proteins 0.000 description 2
102000008946 Fibrinogen Human genes 0.000 description 2
102000001554 Hemoglobins Human genes 0.000 description 2
108010054147 Hemoglobins Proteins 0.000 description 2
RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
239000004744 fabric Substances 0.000 description 2
229940012952 fibrinogen Drugs 0.000 description 2
238000001914 filtration Methods 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
238000011886 postmortem examination Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 2
231100000216 vascular lesion Toxicity 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical compound NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 description 1
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
208000032984 Intraoperative Complications Diseases 0.000 description 1
241000186781 Listeria Species 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical class ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
208000027276 Von Willebrand disease Diseases 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
238000004820 blood count Methods 0.000 description 1
235000019994 cava Nutrition 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
239000011247 coating layer Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000004205 dimethyl polysiloxane Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
239000002657 fibrous material Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000002695 general anesthesia Methods 0.000 description 1
ZGEYCCHDTIDZAE-UHFFFAOYSA-N glutamic acid 5-methyl ester Chemical compound COC(=O)CCC(N)C(O)=O ZGEYCCHDTIDZAE-UHFFFAOYSA-N 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000001573 invertase Substances 0.000 description 1
235000011073 invertase Nutrition 0.000 description 1
239000010410 layer Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940043200 pentothal Drugs 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
235000021110 pickles Nutrition 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229940081330 tena Drugs 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/062—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Materials Engineering (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Dispersion Chemistry (AREA)
Microbiology (AREA)
Textile Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Manufacturing & Machinery (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CS781720A 1977-03-22 1978-03-17 Method of preparation of the biocompatible fibres from the polymeres CS212269B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21482/77A IT1085524B (it)	1977-03-22	1977-03-22	Materiali e fibre porose biocompatibili in grado di inglobare sostanze di interesse biologico e metodi per il loro ottenimento

Publications (1)

Publication Number	Publication Date
CS212269B2 true CS212269B2 (en)	1982-03-26

Family

ID=11182479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS781720A CS212269B2 (en)	1977-03-22	1978-03-17	Method of preparation of the biocompatible fibres from the polymeres

Country Status (21)

Country	Link
US (1)	US4353996A (fr)
JP (1)	JPS53117281A (fr)
AU (1)	AU516197B2 (fr)
BE (1)	BE865192A (fr)
CA (1)	CA1095409A (fr)
CH (1)	CH633712A5 (fr)
CS (1)	CS212269B2 (fr)
DD (1)	DD138601A5 (fr)
DE (1)	DE2812174C2 (fr)
DK (1)	DK113478A (fr)
FR (1)	FR2395029A1 (fr)
GB (1)	GB1602163A (fr)
HU (1)	HU179581B (fr)
IL (1)	IL54215A (fr)
IT (1)	IT1085524B (fr)
LU (1)	LU79273A1 (fr)
NL (1)	NL7803101A (fr)
NO (1)	NO144008C (fr)
SE (1)	SE436242B (fr)
YU (1)	YU66678A (fr)
ZA (1)	ZA781362B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1095574B (it) *	1978-04-12	1985-08-10	Snam Progetti	Procedimento per la preparazione di materiali biocompatibili di natura poliammidica e manufatti cosi'ottenuti
IT1096208B (it) *	1978-05-12	1985-08-26	Snam Progetti	Composizione adatta alla riduzione del tenore di fenilalanina e metodo impiegante la stessa
IT1099996B (it) *	1978-10-17	1985-09-28	Anic Spa	Derivati del 4,5-difenil-ossazolo 2-ammino o 2-tio sostituiti e procedimento per il loro ottenimento
DE2920500A1 (de) *	1979-05-21	1980-11-27	Boehringer Sohn Ingelheim	Pharmazeutische zubereitung in form eines polyacrylatfilmes
JPS6076562A (ja) *	1983-10-03	1985-05-01	Sumitomo Electric Ind Ltd	抗血栓性樹脂組成物
FR2554349A1 (fr) *	1983-11-08	1985-05-10	Immunotech Sa	Procede d'obtention de materiaux biocompatibles, materiaux obtenus par ce procede et leurs applications
US4563485A (en) *	1984-04-30	1986-01-07	The Trustees Of Columbia University In The City Of New York	Injection-resistant materials and method of making same through use of nalidixic acid derivatives
US4581028A (en) *	1984-04-30	1986-04-08	The Trustees Of Columbia University In The City Of New York	Infection-resistant materials and method of making same through use of sulfonamides
GB2167665A (en) *	1984-12-04	1986-06-04	Univ Liverpool	Platelet aggregation inhibitor for use in polymeric surgical devices
US4612337A (en) *	1985-05-30	1986-09-16	The Trustees Of Columbia University In The City Of New York	Method for preparing infection-resistant materials
EP0214392B1 (fr) *	1985-07-02	1990-05-23	Omni Medical Limited	Dispositif médical, notamment filtre, canule, cathéter ou implant
US4909799A (en) *	1987-09-18	1990-03-20	Olav Thulesius	Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics
WO1991017724A1 (fr) *	1990-05-17	1991-11-28	Harbor Medical Devices, Inc.	Polymere utilise dans un dispositif medical
US5302393A (en) *	1991-07-11	1994-04-12	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Method for inhibiting biological degradation of implantation polymeric material, inhibitor thereof and implantation polymeric material containing the inhibitor
EP0559911B1 (fr) *	1991-10-01	1997-11-26	Otsuka Pharmaceutical Factory, Inc.	Resine, tube, film et revetement antithrombotiques
EP0568451B1 (fr) *	1992-04-28	1999-08-04	Terumo Kabushiki Kaisha	Composition de polymère thermoplastique et dispositifs médicaux fabriqués à partir de ceux-ci
DE4221665C1 (fr) *	1992-07-02	1993-08-12	Rehau Ag + Co, 8673 Rehau, De
FR2747591B1 (fr) *	1996-04-19	1998-05-22	Hospal Ind	Appareil medical pour le traitement extracorporel du sang ou du plasma et procedes de fabrication de cet appareil
US6221997B1 (en)	1997-04-28	2001-04-24	Kimberly Ann Woodhouse	Biodegradable polyurethanes
GB0113697D0 (en) *	2001-06-06	2001-07-25	Smith & Nephew	Fixation devices for tissue repair
US7056286B2 (en)	2003-11-12	2006-06-06	Adrian Ravenscroft	Medical device anchor and delivery system
AU2009257230B2 (en) *	2008-06-13	2015-05-28	Smith & Nephew, Inc.	Fixation devices for tissue repair
WO2011056981A2 (fr)	2009-11-04	2011-05-12	Nitinol Devices And Components, Inc.	Conception de stent de pontage périphérique alternatif et procédé pour son utilisation
WO2012047308A1 (fr)	2010-10-08	2012-04-12	Nitinol Devices And Components, Inc.	Autre conception d'endoprothèse vasculaire de pont circonférentielle et ses procédés d'utilisation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT241016B (de) *	1962-12-14	1965-06-25	Spofa Vereinigte Pharma Werke	Hochporöse Kollagen-Gewebe-Blutgefäßprothese und Verfahren zur Herstellung derselben
US3674901A (en) *	1966-07-26	1972-07-04	Nat Patent Dev Corp	Surgical sutures
IL32406A (en) *	1968-06-26	1973-01-30	Snam Progetti	Enzyme preparations comprising a solution or dispersion of enzyme occluded in filaments of cellulose esters or synthetic polymers
DE1933270A1 (de) *	1968-07-24	1970-01-29	Ceskoslovenska Akademie Ved	Chirurgischer Naehfaden und Verfahren zu dessen Herstellung
US3846353A (en) *	1970-06-08	1974-11-05	Department Of Health Education	Nonthrombogenic plastic material and method for making the same
US3688317A (en) *	1970-08-25	1972-09-05	Sutures Inc	Vascular prosthetic
US3932656A (en) *	1970-09-10	1976-01-13	Alza Corporation	Article of manufacture for instant release of anti-aggregation and non-thrombogenic agents to biological media
IT1008202B (it) *	1974-07-31	1976-11-10	Lostia Onofrio	Fibre inglobanti anticorpi antige ni antisieri procedimento per la loro preparazione e loro impieghi
IT1052544B (it) *	1974-12-11	1981-07-20	Ethicon Inc	Perfezionamento nei materiali per suture chirurgiche
IT1038741B (it) *	1975-06-06	1979-11-30	Snam Progetti	Processo per l inglobamento di agenti sequestranti in strutture filamentose agenti seqesttanti inglobati cose ottenuti e loro applicazioni
GB1515963A (en) *	1975-07-15	1978-06-28	Massachusetts Inst Technology	Crosslinked collagen-mucopolysaccharide composite materials
GB1556710A (en) *	1975-09-12	1979-11-28	Anic Spa	Method of occluding substances in structures and products obtained thereby
US4073723A (en) *	1976-11-15	1978-02-14	Swank Roy L	Anti-coagulating and filtering blood

1977
- 1977-03-22 IT IT21482/77A patent/IT1085524B/it active
1978
- 1978-03-03 CA CA298,298A patent/CA1095409A/fr not_active Expired
- 1978-03-06 AU AU33850/78A patent/AU516197B2/en not_active Expired
- 1978-03-07 IL IL54215A patent/IL54215A/xx unknown
- 1978-03-08 ZA ZA00781362A patent/ZA781362B/xx unknown
- 1978-03-14 CH CH277778A patent/CH633712A5/it not_active IP Right Cessation
- 1978-03-14 DK DK113478A patent/DK113478A/da not_active Application Discontinuation
- 1978-03-15 GB GB10344/78A patent/GB1602163A/en not_active Expired
- 1978-03-15 NO NO780915A patent/NO144008C/no unknown
- 1978-03-17 CS CS781720A patent/CS212269B2/cs unknown
- 1978-03-20 LU LU79273A patent/LU79273A1/fr unknown
- 1978-03-20 YU YU00666/78A patent/YU66678A/xx unknown
- 1978-03-20 DD DD78204305A patent/DD138601A5/xx unknown
- 1978-03-20 DE DE2812174A patent/DE2812174C2/de not_active Expired
- 1978-03-21 HU HU78SA3101A patent/HU179581B/hu unknown
- 1978-03-21 FR FR7808209A patent/FR2395029A1/fr active Granted
- 1978-03-21 SE SE7803254A patent/SE436242B/sv unknown
- 1978-03-22 JP JP3181278A patent/JPS53117281A/ja active Pending
- 1978-03-22 BE BE186183A patent/BE865192A/fr not_active IP Right Cessation
- 1978-03-22 NL NL7803101A patent/NL7803101A/xx not_active Application Discontinuation
1980
- 1980-09-23 US US06/189,817 patent/US4353996A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DD138601A5 (de)	1979-11-14
HU179581B (en)	1982-11-29
NL7803101A (nl)	1978-09-26
LU79273A1 (fr)	1978-06-29
JPS53117281A (en)	1978-10-13
AU516197B2 (en)	1981-05-21
DE2812174C2 (de)	1981-10-15
IT1085524B (it)	1985-05-28
AU3385078A (en)	1979-09-13
IL54215A (en)	1982-02-28
FR2395029A1 (fr)	1979-01-19
FR2395029B1 (fr)	1982-05-07
SE7803254L (sv)	1978-10-13
GB1602163A (en)	1981-11-11
CA1095409A (fr)	1981-02-10
DK113478A (da)	1978-09-23
NO780915L (no)	1978-09-25
NO144008B (no)	1981-02-23
YU66678A (en)	1984-02-29
DE2812174A1 (de)	1978-09-28
CH633712A5 (it)	1982-12-31
SE436242B (sv)	1984-11-26
NO144008C (no)	1981-06-03
US4353996A (en)	1982-10-12
ZA781362B (en)	1979-02-28
BE865192A (fr)	1978-09-22

Publication	Publication Date	Title
CS212269B2 (en)	1982-03-26	Method of preparation of the biocompatible fibres from the polymeres
AU672708B2 (en)	1996-10-10	Surface modified biocompatible membranes
US5151192A (en)	1992-09-29	Method for removing heparin from blood or plasma
DE69932273T2 (de)	2007-07-12	Befestigung von Biomolekülen an Oberflächen von medizinischen Geräten
US6756125B2 (en)	2004-06-29	Biocompatible medical articles and process for their production
US5342621A (en)	1994-08-30	Antithrombogenic surface
DE68923423T2 (de)	1996-01-25	Antithromotisches medizinisches Material, künstliches inneres Organ und Verfahren zur Herstellung eines antithrombotischen medizinischen Materials.
JPH06507558A (ja)	1994-09-01	ポリマーコーティング
EP0947205A2 (fr)	1999-10-06	Procédé de fabrication d'articles médicaux biocompatibles
DE10004884A1 (de)	2000-08-24	Verfahren zum Anbringen von Biomolekülen an Oberflächen mittels funktioneller Amin-Gruppen
US4289756A (en)	1981-09-15	Physiological preparation containing loaded cells of expanded volume in suspension, for preferential accumulation in spleen and liver
DE19715504C2 (de)	2000-10-26	PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen
WO2016184872A1 (fr)	2016-11-24	Membranes fonctionnalisées par l'héparine pour organes bio-artificiels
US6010475A (en)	2000-01-04	Apparatus for the treatment of blood by extracorporeal circulation and process of manufacture
US4243776A (en)	1981-01-06	Preparation of non-thrombogenic polymeric material article with platelet anti-aggregative agent
DE69127450T2 (de)	1998-01-02	Nichtthrombogene oberflächen
EP0580871B1 (fr)	1998-06-10	Derive de cellulose hydrosoluble et materiau biocompatible
CN101966350A (zh)	2011-02-09	对医用高分子材料抗凝血处理的方法
JP2003515110A (ja)	2003-04-22	血液適合性ポリマー表面
Ito et al.	1986	In vivo and in vitro blood compatibility of polyelectrolyte complexes formed between cellulose derivatives
VON SECESSER et al.	1993	Can protamine be used during perfusion with heparin surface coated equipment?
JPH0144083B2 (fr)	1989-09-26
JPH0343424A (ja)	1991-02-25	血液適合性医療用材料
CN109528788A (zh)	2019-03-29	一种经皮给药治疗缺血性心脑血管疾病的负载川芎油纳米载体及其制备方法
Ma et al.	1993	Applications of Affinity Binding to the Development of Heparin Removing and Sensing Devices