CS264721B1 - Hydrophilic emulsion cream - Google Patents
Hydrophilic emulsion cream Download PDFInfo
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- CS264721B1 CS264721B1 CS872085A CS208587A CS264721B1 CS 264721 B1 CS264721 B1 CS 264721B1 CS 872085 A CS872085 A CS 872085A CS 208587 A CS208587 A CS 208587A CS 264721 B1 CS264721 B1 CS 264721B1
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- hydrophilic
- emulsion cream
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- aminotridecane
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Abstract
Riešenie sa týká hydrofilného emulzného krému, obsahujúceho v hydrofóbnej i hydrofilnej zložke zlúčeniny 2-aminotridekanu p&sobiace dezinfekčně, antimikrobiálne a antimykoticky, čím je zabezpečený povrchový i hlbkový účinok.The solution relates to a hydrophilic emulsion cream containing 2-aminotridecane compounds in the hydrophobic and hydrophilic components, which have a disinfecting, antimicrobial and antifungal effect, thereby ensuring both a superficial and a deep effect.
Description
264721 2264721 2
Vynález sa týká hydrofilného emulzného krému určeného najmH k mikrobiálněj ochraně po-kožky pracujúcich v polnohospodárstve, tažkom priemysle, chemickom priemysle, zdravotníctvea pod.BACKGROUND OF THE INVENTION The present invention relates to a hydrophilic emulsion cream designed especially for microbial skin protection in agriculture, heavy industry, chemical industry, and health.
Hydrofilné emulzné krémy patria medzi disperzně systémy emulzného typu, kde vodná fázatvoří vonkajšiu kontinuálnu část a hydrofóbňu fázu, ktorá je v nej rovnoměrně dispergovaná.Hydrophilic emulsion creams are emulsion type dispersion systems wherein the aqueous phase forms the outer continuous portion and the hydrophobic phase is uniformly dispersed therein.
Nazývajú sa emulzie olej vo vodě 0/V.They are called oil-in-water emulsions 0 / V.
Dezinfekčně krémy typu 0/V obsahujú vHčšinou účinná látku vo vodnej, to znamená vonkaj-šej fáze, která je v nej rozpustná, t. j. aktívna látka je nepřestupná lipofilnou bariéroukože a je účinná len povrchovo.Type 0 / V disinfectant creams typically contain the active ingredient in an aqueous, i.e., external phase, soluble therein, i.e., the active agent is non-permeable to the lipophilic barrier and is only superficially effective.
Príkladom sú ochranné pracovně emulzné krémy, ktoré obsahujú 2-aminotridekan kyslýadipát. Ďalšími účinnými látkami, ktoré sa používajú v tejto terapeutickéj oblasti sú napr.mucidín (Masák, Antimykotika, studijní správa č. 2 075, 1983, VOFB). Nevýhodou tejto látkyje nízká rozpustnost vo vodě a tým aj obmedzenie terapeutickéj použitelnosti.Examples are protective emulsion creams which contain 2-aminotridecane acid adipate. Other active compounds used in this therapeutic field are, for example, mucidine (Masak, Antimycotics, Study Report No. 2,075, 1983, VOFB). A disadvantage of this substance is its low water solubility and hence the limitation of therapeutic applicability.
Iným liečivom, ktoré sa používá externe je bifonazol (Plempel, M. Antimycotic efficacyof bifonazole in vitro and in vivo., Arzneim. Forsch. 33, 1983, 517-524). Jeho velkou nevý-hodou je nízký účinok proti kvasinkám.Another drug used externally is bifonazole (Plempel, M. Antimycotic efficacyof bifonazole in vitro and in vivo, Arzneim. Forsch. 33, 1983, 517-524). Its great disadvantage is its low anti-yeast effect.
Podobné nízký antibakteriálny účinok sa našiel u imazalilu (Thienpont, D., The biologicaland toxicological properties of imazalil. Arzneim. Forsch., 31, 1981, 309-315).A similar low antibacterial effect was found with imazalil (Thienpont, D., The Biological Biochemical Properties of Imazalil. Arzneim. Forsch., 31, 1981, 309-315).
Hydrofilný emulzný krém podlá předmětného vynálezu rieši tieto nedostatky tým, že v hyd-rofóbnej časti emulzie je rozpuštěný 2-aminotridekan undecylenát, ktorý je schopný penetráciecez lipofilnú bariéru kože a hydrofilná část emulzného krému obsahuje 2-aminotridekan kyslýadipát. Přítomnost účinných látok v obidvoch fázach zaisťuje komplexný dezinfekčný, antimikrobi-álny a antimykotický účinok pracovného ochranného emulzného krému. Výhodou riešenia podlá vynálezu je kombinovaný povrchový i hlbkový dezinfekčný, anti-mikrobiálny a antimykotický účinok zabezpečujúci ochranu narušenej pokožky.The hydrophilic emulsion cream of the present invention solves these drawbacks by dissolving 2-aminotridecane undecylenate in the hydrophobic portion of the emulsion, which is capable of penetrating through the lipophilic skin barrier, and the hydrophilic portion of the emulsion cream contains 2-aminotridecane acid adipate. The presence of the active ingredients in both phases provides a comprehensive disinfectant, antimicrobial and antifungal effect of the protective protective emulsion cream. The advantage of the solution according to the invention is a combined surface and deep disinfectant, anti-microbial and antimycotic effect ensuring protection of the damaged skin.
Podstatou vynálezu je hydrofilný pracovný ochranný krém vyznačujúci sa tým, že v hydro-fóbnej časti obsahuje 2-aminotridekan undecylát v množstve od 0,25 do 0,50 % hmotnostnýchs výhodou 0,25 % hmotnostných a v hydrofilnéj časti emulzie 0,10 % hmotnostných až 0,50 ihmotnostných s výhodou 0,10 % hmotnostných·2-aminotridekan kyslý adipát.SUMMARY OF THE INVENTION The subject of the invention is a hydrophilic protective protective cream, characterized in that in the hydrophobic part, the 2-aminotridecane undecylate contains from 0.25 to 0.50% by weight, preferably 0.25% by weight and 0.10% by weight in the hydrophilic part of the emulsion. up to 0.50 wt%, preferably 0.10 wt%, 2-aminotridecane acid adipate.
Pracovný ochranný hydrofilný emulzný krém podlá vynálezu bol klinicky odskúšaný a vyka-zuje výrazné dezinfekčně, antimikrobiálne a antimykotické účinky.The working protective hydrophilic emulsion cream of the invention has been clinically tested and exhibits significant disinfection, antimicrobial and antifungal effects.
Uvedená kombinácia antimikrobiálnych látok bola odskúŠaná podlá britského liekopisu(B. P. Presservative Effectiveness Test 1980) s použitými kmeňmi: S. aureus ATCC 6 538This combination of antimicrobial agents was tested according to the British Pharmacopoeia (B. P. Presservative Effectiveness Test 1980) with the strains used: S. aureus ATCC 6 538
Ps. aeruginosa NTCC 675 C. albicans ATCC 10 231 A. niger ATCC 16 404. Výsledky ukazujú vo všetkých prípadoch zvolených mikroorganizmov výrazný pokles počtu jednotiek mikroorganizmov vo formulácii.Ps. aeruginosa NTCC 675 C. albicans ATCC 10 231 A. niger ATCC 16 404. The results show a significant decrease in the number of microorganism units in the formulation in all cases of selected microorganisms.
Stabilita hydrofilného krému bola skúšaná štandardným postupom pri obyčajnej teplote, +5 °c, +40 °C a piatich cykloch tuhnutia (topenia, ktoré simulujú kolísanie teploty počas skladovania). řThe stability of the hydrophilic cream was tested by standard procedures at ordinary temperature, + 5 ° C, + 40 ° C, and five solidification cycles (melts that simulate temperature fluctuations during storage). ř
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS872085A CS264721B1 (en) | 1987-03-26 | 1987-03-26 | Hydrophilic emulsion cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS872085A CS264721B1 (en) | 1987-03-26 | 1987-03-26 | Hydrophilic emulsion cream |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS208587A1 CS208587A1 (en) | 1988-11-15 |
| CS264721B1 true CS264721B1 (en) | 1989-09-12 |
Family
ID=5356911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS872085A CS264721B1 (en) | 1987-03-26 | 1987-03-26 | Hydrophilic emulsion cream |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS264721B1 (en) |
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1987
- 1987-03-26 CS CS872085A patent/CS264721B1/en not_active IP Right Cessation
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| Publication number | Publication date |
|---|---|
| CS208587A1 (en) | 1988-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20020326 |