CS564681A2 - Zpusob vyroby racemickych nebo opticky aktivnich 5 substituovanych oxazolidin 2,4 dionu - Google Patents

Zpusob vyroby racemickych nebo opticky aktivnich 5 substituovanych oxazolidin 2,4 dionu

Info

Publication number: CS564681A2
Authority: CS; Czechoslovakia
Prior art keywords: substituovanych; racemickych; opticky; dionu; aktivnich
Prior art date: 1980-07-28

Application number

CS815646A

Other languages

English (en)

Other versions

CS237320B2 (en

Inventor

Rodney C Schnur

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-28

Filing date

1981-07-23

Publication date

1984-12-14

1981-01-02 Priority claimed from US06/222,202 external-priority patent/US4367234A/en

1981-04-23 Priority claimed from US06/252,961 external-priority patent/US4332952A/en

1981-04-23 Priority claimed from US06/252,962 external-priority patent/US4342771A/en

1981-07-23 Application filed by Pfizer filed Critical Pfizer

1981-07-23 Priority to CS838032A priority Critical patent/CS237346B2/cs

1983-10-31 Priority to CS838034A priority patent/CS237348B2/cs

1984-12-14 Publication of CS564681A2 publication Critical patent/CS564681A2/cs

1985-07-16 Publication of CS237320B2 publication Critical patent/CS237320B2/cs

Links

241001611408 Nebo Species 0.000 title 1
HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 title 1
229960000649 oxyphenbutazone Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS815646A 1980-07-28 1981-07-23 Processing of racemic or opticaly active 5-substituted oxazolidine-2,4-dione CS237320B2 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CS838032A CS237346B2 (en)	1980-07-28	1981-07-23	Processing of racemic or opticaly active 5-substituted oxazolidine-2,4-dione
CS838034A CS237348B2 (en)	1980-07-28	1983-10-31	Processing of racemic or optically active 5-substituted oxazolidine-2,4-dione

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US17320680A	1980-07-28	1980-07-28
US06/222,202 US4367234A (en)	1980-07-28	1981-01-02	Hypoglycemic 5-substituted oxazolidine-2,4-diones
US06/252,961 US4332952A (en)	1980-07-28	1981-04-23	Hypoglycemic 5-substituted oxazolidine-2,4-diones
US06/252,962 US4342771A (en)	1981-01-02	1981-04-23	Hypoglycemic 5-substituted oxazolidine-2,4-diones

Publications (2)

Publication Number	Publication Date
CS564681A2 true CS564681A2 (en)	1984-12-14
CS237320B2 CS237320B2 (en)	1985-07-16

Family

ID=27497044

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS815646A CS237320B2 (en)	1980-07-28	1981-07-23	Processing of racemic or opticaly active 5-substituted oxazolidine-2,4-dione

Country Status (29)

Country	Link
JP (1)	JPS5764692A (cs)
AR (3)	AR230281A1 (cs)
AU (2)	AU526733B2 (cs)
CA (1)	CA1161843A (cs)
CH (1)	CH653029A5 (cs)
CS (1)	CS237320B2 (cs)
DD (1)	DD202555A5 (cs)
DE (1)	DE3129275A1 (cs)
DK (1)	DK152650C (cs)
ES (4)	ES8301976A1 (cs)
FI (1)	FI75820C (cs)
FR (1)	FR2487350B1 (cs)
GB (5)	GB2080803B (cs)
GR (1)	GR75303B (cs)
HK (1)	HK43886A (cs)
IE (1)	IE51662B1 (cs)
IL (1)	IL63424A (cs)
IT (1)	IT1138111B (cs)
KE (1)	KE3624A (cs)
LU (1)	LU83513A1 (cs)
MY (1)	MY8600596A (cs)
NO (1)	NO812559L (cs)
NZ (1)	NZ197854A (cs)
PH (2)	PH21172A (cs)
PL (1)	PL133220B1 (cs)
PT (1)	PT73436B (cs)
SE (1)	SE461039B (cs)
SG (1)	SG56656G (cs)
YU (2)	YU185481A (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695634A (en) *	1981-01-02	1987-09-22	Pfizer Inc.	Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) *	1981-01-02	1987-08-25	Pfizer Inc.	Hypoglycemic 5-substituted oxazolidine 2,4-diones
GR78120B (cs) *	1982-03-01	1984-09-26	Pfizer
DE3233089A1 (de) *	1982-09-07	1984-03-08	Basf Ag, 6700 Ludwigshafen	Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
JPS59152382A (ja) *	1983-02-18	1984-08-31	Tanabe Seiyaku Co Ltd	フリルオキサゾリル酢酸誘導体
HU203330B (en) *	1987-06-10	1991-07-29	Pfizer	Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
TW403748B (en)	1994-11-02	2000-09-01	Takeda Chemical Industries Ltd	An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
IL117208A0 (en) *	1995-02-23	1996-06-18	Nissan Chemical Ind Ltd	Indole type thiazolidines
AU2004315596B2 (en) *	2003-08-29	2011-11-24	President And Fellows Of Harvard College	Inhibitors of cellular necrosis
ES2569660T3 (es) *	2007-06-08	2016-05-12	Mannkind Corporation	Inhibidores de la IRE-1alfa
WO2010075561A1 (en)	2008-12-23	2010-07-01	President And Fellows Of Harvard College	Small molecule inhibitors of necroptosis
WO2014145022A1 (en)	2013-03-15	2014-09-18	President And Fellows Of Harvard College	Hybrid necroptosis inhibitors
WO2016094846A1 (en)	2014-12-11	2016-06-16	President And Fellows Of Harvard College	Inhibitors of cellular necrosis and related methods

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DE834992C (de) *	1946-09-16	1952-03-27	British Schering Res Lab Ltd	Verfahren zur Herstellung von N-Alkyl- oder N-Aralkylderivaten der Oxazolidin-2, 4-dine
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1981
- 1981-07-22 GB GB8122524A patent/GB2080803B/en not_active Expired
- 1981-07-22 SG SG305/86A patent/SG56656G/en unknown
- 1981-07-23 CS CS815646A patent/CS237320B2/cs unknown
- 1981-07-23 PL PL1981232330A patent/PL133220B1/pl unknown
- 1981-07-24 DE DE19813129275 patent/DE3129275A1/de active Granted
- 1981-07-24 SE SE8104543A patent/SE461039B/sv not_active IP Right Cessation
- 1981-07-27 CA CA000382568A patent/CA1161843A/en not_active Expired
- 1981-07-27 IE IE1696/81A patent/IE51662B1/en unknown
- 1981-07-27 DD DD81232129A patent/DD202555A5/de unknown
- 1981-07-27 GR GR65638A patent/GR75303B/el unknown
- 1981-07-27 PH PH25966A patent/PH21172A/en unknown
- 1981-07-27 YU YU01854/81A patent/YU185481A/xx unknown
- 1981-07-27 JP JP56117572A patent/JPS5764692A/ja active Granted
- 1981-07-27 FR FR8114542A patent/FR2487350B1/fr not_active Expired
- 1981-07-27 NO NO812559A patent/NO812559L/no unknown
- 1981-07-27 IL IL63424A patent/IL63424A/xx unknown
- 1981-07-27 IT IT23176/81A patent/IT1138111B/it active
- 1981-07-27 ES ES504321A patent/ES8301976A1/es not_active Expired
- 1981-07-27 AU AU73436/81A patent/AU526733B2/en not_active Ceased
- 1981-07-27 CH CH4878/81A patent/CH653029A5/fr not_active IP Right Cessation
- 1981-07-27 DK DK334781A patent/DK152650C/da not_active IP Right Cessation
- 1981-07-27 LU LU83513A patent/LU83513A1/fr unknown
- 1981-07-27 PT PT73436A patent/PT73436B/pt unknown
- 1981-07-27 FI FI812339A patent/FI75820C/fi not_active IP Right Cessation
- 1981-07-27 NZ NZ197854A patent/NZ197854A/en unknown
1982
- 1982-04-27 AR AR289216A patent/AR230281A1/es active
- 1982-04-27 AR AR289217A patent/AR229958A1/es active
- 1982-04-27 AR AR289218A patent/AR230053A1/es active
- 1982-07-23 ES ES514314A patent/ES8306147A1/es not_active Expired
- 1982-07-23 ES ES514316A patent/ES514316A0/es active Granted
- 1982-07-23 ES ES514315A patent/ES8306148A1/es not_active Expired
- 1982-11-02 AU AU90100/82A patent/AU548932B2/en not_active Ceased
1983
- 1983-01-03 PH PH28343A patent/PH18925A/en unknown
- 1983-04-22 YU YU00919/83A patent/YU91983A/xx unknown
- 1983-06-24 GB GB08317146A patent/GB2131422B/en not_active Expired
- 1983-06-24 GB GB08317142A patent/GB2134104B/en not_active Expired
- 1983-06-24 GB GB08317143A patent/GB2134105B/en not_active Expired
- 1983-06-24 GB GB08317147A patent/GB2128184B/en not_active Expired
1986
- 1986-04-04 KE KE3624A patent/KE3624A/xx unknown
- 1986-06-09 HK HK438/86A patent/HK43886A/xx unknown
- 1986-12-30 MY MY596/86A patent/MY8600596A/xx unknown

Also Published As

Publication number	Publication date
CH653029A5 (fr)	1985-12-13
MY8600596A (en)	1986-12-31
GB2134104B (en)	1985-02-06
FR2487350B1 (fr)	1986-04-04
PL232330A1 (en)	1983-09-26
IE811696L (en)	1982-01-28
PT73436B (en)	1983-09-01
ES514314A0 (es)	1983-05-01
PL133220B1 (en)	1985-05-31
CA1161843A (en)	1984-02-07
AU526733B2 (en)	1983-01-27
YU185481A (en)	1983-10-31
DD202555A5 (de)	1983-09-21
SG56656G (en)	1987-03-27
GB2131422B (en)	1984-12-05
AU9010082A (en)	1983-03-03
FI75820C (fi)	1988-08-08
AR230053A1 (es)	1984-02-29
IE51662B1 (en)	1987-02-04
LU83513A1 (fr)	1982-02-17
GB2131422A (en)	1984-06-20
ES504321A0 (es)	1983-01-01
IL63424A (en)	1985-09-29
PH21172A (en)	1987-08-07
GB8317146D0 (en)	1983-07-27
DE3129275A1 (de)	1982-04-22
YU91983A (en)	1983-10-31
GB2128184A (en)	1984-04-26
AU548932B2 (en)	1986-01-09
GB8317142D0 (en)	1983-07-27
KE3624A (en)	1986-05-16
FI812339L (fi)	1982-01-29
GB8317147D0 (en)	1983-07-27
PT73436A (en)	1981-08-01
NO812559L (no)	1982-01-29
IT1138111B (it)	1986-09-17
GR75303B (cs)	1984-07-13
DK334781A (da)	1982-02-25
GB8317143D0 (en)	1983-07-27
NZ197854A (en)	1984-11-09
JPS6335632B2 (cs)	1988-07-15
FR2487350A1 (fr)	1982-01-29
SE461039B (sv)	1989-12-18
IT8123176A0 (it)	1981-07-27
ES8305760A1 (es)	1983-04-16
AU7343681A (en)	1982-02-04
ES8301976A1 (es)	1983-01-01
IL63424A0 (en)	1981-10-30
AR230281A1 (es)	1984-03-01
DK152650C (da)	1988-08-29
PH18925A (en)	1985-11-11
FI75820B (fi)	1988-04-29
DK152650B (da)	1988-04-05
ES514315A0 (es)	1983-05-01
GB2080803B (en)	1984-01-18
AR229958A1 (es)	1984-01-31
GB2134104A (en)	1984-08-08
GB2128184B (en)	1984-08-15
DE3129275C2 (cs)	1987-10-15
ES514316A0 (es)	1983-04-16
JPS5764692A (en)	1982-04-19
CS237320B2 (en)	1985-07-16
SE8104543L (sv)	1982-01-29
GB2134105A (en)	1984-08-08
HK43886A (en)	1986-06-20
ES8306147A1 (es)	1983-05-01
GB2134105B (en)	1985-01-16
ES8306148A1 (es)	1983-05-01
GB2080803A (en)	1982-02-10

Publication	Publication Date	Title
GB2064520B (en)	1984-07-04	A-aryl-1h-1,2,4-triazole-1-ethanols
CS564581A2 (en)	1985-09-17	Zpusob vyroby racemickych nebo opticky aktivnich 5-substituovanych oxazolidin-2,4-dionu
JPS5753490A (en)	1982-03-30	5'-aminoalkyl-4',4,8-trialkylpsoralens
CS819581A2 (en)	1985-08-15	Vedeni dulniho dobyvaciho stroje, zejmena uhelneho pluhu
GB2068382B (en)	1984-02-29	25-hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
JPS57140740A (en)	1982-08-31	Novel 1,8-dihydroxy-9-anthrone compound
CS803483A2 (en)	1984-12-14	Zpusob vyroby racemickych nebo opticky aktivnich 5 substituovanych oxazolidin 2,4 dionu
PH15530A (en)	1983-02-09	1,2,3,5 tetrahydroimidazothienopyrimidin 2-ones
GB2058767B (en)	1983-06-08	4'-substituted-4,5',8-trialklpsoralens
GB2073752B (en)	1984-02-22	2,6-diaminobularines
GB2075012B (en)	1984-02-15	4,1-benzoxazepines
PH16525A (en)	1983-11-10	9beta,11beta-epoxy-5beta-corticoids
GB2135303B (en)	1985-04-03	3,5-dinitrophthalimides
GB2044770B (en)	1983-05-11	24,24 - difluoro- 25 - hydroxycholecalciferol
NZ193666A (en)	1982-12-21	3-aryl-2-(2,3-dihydrothiazol-2-ylidene)-3-oxopropionitriles
PT73240A (en)	1981-07-01	2,3-bis-hydroxybenzyl-derivatives
ZW6581A1 (en)	1981-07-01	2,5-disubstituted-4-pirimidones
NZ197556A (en)	1983-09-30	1,1 -alkylenediiminobis(4-( -aminoalkylamino)-anthraquinones
PH18722A (en)	1985-09-11	Crystalline 1,1-dioxopeniciliianoyloxymethyl-6-(o- -phenylacetamido)penicillante
JPS57116050A (en)	1982-07-19	2,4-diamino-5-benzylpyrimidine
CS673081A2 (en)	1988-07-15	Cytokininovy, membranove aktivni prostredek
GB2086387B (en)	1984-07-18	1,8-dihydroxy-9-anthrones
NZ196229A (en)	1983-02-15	2-acylpiperidino-4-amino-6,7-dimethoxyquinazolines
GB2080791B (en)	1984-02-22	1,4-benzoxazines
ZA804183B (en)	1981-08-26	1,2,4-thiadiazolyloxyphenylureas