CS264222B1 - N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them - Google Patents

N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them Download PDF

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Publication number
CS264222B1
CS264222B1 CS865469A CS546986A CS264222B1 CS 264222 B1 CS264222 B1 CS 264222B1 CS 865469 A CS865469 A CS 865469A CS 546986 A CS546986 A CS 546986A CS 264222 B1 CS264222 B1 CS 264222B1
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CS
Czechoslovakia
Prior art keywords
formula
compounds
derivatives
bases
evaporated
Prior art date
Application number
CS865469A
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Czech (cs)
English (en)
Other versions
CS546986A1 (en
Inventor
Antonin Rndr Drsc Holy
Ivan Ing Rosenberg
Erik Prof Dr Declercq
Original Assignee
Holy Antonin
Rosenberg Ivan
Erik Prof Dr Declercq
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holy Antonin, Rosenberg Ivan, Erik Prof Dr Declercq filed Critical Holy Antonin
Priority to CS865469A priority Critical patent/CS264222B1/cs
Priority to NZ221100A priority patent/NZ221100A/xx
Priority to IE194487A priority patent/IE60117B1/en
Priority to DE1997175085 priority patent/DE19775085I2/de
Priority to AT87110399T priority patent/ATE57932T1/de
Priority to ES198787110399T priority patent/ES2036194T3/es
Priority to IL83235A priority patent/IL83235A/xx
Priority to DK373487A priority patent/DK170646B1/da
Priority to US07/074,900 priority patent/US5142051A/en
Priority to CA000542404A priority patent/CA1340856C/en
Priority to ZA875283A priority patent/ZA875283B/xx
Priority to EP87110399A priority patent/EP0253412B1/de
Priority to FI873165A priority patent/FI86856C/fi
Priority to DE8787110399T priority patent/DE3765864D1/de
Priority to AU75759/87A priority patent/AU600002B2/en
Priority to JP62179877A priority patent/JPH0822866B2/ja
Priority to KR87007844A priority patent/KR950004179B1/ko
Priority to EG42/87A priority patent/EG18273A/xx
Priority to PT85354A priority patent/PT85354B/pt
Publication of CS546986A1 publication Critical patent/CS546986A1/cs
Publication of CS264222B1 publication Critical patent/CS264222B1/cs
Priority to GR90400937T priority patent/GR3002534T3/el
Priority to US08/320,591 priority patent/US5641763A/en
Priority to US08/412,398 priority patent/US5869467A/en
Priority to NL970036C priority patent/NL970036I2/nl
Priority to LU90155C priority patent/LU90155I2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS865469A 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them CS264222B1 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ221100A NZ221100A (en) 1986-07-18 1987-07-16 N-phosphonylmethoxyalkyl pyrimidines and purines and pharmaceutical compositions thereof
EP87110399A EP0253412B1 (de) 1986-07-18 1987-07-17 N-Phosphonylmethoxyalkyl-Derivate von Pyrimidin- und Purinbasen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antiviraler Wirkung, die sie enthalten
DE8787110399T DE3765864D1 (de) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl-derivate von pyrimidin- und purinbasen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen mit antiviraler wirkung, die sie enthalten.
AT87110399T ATE57932T1 (de) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl-derivate von pyrimidin- und purinbasen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen mit antiviraler wirkung, die sie enthalten.
ES198787110399T ES2036194T3 (es) 1986-07-18 1987-07-17 Derivados n-fosfonilmetoxialquilicos de bases de pirimidina y purina, metodos para su preparacion y composiciones farmaceuticas basadas en ellos, con actividad antivirica.
IL83235A IL83235A (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
DK373487A DK170646B1 (da) 1986-07-18 1987-07-17 N-fosfonylmetoxyalkylderivater af pyrimidinbaser og purinbaser, fremgangsmåder til fremstilling heraf, samt lægemiddelpræparat med antiviral virkning indeholdende et sådant derivat
US07/074,900 US5142051A (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity
CA000542404A CA1340856C (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
ZA875283A ZA875283B (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
IE194487A IE60117B1 (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity
FI873165A FI86856C (fi) 1986-07-18 1987-07-17 Foerfarande foer framstaellning av n-fosfonylmetoxialkylpyrimidiner och -puriner
DE1997175085 DE19775085I2 (de) 1986-07-18 1987-07-17 N-Phosphonylmethoxyalkyl-Derivate von Pyrimidin- und Purinbasen, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen mit antiviraler Wirkung, die sie enthalten.
AU75759/87A AU600002B2 (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
JP62179877A JPH0822866B2 (ja) 1986-07-18 1987-07-18 プリンおよびピリミジン塩基のｎ−ホスホニルメトキシアルキル誘導体
KR87007844A KR950004179B1 (en) 1986-07-18 1987-07-18 N-phosphonylmethoxyalkye derivatives of pyrimidine and purine bases and a therapeutical composition therefrom with antiviral activity
EG42/87A EG18273A (en) 1986-07-18 1987-07-19 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof
PT85354A PT85354B (pt) 1986-07-18 1987-07-20 Processo de preparacao de derivados n-fosfonilmetoxialquilo de bases pirimidina e purina e de composicoes farmaceuticas que os contem
GR90400937T GR3002534T3 (en) 1986-07-18 1990-11-19 N-phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity
US08/320,591 US5641763A (en) 1986-07-18 1994-10-11 N-phosphonylmethoxyalkyl derivatives of pyrimdine and purine bases and a therapeutical composition therefrom with antiviral activity
US08/412,398 US5869467A (en) 1986-07-18 1995-03-28 9-(2-phosphonylmethoxyethyl) guanine
NL970036C NL970036I2 (nl) 1986-07-18 1997-10-01 N-fosfonylmethoxyalkylderivaten van pyrimidine en purinebasen, werkwijze voor de bereiding hiervan en farmaceutische samenstellingen hiervan met een antivirale activiteit.
LU90155C LU90155I2 (fr) 1986-07-18 1997-10-21 Vistide - cidofovir 75 mg/ml

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Publications (2)

Publication Number Publication Date
CS546986A1 CS546986A1 (en) 1988-08-16
CS264222B1 true CS264222B1 (en) 1989-06-13

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Country Status (21)

Country Link
US (3) US5142051A (de)
EP (1) EP0253412B1 (de)
JP (1) JPH0822866B2 (de)
KR (1) KR950004179B1 (de)
AT (1) ATE57932T1 (de)
AU (1) AU600002B2 (de)
CA (1) CA1340856C (de)
CS (1) CS264222B1 (de)
DE (2) DE3765864D1 (de)
DK (1) DK170646B1 (de)
EG (1) EG18273A (de)
ES (1) ES2036194T3 (de)
FI (1) FI86856C (de)
GR (1) GR3002534T3 (de)
IE (1) IE60117B1 (de)
IL (1) IL83235A (de)
LU (1) LU90155I2 (de)
NL (1) NL970036I2 (de)
NZ (1) NZ221100A (de)
PT (1) PT85354B (de)
ZA (1) ZA875283B (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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DK373487D0 (da) 1987-07-17
FI86856B (fi) 1992-07-15
LU90155I2 (fr) 1997-12-22
IL83235A (en) 1992-11-15
ATE57932T1 (de) 1990-11-15
EG18273A (en) 1992-12-30
NL970036I2 (nl) 1998-03-02
IE60117B1 (en) 1994-06-01
PT85354B (pt) 1990-04-30
DK170646B1 (da) 1995-11-20
EP0253412A3 (en) 1989-04-26
JPH0822866B2 (ja) 1996-03-06
DE3765864D1 (de) 1990-12-06
KR880001688A (ko) 1988-04-26
CS546986A1 (en) 1988-08-16
IL83235A0 (en) 1987-12-31
PT85354A (en) 1987-08-01
NZ221100A (en) 1991-09-25
IE871944L (en) 1988-01-18
EP0253412A2 (de) 1988-01-20
NL970036I1 (nl) 1997-12-01
US5641763A (en) 1997-06-24
FI86856C (fi) 1992-10-26
FI873165L (fi) 1988-01-19
AU7575987A (en) 1988-01-21
US5869467A (en) 1999-02-09
AU600002B2 (en) 1990-08-02
GR3002534T3 (en) 1993-01-25
DK373487A (da) 1988-01-19
CA1340856C (en) 1999-12-21
FI873165A0 (fi) 1987-07-17
US5142051A (en) 1992-08-25
ZA875283B (en) 1988-03-30
JPS6345289A (ja) 1988-02-26
DE19775085I2 (de) 2004-01-15
KR950004179B1 (en) 1995-04-27
ES2036194T3 (es) 1993-05-16
EP0253412B1 (de) 1990-10-31

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