PT96943A - Processo para a preparacao de analogos de rebecamicina e de composicoes farmac euticas que os contem - Google Patents

Processo para a preparacao de analogos de rebecamicina e de composicoes farmac euticas que os contem

Info

Publication number
PT96943A
PT96943A PT96943A PT9694391A PT96943A PT 96943 A PT96943 A PT 96943A PT 96943 A PT96943 A PT 96943A PT 9694391 A PT9694391 A PT 9694391A PT 96943 A PT96943 A PT 96943A
Authority
PT
Portugal
Prior art keywords
analogs
farmac
rebecamycin
eutic
preparation
Prior art date
Application number
PT96943A
Other languages
English (en)
Other versions
PT96943B (pt
Inventor
Kin Sing Lam
Daniel R Schroeder
Jacqueline Mattei
Salvatore Forenza
James A Matson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT96943A publication Critical patent/PT96943A/pt
Publication of PT96943B publication Critical patent/PT96943B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Ceramic Products (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
PT96943A 1990-03-06 1991-03-05 Processo para a preparacao de analogos de rebecamicina e de composicoes farmac euticas que os contem PT96943B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48943090A 1990-03-06 1990-03-06
US64875191A 1991-02-05 1991-02-05

Publications (2)

Publication Number Publication Date
PT96943A true PT96943A (pt) 1991-10-31
PT96943B PT96943B (pt) 1998-07-31

Family

ID=27049711

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96943A PT96943B (pt) 1990-03-06 1991-03-05 Processo para a preparacao de analogos de rebecamicina e de composicoes farmac euticas que os contem

Country Status (22)

Country Link
US (1) US5468849A (pt)
EP (1) EP0450327B1 (pt)
JP (1) JPH0780899B2 (pt)
KR (1) KR940005657B1 (pt)
AT (1) ATE138926T1 (pt)
AU (1) AU623050B2 (pt)
CY (1) CY1941A (pt)
CZ (1) CZ279307B6 (pt)
DE (1) DE69119964T2 (pt)
DK (1) DK0450327T3 (pt)
ES (1) ES2088439T3 (pt)
FI (1) FI102376B (pt)
GR (1) GR3020163T3 (pt)
HK (1) HK181496A (pt)
HU (1) HU211055B (pt)
IE (1) IE910737A1 (pt)
IL (1) IL97233A (pt)
NO (1) NO179555C (pt)
PT (1) PT96943B (pt)
SG (1) SG63555A1 (pt)
TW (1) TW232698B (pt)
YU (1) YU39391A (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5547976A (en) * 1992-03-20 1996-08-20 Burroughs Wellcome Co. Further indole derivatives with antiviral activity
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
DE69531686T2 (de) * 1994-06-13 2004-07-15 Banyu Pharmaceutical Co., Ltd. Glycosyltransferase kodierendes gen und seine verwendung
NZ333536A (en) * 1996-08-22 1999-10-28 Bristol Myers Squibb Co Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles, and use as antitumour agents
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) * 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition

Also Published As

Publication number Publication date
JPH0780899B2 (ja) 1995-08-30
ATE138926T1 (de) 1996-06-15
FI102376B1 (fi) 1998-11-30
NO910855D0 (no) 1991-03-05
FI911047A0 (fi) 1991-03-01
CY1941A (en) 1997-05-16
HK181496A (en) 1996-10-04
CZ279307B6 (cs) 1995-04-12
ES2088439T3 (es) 1996-08-16
DK0450327T3 (da) 1996-06-24
AU7261691A (en) 1991-09-12
US5468849A (en) 1995-11-21
HUT61601A (en) 1993-01-28
IL97233A0 (en) 1992-05-25
FI102376B (fi) 1998-11-30
NO179555B (no) 1996-07-22
NO179555C (no) 1996-10-30
DE69119964D1 (de) 1996-07-11
EP0450327B1 (en) 1996-06-05
SG63555A1 (en) 1999-03-30
EP0450327A1 (en) 1991-10-09
DE69119964T2 (de) 1997-02-06
KR940005657B1 (ko) 1994-06-22
NO910855L (no) 1991-09-09
HU211055B (en) 1995-10-30
HU910716D0 (en) 1991-09-30
CS9100586A2 (en) 1991-10-15
JPH0789981A (ja) 1995-04-04
AU623050B2 (en) 1992-04-30
TW232698B (pt) 1994-10-21
YU39391A (sh) 1994-01-20
FI911047A7 (fi) 1991-09-07
KR910016934A (ko) 1991-11-05
IL97233A (en) 1995-03-30
GR3020163T3 (en) 1996-09-30
IE910737A1 (en) 1991-09-11
PT96943B (pt) 1998-07-31

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910708

FG3A Patent granted, date of granting

Effective date: 19980414

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20071015