CS9100586A2 - Rebeccamycinic analogue, method of its preparation and pharmaceutical application - Google Patents

Rebeccamycinic analogue, method of its preparation and pharmaceutical application

Info

Publication number
CS9100586A2
CS9100586A2 CS91586A CS58691A CS9100586A2 CS 9100586 A2 CS9100586 A2 CS 9100586A2 CS 91586 A CS91586 A CS 91586A CS 58691 A CS58691 A CS 58691A CS 9100586 A2 CS9100586 A2 CS 9100586A2
Authority
CS
Czechoslovakia
Prior art keywords
rebeccamycinic
analogue
preparation
pharmaceutical application
rebeccamycin
Prior art date
Application number
CS91586A
Other languages
English (en)
Inventor
King Sing Lam
Daniel R Schroeder
Jacqueline Mattei
Salvatore Forenza
James A Matson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CS9100586A2 publication Critical patent/CS9100586A2/cs
Publication of CZ279307B6 publication Critical patent/CZ279307B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Ceramic Products (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
CS91586A 1990-03-06 1991-03-06 Rebeccamycinový analog, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje CZ279307B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48943090A 1990-03-06 1990-03-06
US64875191A 1991-02-05 1991-02-05

Publications (2)

Publication Number Publication Date
CS9100586A2 true CS9100586A2 (en) 1991-10-15
CZ279307B6 CZ279307B6 (cs) 1995-04-12

Family

ID=27049711

Country Status (22)

Country Link
US (1) US5468849A (cs)
EP (1) EP0450327B1 (cs)
JP (1) JPH0780899B2 (cs)
KR (1) KR940005657B1 (cs)
AT (1) ATE138926T1 (cs)
AU (1) AU623050B2 (cs)
CY (1) CY1941A (cs)
CZ (1) CZ279307B6 (cs)
DE (1) DE69119964T2 (cs)
DK (1) DK0450327T3 (cs)
ES (1) ES2088439T3 (cs)
FI (1) FI102376B1 (cs)
GR (1) GR3020163T3 (cs)
HK (1) HK181496A (cs)
HU (1) HU211055B (cs)
IE (1) IE910737A1 (cs)
IL (1) IL97233A (cs)
NO (1) NO179555C (cs)
PT (1) PT96943B (cs)
SG (1) SG63555A1 (cs)
TW (1) TW232698B (cs)
YU (1) YU39391A (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
ATE175873T1 (de) * 1992-03-20 1999-02-15 Wellcome Found Weitere indolderivate mit antiviraler wirkung
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
WO1995034663A1 (en) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
BR9711306A (pt) * 1996-08-22 1999-08-17 Bristol Myers Squibb Co Amino a-Úcar citotÄxico e derivados de a-Úcar correlatos de indolopirrolocarbazÄis
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) * 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
IL157909A0 (en) * 2001-03-22 2004-03-28 Bristol Myers Squibb Co Indolopyrrolocarbazole derivatives and pharmaceutical compositions containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition

Also Published As

Publication number Publication date
AU7261691A (en) 1991-09-12
CY1941A (en) 1997-05-16
US5468849A (en) 1995-11-21
ATE138926T1 (de) 1996-06-15
FI102376B (fi) 1998-11-30
PT96943A (pt) 1991-10-31
NO910855D0 (no) 1991-03-05
DE69119964D1 (de) 1996-07-11
ES2088439T3 (es) 1996-08-16
JPH0789981A (ja) 1995-04-04
FI911047A7 (fi) 1991-09-07
FI911047A0 (fi) 1991-03-01
EP0450327B1 (en) 1996-06-05
NO179555B (no) 1996-07-22
HU211055B (en) 1995-10-30
IL97233A (en) 1995-03-30
KR940005657B1 (ko) 1994-06-22
HK181496A (en) 1996-10-04
IL97233A0 (en) 1992-05-25
HUT61601A (en) 1993-01-28
PT96943B (pt) 1998-07-31
NO910855L (no) 1991-09-09
CZ279307B6 (cs) 1995-04-12
AU623050B2 (en) 1992-04-30
NO179555C (no) 1996-10-30
KR910016934A (ko) 1991-11-05
DK0450327T3 (da) 1996-06-24
TW232698B (cs) 1994-10-21
FI102376B1 (fi) 1998-11-30
SG63555A1 (en) 1999-03-30
IE910737A1 (en) 1991-09-11
EP0450327A1 (en) 1991-10-09
GR3020163T3 (en) 1996-09-30
HU910716D0 (en) 1991-09-30
YU39391A (sh) 1994-01-20
DE69119964T2 (de) 1997-02-06
JPH0780899B2 (ja) 1995-08-30

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