CS260097B1 - 11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát - Google Patents

11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát Download PDF

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CS260097B1
CS260097B1 CS873860A CS386087A CS260097B1 CS 260097 B1 CS260097 B1 CS 260097B1 CS 873860 A CS873860 A CS 873860A CS 386087 A CS386087 A CS 386087A CS 260097 B1 CS260097 B1 CS 260097B1
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CS
Czechoslovakia
Prior art keywords
dihydrodibenzo
maleate
substance
binding sites
antireserpine
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CS873860A
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Czech (cs)
English (en)
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CS386087A1 (en
Inventor
Miroslav Protiva
Karel Sindelar
Martin Valchar
Natasa Dlohozkova
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Miroslav Protiva
Karel Sindelar
Martin Valchar
Natasa Dlohozkova
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Application filed by Miroslav Protiva, Karel Sindelar, Martin Valchar, Natasa Dlohozkova filed Critical Miroslav Protiva
Priority to CS873860A priority Critical patent/CS260097B1/sk
Publication of CS386087A1 publication Critical patent/CS386087A1/cs
Publication of CS260097B1 publication Critical patent/CS260097B1/sk

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Abstract

Řeěení spadá obodu syntetických léčiv. Jeho předmětem je antireserpinově a anticholinergicky účinný 11-(3-dimetylaminopropyl)-6,ll-dihydrodibenzo/b,e/thiepin- -2-karbonitril a jeho maleinát. Ve formě této soli vykazuje jmenovaná látka kromě již uvedené antireserpinově a anticholinergické aktivity vysokou afinitu k vazebným místům /3H/imipraminu v hypothalamu krys při současné nízké afinitě k vazebným místům /3H/desipraminu v téže mozkové struktuře. Naznačuje to možnost inhibice zpětného příjmu 5-hydroxytryptaminu v mozku a praktickou použitelnost látky jako antidepresiva nového typu. Příprava látky podle řešení spočívá v reakci N,N-dimetyl-3-(2-brom- -6,ll-dihydrodibenzo/b,e/thiepin-ll-yl)- propylaminu s kyanidem mědným v hexametylfosfortriamidu při 150 °C a v chromatografické separaci vzniklé směsi. Neutralizací base kyselinou maleinovou se získá krystalický maleinát, který je vhodný k farmakologickým testům i k výrobě lékových forem
CS873860A 1987-05-27 1987-05-27 11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát CS260097B1 (sk)

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Application Number Priority Date Filing Date Title
CS873860A CS260097B1 (sk) 1987-05-27 1987-05-27 11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát

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Application Number Priority Date Filing Date Title
CS873860A CS260097B1 (sk) 1987-05-27 1987-05-27 11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát

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CS386087A1 CS386087A1 (en) 1988-03-15
CS260097B1 true CS260097B1 (sk) 1988-11-15

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CS873860A CS260097B1 (sk) 1987-05-27 1987-05-27 11 -(3-Dimethylaminopropyl)-6-11 -dihydrodibenzo-/b.e/thiepin-2-karbonitril a jeho maleinát

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