CS541186A3 - Distamycin derivatives and process for preparing thereof - Google Patents

Distamycin derivatives and process for preparing thereof

Info

Publication number: CS541186A3
Authority: CS; Czechoslovakia
Prior art keywords: preparing; distamycin derivatives; distamycin; derivatives
Prior art date: 1985-07-16

Application number

CS865411A

Other languages

English (en)

Inventor

Federico Arcamone

Nicola Mongelli

Fabio Animati

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-16

Filing date

1986-07-16

Publication date

1992-09-16

1986-07-16 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1992-09-16 Publication of CS541186A3 publication Critical patent/CS541186A3/cs

1993-06-16 Publication of CZ277823B6 publication Critical patent/CZ277823B6/cs

Links

238000004519 manufacturing process Methods 0.000 title 1
UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

CS865411A 1985-07-16 1986-07-16 Distamycin derivatives and process for preparing thereof CZ277823B6 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB858517923A GB8517923D0 (en)	1985-07-16	1985-07-16	Distamycin derivatives

Publications (2)

Publication Number	Publication Date
CS541186A3 true CS541186A3 (en)	1992-09-16
CZ277823B6 CZ277823B6 (en)	1993-06-16

Family

ID=10582358

Country Status (29)

Country	Link
US (1)	US4738980A (cs)
JP (1)	JPH0780842B2 (cs)
KR (1)	KR940003495B1 (cs)
CN (2)	CN85103908A (cs)
AT (1)	AT386822B (cs)
AU (1)	AU584723B2 (cs)
BE (1)	BE905109A (cs)
CA (1)	CA1247627A (cs)
CH (1)	CH671958A5 (cs)
CZ (1)	CZ277823B6 (cs)
DE (1)	DE3623853C2 (cs)
DK (1)	DK335886A (cs)
ES (1)	ES2000346A6 (cs)
FI (1)	FI82929C (cs)
FR (1)	FR2585019B1 (cs)
GB (2)	GB8517923D0 (cs)
GR (1)	GR861840B (cs)
HU (1)	HU198087B (cs)
IE (1)	IE59275B1 (cs)
IL (1)	IL79401A (cs)
IT (1)	IT1213103B (cs)
NL (1)	NL8601838A (cs)
NO (1)	NO169014C (cs)
NZ (1)	NZ216828A (cs)
PH (1)	PH23459A (cs)
PT (1)	PT82985B (cs)
SE (1)	SE468594B (cs)
SU (2)	SU1535378A3 (cs)
ZA (1)	ZA865262B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv) *	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
US5310752A (en) *	1986-05-20	1994-05-10	Farmitalia Carlo Erba Spa	Site specific alkylating agents
US5049579A (en) *	1986-05-20	1991-09-17	Farmitalia Carlo Erba, S.R.L.	Site specific alkylating agents
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
WO1992013838A1 (en) *	1991-02-06	1992-08-20	Synphar Laboratories, Inc.	Oligopeptide antiretroviral agents
IT1262921B (it) *	1992-01-10	1996-07-22	Federico Arcamone	Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
DE4205948C2 (de) *	1992-02-24	1996-10-31	Mannesmann Ag	Farbbandkassette für ein endloses Farbband
US5273991A (en) *	1992-07-29	1993-12-28	Research Corporation Technologies, Inc.	Imidazole-containing compositions and methods of use thereof analogs of distamycin
EP0792262A2 (en) *	1994-11-14	1997-09-03	Nzym, Inc.	Methods and compositions for treating phytopathogenic fungi infections
US5637621A (en) *	1994-11-14	1997-06-10	Nzym, Inc.	Methods and compositions for treating Botrytis infections
US5629348A (en) *	1994-11-14	1997-05-13	Nzym, Inc.	Methods and compositions for treating septoria infections
DE19805431A1 (de) *	1998-02-11	1999-08-12	Merck Patent Gmbh	Heteroaromatische Oligoamide als Affinitätsliganden
CA2403537A1 (en) *	2000-03-16	2001-10-11	Genesoft, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) *	2001-03-14	2006-07-18	Genesoft Pharmaceuticals, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
ITTO20010633A1 (it) *	2001-07-02	2003-01-02	Univ Ferrara	Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
ATE425753T1 (de)	2002-08-02	2009-04-15	Genesoft Pharmaceuticals Inc	Biaryl-verbindungen mit antiinfektiver wirkung
EP1562931A2 (en) *	2002-10-25	2005-08-17	Genesoft Pharmaceuticals, Inc.	Anti-infective biaryl compounds
JP2006509027A (ja) *	2002-12-10	2006-03-16	オーシェントファーマシューティカルズコーポレーション	（ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
WO2005051318A2 (en) *	2003-11-24	2005-06-09	Viropharma Incorporated	Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
WO2016159092A1 (ja) *	2015-03-30	2016-10-06	ＭｅｉｊｉＳｅｉｋａファルマ株式会社	エピルビシンの製造方法およびその新規な製造中間体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA557568A (en) *		1958-05-20	J. Weiss Martin	Substituted aminopyrrolecarboxylic acids and esters
CA547128A (en) *		1957-10-08	W. Waller Coy	Substituted pyrrolecarboxamidopyrroles
FR86210E (cs) *	1963-04-04	1966-03-23
DE1795539A1 (de) *	1963-07-26	1972-01-13	Farmaceutici Italia	Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
DE1470284B1 (de) *	1963-07-26	1971-12-16	Farmaceutici Italia	Beta-{1-Methyl-4-[1-methyl-4-(1-methyl-4-formylamino-pyrrol-2-carboxamido)-pyrrol-2-carboxamido]-pyrrol-2-carboxamido}-propionamidin sowie dessen Saeureadditionssalze
FR141F (fr) *	1963-07-26	1965-07-08	Farmaceutici Italia	Nouveaux dérivés du pyrrol
BE666612A (cs) *	1963-07-26	1965-11-03
NL130086C (cs) *	1964-07-14	1970-06-15
SE468642B (sv) *	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents

1985
- 1985-06-08 CN CN198585103908A patent/CN85103908A/zh active Pending
- 1985-07-16 GB GB858517923A patent/GB8517923D0/en active Pending
- 1985-10-03 US US06/783,508 patent/US4738980A/en not_active Expired - Fee Related
1986
- 1986-07-11 SE SE8603099A patent/SE468594B/sv not_active IP Right Cessation
- 1986-07-11 AT AT0188786A patent/AT386822B/de not_active IP Right Cessation
- 1986-07-14 HU HU862903A patent/HU198087B/hu not_active IP Right Cessation
- 1986-07-14 NZ NZ216828A patent/NZ216828A/xx unknown
- 1986-07-14 ES ES8600291A patent/ES2000346A6/es not_active Expired
- 1986-07-14 IL IL79401A patent/IL79401A/xx not_active IP Right Cessation
- 1986-07-14 IE IE187486A patent/IE59275B1/en not_active IP Right Cessation
- 1986-07-14 NL NL8601838A patent/NL8601838A/xx not_active Application Discontinuation
- 1986-07-14 AU AU60203/86A patent/AU584723B2/en not_active Ceased
- 1986-07-15 IT IT8621124A patent/IT1213103B/it active
- 1986-07-15 PH PH34013A patent/PH23459A/en unknown
- 1986-07-15 NO NO862861A patent/NO169014C/no unknown
- 1986-07-15 DE DE3623853A patent/DE3623853C2/de not_active Expired - Fee Related
- 1986-07-15 DK DK335886A patent/DK335886A/da not_active Application Discontinuation
- 1986-07-15 KR KR1019860005716A patent/KR940003495B1/ko not_active Expired - Fee Related
- 1986-07-15 BE BE0/216923A patent/BE905109A/fr not_active IP Right Cessation
- 1986-07-15 SU SU864027842A patent/SU1535378A3/ru active
- 1986-07-15 JP JP61164878A patent/JPH0780842B2/ja not_active Expired - Lifetime
- 1986-07-15 CA CA000513756A patent/CA1247627A/en not_active Expired
- 1986-07-15 CH CH2821/86A patent/CH671958A5/de not_active IP Right Cessation
- 1986-07-15 ZA ZA865262A patent/ZA865262B/xx unknown
- 1986-07-15 FR FR868610295A patent/FR2585019B1/fr not_active Expired
- 1986-07-15 GR GR861840A patent/GR861840B/el unknown
- 1986-07-15 PT PT82985A patent/PT82985B/pt not_active IP Right Cessation
- 1986-07-16 FI FI862960A patent/FI82929C/fi not_active IP Right Cessation
- 1986-07-16 CN CN86104774A patent/CN1026984C/zh not_active Expired - Fee Related
- 1986-07-16 GB GB8617293A patent/GB2178037B/en not_active Expired
- 1986-07-16 CZ CS865411A patent/CZ277823B6/cs unknown
1987
- 1987-11-11 SU SU874203631A patent/SU1538893A3/ru active

Also Published As

Publication number	Publication date
NO862861D0 (no)	1986-07-15
SU1538893A3 (ru)	1990-01-23
CN86104774A (zh)	1987-02-11
DE3623853C2 (de)	1995-12-21
BE905109A (fr)	1987-01-15
DK335886D0 (da)	1986-07-15
GB2178037A (en)	1987-02-04
NO169014C (no)	1992-04-29
FI862960L (fi)	1987-01-17
ATA188786A (de)	1988-03-15
SU1535378A3 (ru)	1990-01-07
IT1213103B (it)	1989-12-07
AU584723B2 (en)	1989-06-01
FI862960A0 (fi)	1986-07-16
CA1247627A (en)	1988-12-28
JPH0780842B2 (ja)	1995-08-30
IL79401A (en)	1991-05-12
PT82985B (pt)	1989-01-30
GB8517923D0 (en)	1985-08-21
CH671958A5 (cs)	1989-10-13
IE861874L (en)	1987-01-16
DK335886A (da)	1987-01-17
PT82985A (pt)	1986-08-01
SE8603099L (sv)	1987-01-17
NL8601838A (nl)	1987-02-16
IT8621124A0 (it)	1986-07-15
AU6020386A (en)	1987-01-22
KR940003495B1 (ko)	1994-04-23
DE3623853A1 (de)	1987-01-29
NZ216828A (en)	1989-11-28
SE468594B (sv)	1993-02-15
CZ277823B6 (en)	1993-06-16
IE59275B1 (en)	1994-02-09
GB2178037B (en)	1989-07-26
GB8617293D0 (en)	1986-08-20
HUT41814A (en)	1987-05-28
ES2000346A6 (es)	1988-02-16
KR870001228A (ko)	1987-03-12
JPS6230755A (ja)	1987-02-09
FR2585019A1 (fr)	1987-01-23
HU198087B (en)	1989-07-28
ZA865262B (en)	1987-03-25
NO169014B (no)	1992-01-20
CN85103908A (zh)	1986-11-05
FR2585019B1 (fr)	1989-07-13
CN1026984C (zh)	1994-12-14
SE8603099D0 (sv)	1986-07-11
FI82929C (fi)	1991-05-10
US4738980A (en)	1988-04-19
AT386822B (de)	1988-10-25
PH23459A (en)	1989-08-07
GR861840B (en)	1986-11-18
NO862861L (no)	1987-01-19
FI82929B (fi)	1991-01-31
IL79401A0 (en)	1986-10-31

Publication	Publication Date	Title
CS541186A3 (en)	1992-09-16	Distamycin derivatives and process for preparing thereof
YU11988A (en)	1989-08-31	Process for obtaining b avermectines and their derivatives
GB2177089B (en)	1989-07-19	Thiazolidinecarboxylic acid derivatives and process for preparing same
ZA865263B (en)	1987-03-25	Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation
GR3002032T3 (en)	1992-12-30	Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation
HUT41715A (en)	1987-05-28	Process for preparing n-substituted alpha-aminoacids and derivatives thereof
GB2178036B (en)	1989-08-16	Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation
HUT42441A (en)	1987-07-28	Process for preparing indolyl- and indazolyl-carboxamide derivatives
CS264686A3 (en)	1992-11-18	Aminoketone derivatives and process for preparing thereof
GB2199325B (en)	1990-04-25	Process for preparing 16-dehydro-20-oxopregnane derivatives and such derivatives
DE3661830D1 (en)	1989-02-23	2,4-dichlorothiazole derivatives and process for their preparation
GR862198B (en)	1986-10-31	Propionamidine derivatives and process for their preparation
ZA891183B (en)	1989-11-29	Novel 16-homo-piperidino-androstane derivatives and processes for their preparation
PL249198A1 (en)	1986-02-25	Process for preparing n-phosphonmethylglycine and its derivatives
HUT40657A (en)	1987-01-28	Process for preparing imidazo-isoquinoline and imidazo-thieno-pyridine derivatives
GB2201417B (en)	1990-10-31	Piperazine derivatives and process for the preparation thereof
DE3662097D1 (en)	1989-03-23	4-mercaptobenzonitriles and process for their preparation
HUT42066A (en)	1987-06-29	Process for preparing 4-phenyl-propyl-indole derivatives
ZA869639B (en)	1987-08-26	Aromatic bismaleimide derivatives and process for preparing same
GB2185257B (en)	1989-10-18	10 beta-alkynyl-4, 9(11)-estradiene derivatives and process for their preparation
DE3661635D1 (en)	1989-02-09	Ketosultams and process for their preparation
GB2185258B (en)	1989-10-18	10 beta-alkynyl estrene derivatives and process for their preparation
ZA881990B (en)	1988-09-12	Dicyanoethylaryl derivatives and process for their preparation
HUT42448A (en)	1987-07-28	Process for preparing tetrahydro-4-hydroxy-isoquinoline derivatives
HUT41378A (en)	1987-04-28	Process for preparing benzoyl-ester derivatives