SE436242B - Biokompatibelt polymermaterial samt forfarande for dess framstellning - Google Patents

Biokompatibelt polymermaterial samt forfarande for dess framstellning

Info

Publication number: SE436242B
Authority: SE; Sweden
Prior art keywords: blood; polymeric material; solution; diphenyl; hydroxyethyl
Prior art date: 1977-03-22

Application number

SE7803254A

Other languages

English (en)

Swedish (sv)

Other versions

SE7803254L (sv

Inventor

W Marconi

F Bartoli

F Morisi

F Pittalis

Original Assignee

Anic Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-22

Filing date

1978-03-21

Publication date

1984-11-26

1978-03-21 Application filed by Anic Spa filed Critical Anic Spa

1978-10-13 Publication of SE7803254L publication Critical patent/SE7803254L/xx

1984-11-26 Publication of SE436242B publication Critical patent/SE436242B/sv

Links

238000000034 method Methods 0.000 title claims description 16
238000002360 preparation method Methods 0.000 title claims description 4
239000002861 polymer material Substances 0.000 title 1
229920000642 polymer Polymers 0.000 claims description 21
239000000463 material Substances 0.000 claims description 10
108090000790 Enzymes Proteins 0.000 claims description 4
102000004190 Enzymes Human genes 0.000 claims description 4
239000000427 antigen Substances 0.000 claims description 4
102000036639 antigens Human genes 0.000 claims description 4
108091007433 antigens Proteins 0.000 claims description 4
239000003463 adsorbent Substances 0.000 claims description 3
230000000536 complexating effect Effects 0.000 claims description 3
DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 claims description 3
229960001912 dicoumarol Drugs 0.000 claims description 3
HIZKPJUTKKJDGA-UHFFFAOYSA-N dicumarol Natural products O=C1OC2=CC=CC=C2C(=O)C1CC1C(=O)C2=CC=CC=C2OC1=O HIZKPJUTKKJDGA-UHFFFAOYSA-N 0.000 claims description 3
230000015271 coagulation Effects 0.000 claims description 2
238000005345 coagulation Methods 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical compound NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 claims 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
230000023555 blood coagulation Effects 0.000 claims 1
230000008020 evaporation Effects 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
238000002166 wet spinning Methods 0.000 claims 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
210000001772 blood platelet Anatomy 0.000 description 18
239000000243 solution Substances 0.000 description 18
239000008280 blood Substances 0.000 description 14
210000004369 blood Anatomy 0.000 description 13
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
239000000835 fiber Substances 0.000 description 9
229920002284 Cellulose triacetate Polymers 0.000 description 8
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 8
239000011324 bead Substances 0.000 description 6
239000000839 emulsion Substances 0.000 description 6
239000011521 glass Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
210000003111 iliac vein Anatomy 0.000 description 4
239000012071 phase Substances 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
210000003191 femoral vein Anatomy 0.000 description 3
229920002635 polyurethane Polymers 0.000 description 3
239000004814 polyurethane Substances 0.000 description 3
238000009987 spinning Methods 0.000 description 3
YBRVSVVVWCFQMG-UHFFFAOYSA-N 4,4'-diaminodiphenylmethane Chemical compound C1=CC(N)=CC=C1CC1=CC=C(N)C=C1 YBRVSVVVWCFQMG-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
101100298295 Drosophila melanogaster flfl gene Proteins 0.000 description 2
RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
208000027276 Von Willebrand disease Diseases 0.000 description 2
230000002744 anti-aggregatory effect Effects 0.000 description 2
239000003146 anticoagulant agent Substances 0.000 description 2
229940127219 anticoagulant drug Drugs 0.000 description 2
108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 description 2
229940058180 edetate dipotassium anhydrous Drugs 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
239000001573 invertase Substances 0.000 description 2
235000011073 invertase Nutrition 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
238000011886 postmortem examination Methods 0.000 description 2
208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000003966 vascular damage Effects 0.000 description 2
208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
NPFBJJBIDYIAJD-UHFFFAOYSA-N 2-(2-amino-1,3-oxazol-4-yl)ethanol Chemical compound NC1=NC(CCO)=CO1 NPFBJJBIDYIAJD-UHFFFAOYSA-N 0.000 description 1
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
208000002847 Surgical Wound Diseases 0.000 description 1
IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 1
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical class ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
210000001715 carotid artery Anatomy 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
239000004205 dimethyl polysiloxane Substances 0.000 description 1
JROGBPMEKVAPEH-GXGBFOEMSA-N emetine dihydrochloride Chemical compound Cl.Cl.N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC JROGBPMEKVAPEH-GXGBFOEMSA-N 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
238000002695 general anesthesia Methods 0.000 description 1
ZGEYCCHDTIDZAE-UHFFFAOYSA-N glutamic acid 5-methyl ester Chemical compound COC(=O)CCC(N)C(O)=O ZGEYCCHDTIDZAE-UHFFFAOYSA-N 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
238000007654 immersion Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000010410 layer Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229940043200 pentothal Drugs 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
-1 polydimethylsiloxane Polymers 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
229920001567 vinyl ester resin Polymers 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/062—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Dispersion Chemistry (AREA)
Biotechnology (AREA)
Manufacturing & Machinery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Textile Engineering (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7803254A 1977-03-22 1978-03-21 Biokompatibelt polymermaterial samt forfarande for dess framstellning SE436242B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21482/77A IT1085524B (it)	1977-03-22	1977-03-22	Materiali e fibre porose biocompatibili in grado di inglobare sostanze di interesse biologico e metodi per il loro ottenimento

Publications (2)

Publication Number	Publication Date
SE7803254L SE7803254L (sv)	1978-10-13
SE436242B true SE436242B (sv)	1984-11-26

Family

ID=11182479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7803254A SE436242B (sv)	1977-03-22	1978-03-21	Biokompatibelt polymermaterial samt forfarande for dess framstellning

Country Status (21)

Country	Link
US (1)	US4353996A (fr)
JP (1)	JPS53117281A (fr)
AU (1)	AU516197B2 (fr)
BE (1)	BE865192A (fr)
CA (1)	CA1095409A (fr)
CH (1)	CH633712A5 (fr)
CS (1)	CS212269B2 (fr)
DD (1)	DD138601A5 (fr)
DE (1)	DE2812174C2 (fr)
DK (1)	DK113478A (fr)
FR (1)	FR2395029A1 (fr)
GB (1)	GB1602163A (fr)
HU (1)	HU179581B (fr)
IL (1)	IL54215A (fr)
IT (1)	IT1085524B (fr)
LU (1)	LU79273A1 (fr)
NL (1)	NL7803101A (fr)
NO (1)	NO144008C (fr)
SE (1)	SE436242B (fr)
YU (1)	YU66678A (fr)
ZA (1)	ZA781362B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1095574B (it) *	1978-04-12	1985-08-10	Snam Progetti	Procedimento per la preparazione di materiali biocompatibili di natura poliammidica e manufatti cosi'ottenuti
IT1096208B (it) *	1978-05-12	1985-08-26	Snam Progetti	Composizione adatta alla riduzione del tenore di fenilalanina e metodo impiegante la stessa
IT1099996B (it) *	1978-10-17	1985-09-28	Anic Spa	Derivati del 4,5-difenil-ossazolo 2-ammino o 2-tio sostituiti e procedimento per il loro ottenimento
DE2920500A1 (de) *	1979-05-21	1980-11-27	Boehringer Sohn Ingelheim	Pharmazeutische zubereitung in form eines polyacrylatfilmes
JPS6076562A (ja) *	1983-10-03	1985-05-01	Sumitomo Electric Ind Ltd	抗血栓性樹脂組成物
FR2554349A1 (fr) *	1983-11-08	1985-05-10	Immunotech Sa	Procede d'obtention de materiaux biocompatibles, materiaux obtenus par ce procede et leurs applications
US4563485A (en) *	1984-04-30	1986-01-07	The Trustees Of Columbia University In The City Of New York	Injection-resistant materials and method of making same through use of nalidixic acid derivatives
US4581028A (en) *	1984-04-30	1986-04-08	The Trustees Of Columbia University In The City Of New York	Infection-resistant materials and method of making same through use of sulfonamides
GB2167665A (en) *	1984-12-04	1986-06-04	Univ Liverpool	Platelet aggregation inhibitor for use in polymeric surgical devices
US4612337A (en) *	1985-05-30	1986-09-16	The Trustees Of Columbia University In The City Of New York	Method for preparing infection-resistant materials
EP0214392B1 (fr) *	1985-07-02	1990-05-23	Omni Medical Limited	Dispositif médical, notamment filtre, canule, cathéter ou implant
US4909799A (en) *	1987-09-18	1990-03-20	Olav Thulesius	Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics
AU7998091A (en) *	1990-05-17	1991-12-10	Harbor Medical Devices, Inc.	Medical device polymer
US5302393A (en) *	1991-07-11	1994-04-12	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Method for inhibiting biological degradation of implantation polymeric material, inhibitor thereof and implantation polymeric material containing the inhibitor
DE4293170T1 (de) *	1991-10-01	1993-11-18	Otsuka Pharma Co Ltd	Antithromboseharz, Antithromboseröhrchen, Antithrombosefilm und Antithromboseüberzug
EP0568451B1 (fr) *	1992-04-28	1999-08-04	Terumo Kabushiki Kaisha	Composition de polymère thermoplastique et dispositifs médicaux fabriqués à partir de ceux-ci
DE4221665C1 (fr) *	1992-07-02	1993-08-12	Rehau Ag + Co, 8673 Rehau, De
FR2747591B1 (fr) *	1996-04-19	1998-05-22	Hospal Ind	Appareil medical pour le traitement extracorporel du sang ou du plasma et procedes de fabrication de cet appareil
US6221997B1 (en)	1997-04-28	2001-04-24	Kimberly Ann Woodhouse	Biodegradable polyurethanes
GB0113697D0 (en) *	2001-06-06	2001-07-25	Smith & Nephew	Fixation devices for tissue repair
US7056286B2 (en)	2003-11-12	2006-06-06	Adrian Ravenscroft	Medical device anchor and delivery system
WO2009152487A2 (fr) *	2008-06-13	2009-12-17	Smith & Nephew, Inc.	Dispositifs de fixation pour une réparation de tissu
US9649211B2 (en)	2009-11-04	2017-05-16	Confluent Medical Technologies, Inc.	Alternating circumferential bridge stent design and methods for use thereof
WO2011056981A2 (fr)	2009-11-04	2011-05-12	Nitinol Devices And Components, Inc.	Conception de stent de pontage périphérique alternatif et procédé pour son utilisation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT241016B (de) *	1962-12-14	1965-06-25	Spofa Vereinigte Pharma Werke	Hochporöse Kollagen-Gewebe-Blutgefäßprothese und Verfahren zur Herstellung derselben
US3674901A (en) *	1966-07-26	1972-07-04	Nat Patent Dev Corp	Surgical sutures
IL32406A (en) *	1968-06-26	1973-01-30	Snam Progetti	Enzyme preparations comprising a solution or dispersion of enzyme occluded in filaments of cellulose esters or synthetic polymers
DE1933270A1 (de) *	1968-07-24	1970-01-29	Ceskoslovenska Akademie Ved	Chirurgischer Naehfaden und Verfahren zu dessen Herstellung
US3846353A (en) *	1970-06-08	1974-11-05	Department Of Health Education	Nonthrombogenic plastic material and method for making the same
US3688317A (en) *	1970-08-25	1972-09-05	Sutures Inc	Vascular prosthetic
US3932656A (en) *	1970-09-10	1976-01-13	Alza Corporation	Article of manufacture for instant release of anti-aggregation and non-thrombogenic agents to biological media
IT1008202B (it) *	1974-07-31	1976-11-10	Lostia Onofrio	Fibre inglobanti anticorpi antige ni antisieri procedimento per la loro preparazione e loro impieghi
JPS5270587A (en) *	1974-12-11	1977-06-11	Ethicon Inc	Surgical instrument
IT1038741B (it) *	1975-06-06	1979-11-30	Snam Progetti	Processo per l inglobamento di agenti sequestranti in strutture filamentose agenti seqesttanti inglobati cose ottenuti e loro applicazioni
GB1515963A (en) *	1975-07-15	1978-06-28	Massachusetts Inst Technology	Crosslinked collagen-mucopolysaccharide composite materials
GB1556710A (en) *	1975-09-12	1979-11-28	Anic Spa	Method of occluding substances in structures and products obtained thereby
US4073723A (en) *	1976-11-15	1978-02-14	Swank Roy L	Anti-coagulating and filtering blood

1977
- 1977-03-22 IT IT21482/77A patent/IT1085524B/it active
1978
- 1978-03-03 CA CA298,298A patent/CA1095409A/fr not_active Expired
- 1978-03-06 AU AU33850/78A patent/AU516197B2/en not_active Expired
- 1978-03-07 IL IL54215A patent/IL54215A/xx unknown
- 1978-03-08 ZA ZA00781362A patent/ZA781362B/xx unknown
- 1978-03-14 DK DK113478A patent/DK113478A/da not_active Application Discontinuation
- 1978-03-14 CH CH277778A patent/CH633712A5/it not_active IP Right Cessation
- 1978-03-15 NO NO780915A patent/NO144008C/no unknown
- 1978-03-15 GB GB10344/78A patent/GB1602163A/en not_active Expired
- 1978-03-17 CS CS781720A patent/CS212269B2/cs unknown
- 1978-03-20 LU LU79273A patent/LU79273A1/fr unknown
- 1978-03-20 DD DD78204305A patent/DD138601A5/xx unknown
- 1978-03-20 YU YU00666/78A patent/YU66678A/xx unknown
- 1978-03-20 DE DE2812174A patent/DE2812174C2/de not_active Expired
- 1978-03-21 SE SE7803254A patent/SE436242B/sv unknown
- 1978-03-21 FR FR7808209A patent/FR2395029A1/fr active Granted
- 1978-03-21 HU HU78SA3101A patent/HU179581B/hu unknown
- 1978-03-22 NL NL7803101A patent/NL7803101A/xx not_active Application Discontinuation
- 1978-03-22 JP JP3181278A patent/JPS53117281A/ja active Pending
- 1978-03-22 BE BE186183A patent/BE865192A/fr not_active IP Right Cessation
1980
- 1980-09-23 US US06/189,817 patent/US4353996A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU516197B2 (en)	1981-05-21
LU79273A1 (fr)	1978-06-29
IL54215A (en)	1982-02-28
FR2395029A1 (fr)	1979-01-19
US4353996A (en)	1982-10-12
IT1085524B (it)	1985-05-28
NO780915L (no)	1978-09-25
DE2812174C2 (de)	1981-10-15
BE865192A (fr)	1978-09-22
FR2395029B1 (fr)	1982-05-07
DD138601A5 (de)	1979-11-14
CH633712A5 (it)	1982-12-31
AU3385078A (en)	1979-09-13
DK113478A (da)	1978-09-23
NL7803101A (nl)	1978-09-26
GB1602163A (en)	1981-11-11
HU179581B (en)	1982-11-29
DE2812174A1 (de)	1978-09-28
SE7803254L (sv)	1978-10-13
NO144008B (no)	1981-02-23
ZA781362B (en)	1979-02-28
CA1095409A (fr)	1981-02-10
JPS53117281A (en)	1978-10-13
YU66678A (en)	1984-02-29
CS212269B2 (en)	1982-03-26
NO144008C (no)	1981-06-03

Publication	Publication Date	Title
CA1095409A (fr)	1981-02-10	Fibres synthetiques biocompatibles et methode de preparation
EP0466178B1 (fr)	1997-06-25	Méthode et appareil pour enlever l'héparine
US4795641A (en)	1989-01-03	Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
FI86070B (fi)	1992-03-31	Metod att bilda en foerbaettrad hydrofil belaeggning pao ett polymert ytskikt samt en medicinsk artikel.
US5496581A (en)	1996-03-05	Polymeric coating
EP0044405B1 (fr)	1986-02-26	Membrane à fibre creuse pour la séparation de plasma et procédé pour sa fabrication
DE3434104C2 (fr)	1991-06-20
EP0267286A1 (fr)	1988-05-18	Filtre pour l'extraction selective de leucocytes
US6010475A (en)	2000-01-04	Apparatus for the treatment of blood by extracorporeal circulation and process of manufacture
Goudie et al.	2017	Characterization and in vivo performance of nitric oxide‐releasing extracorporeal circuits in a feline model of thrombogenicity
Wilner et al.	1978	Thrombogenicity of angiographic catheters.
US4243776A (en)	1981-01-06	Preparation of non-thrombogenic polymeric material article with platelet anti-aggregative agent
US4681713A (en)	1987-07-21	Method of making a hollow fiber membrane for dialysis
DE69127450T2 (de)	1998-01-02	Nichtthrombogene oberflächen
EP0580871B1 (fr)	1998-06-10	Derive de cellulose hydrosoluble et materiau biocompatible
JPS62172961A (ja)	1987-07-29	血液接触医用物品の表面を抗血栓形成にする方法
JP3495802B2 (ja)	2004-02-09	医療用材料およびホスホリルコリン基を有するポリビニルアルコール系重合体
Ito et al.	1986	In vivo and in vitro blood compatibility of polyelectrolyte complexes formed between cellulose derivatives
Johnston et al.	1977	Examination of the filterability of oxygenated erythrocytes (containing normal, trait or sickle cell disease type hemoglobins) in the presence of L-epinephrine, D, L-isoproterenol or prostaglandins (PG) A1, A2, E1, E2, F1α or F2α
GB2183539A (en)	1987-06-10	Hollow fibre membrane for dialysis
JPH0556175B2 (fr)	1993-08-18
Mari et al.	1978	Thrombogenicity of an artificial surface is decreased by the antiplatelet agent ditazol
Yu	1993	Modification of polymeric biomaterials for improved blood compatibility: investigation of protein adsorption and in vitro blood response
DE60019766T2 (de)	2006-01-19	Triflusal oder htb tragende biokompatible polymersysteme
AU624351B2 (en)	1992-06-11	Device and method for separating leucocytes from platelet concentrate