CS955382A2 - Zpusob vyroby ergolinylovych sloucenin substituovanych v poloze 8 dusikem - Google Patents

Zpusob vyroby ergolinylovych sloucenin substituovanych v poloze 8 dusikem

Info

Publication number: CS955382A2
Authority: CS; Czechoslovakia
Prior art keywords: sub; sup; substituovanych; sloucenin; ergolinylovych
Prior art date: 1981-12-23

Application number

CS829553A

Other languages

English (en)

Other versions

CS235098B2 (en

Inventor

Gregor Dr Haffer

Gerhard Dr Sauer

Helmut Dr Wachtel

Herbert Dr Schneider

Ulrich Dr Eder

Hans Peter Dr Lorenz

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-23

Filing date

1982-12-22

Publication date

1984-02-13

1982-12-22 Application filed by Schering Ag filed Critical Schering Ag

1984-02-13 Publication of CS955382A2 publication Critical patent/CS955382A2/cs

1985-04-16 Publication of CS235098B2 publication Critical patent/CS235098B2/cs

Links

239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS829553A 1981-12-23 1982-12-22 Method of orgolinyl compounds production ortosubstituted by nitrogen CS235098B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19813151912 DE3151912A1 (de)	1981-12-23	1981-12-23	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
CS955382A2 true CS955382A2 (en)	1984-02-13
CS235098B2 CS235098B2 (en)	1985-04-16

Family

ID=6150011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS829553A CS235098B2 (en)	1981-12-23	1982-12-22	Method of orgolinyl compounds production ortosubstituted by nitrogen

Country Status (18)

Country	Link
US (1)	US4826852A (cs)
EP (2)	EP0185392A3 (cs)
JP (1)	JPS58150593A (cs)
AT (1)	ATE27458T1 (cs)
AU (1)	AU570621B2 (cs)
CA (1)	CA1319684C (cs)
CS (1)	CS235098B2 (cs)
DD (1)	DD208619A5 (cs)
DE (2)	DE3151912A1 (cs)
DK (1)	DK163240C (cs)
ES (1)	ES8400115A1 (cs)
GR (1)	GR78410B (cs)
HU (1)	HU191623B (cs)
IE (1)	IE56541B1 (cs)
IL (1)	IL67545A (cs)
RO (2)	RO87945A (cs)
SU (1)	SU1313348A3 (cs)
YU (1)	YU282382A (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU196399B (en) *	1983-02-16	1988-11-28	Sandoz Ag	Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
NL193541C (nl) *	1984-01-12	2000-01-04	Novartis Ag	8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3413659A1 (de) *	1984-04-09	1985-10-17	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 2-substituierte ergolin-derivate
DE3413657A1 (de) *	1984-04-09	1985-10-17	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ergoline
CH666035A5 (de) *	1984-12-24	1988-06-30	Sandoz Ag	8-alpha-acylaminoergolene.
DE3528584A1 (de) *	1985-08-06	1987-02-19	Schering Ag	Neue 1-alkyl-ergolin-thioharnstoffderivate
DE3528576A1 (de) *	1985-08-06	1987-02-19	Schering Ag	Verfahren zur herstellung von ergolin-thioharnstoffen
DE3533675A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-brom-ergolinderivate
DE3533672A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-substituierte ergolinderivate
DE3535929A1 (de) *	1985-10-04	1987-04-09	Schering Ag	1,2-disubstituierte ergolinderivate
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US5229129A (en) *	1989-07-12	1993-07-20	Cygnus Therapeutic Systems	Transdermal administration of lisuride
US5252335A (en) *	1989-07-12	1993-10-12	Cygnus Therapeutic Systems	Transdermal administration of lisuride
GB0307377D0 (en) *	2003-03-31	2003-05-07	Merad Pharmaceuticals Ltd	Ergoline derivatives
US20060140820A1 (en)	2004-12-28	2006-06-29	Udo Mattern	Use of a container of an inorganic additive containing plastic material
DK2068825T3 (da)	2006-10-04	2011-05-16	M & P Patent Ag	Kontrolleret frisætningstilførselssystem til nasal påføring af neurotransmittere
EP2083008A1 (en) *	2007-12-07	2009-07-29	Axxonis Pharma AG	Ergoline derivatives as selective radical scavengers for neurons
US20130040923A1 (en)	2011-05-13	2013-02-14	Trimel Pharmaceuticals Corporation	Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en)	2011-05-13	2017-09-12	Acerus Pharmaceuticals Srl	Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US20130045958A1 (en)	2011-05-13	2013-02-21	Trimel Pharmaceuticals Corporation	Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US11744838B2 (en)	2013-03-15	2023-09-05	Acerus Biopharma Inc.	Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2533698A (en) *		1950-12-12		Urethanes containing the lysergic
US2864822A (en) *	1956-10-22	1958-12-16	Lilly Co Eli	9-amino-7-methyl-belta10-ergolene and derivatives thereof
DE1212097B (de) *	1962-09-05	1966-03-10	Sdruzeni Podnikuu Pro Zdravotn	Verfahren zur Herstellung von N-[D-1, 6-Dimethylisoergolenyl-(8)]-N', N'-dialkylharnstoffen
FR1339406A (fr) *	1962-11-23	1963-10-04	Farmaceutici Italia	Procédé de préparation de nouveaux dérivés de 6-méthylergoline pi et de 1, 6-diméthylergoline pi
BR6915443D0 (pt) *	1969-07-18	1973-03-13	Farmaceutici Italia	Processo para a preparacao de derivados de ergolina
CH573936A5 (cs) *	1971-08-05	1976-03-31	Spofa Vereinigte Pharma Werke
US4348392A (en) *	1974-07-19	1982-09-07	Sandoz Ltd.	8α-Substituted ergoline-I derivatives
GB1573621A (en) *	1976-01-02	1980-08-28	Sandoz Ltd	Acylated 6-methyl-8a-amino-ergoline i compounds
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
DE2656344A1 (de) *	1975-12-23	1977-07-07	Sandoz Ag	Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
EP0021206B1 (de) *	1979-06-13	1983-06-22	Schering Aktiengesellschaft	Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
CH654838A5 (fr) *	1980-07-25	1986-03-14	Sandoz Ag	Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen.
DE3135305C2 (de) *	1981-09-03	1983-07-21	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen
GB2112382B (en) *	1981-11-06	1985-03-06	Erba Farmitalia	Ergoline derivatives
DE3533675A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-brom-ergolinderivate

1981
- 1981-12-23 DE DE19813151912 patent/DE3151912A1/de not_active Withdrawn
1982
- 1982-12-09 SU SU823519900A patent/SU1313348A3/ru active
- 1982-12-14 AU AU91468/82A patent/AU570621B2/en not_active Ceased
- 1982-12-15 DD DD82246012A patent/DD208619A5/de unknown
- 1982-12-20 YU YU02823/82A patent/YU282382A/xx unknown
- 1982-12-20 RO RO82113566A patent/RO87945A/ro unknown
- 1982-12-20 RO RO109398A patent/RO85270B/ro unknown
- 1982-12-22 DK DK566982A patent/DK163240C/da not_active IP Right Cessation
- 1982-12-22 CS CS829553A patent/CS235098B2/cs unknown
- 1982-12-22 IE IE3051/82A patent/IE56541B1/en not_active IP Right Cessation
- 1982-12-22 CA CA000418299A patent/CA1319684C/en not_active Expired - Fee Related
- 1982-12-22 IL IL67545A patent/IL67545A/xx not_active IP Right Cessation
- 1982-12-22 HU HU824138A patent/HU191623B/hu not_active IP Right Cessation
- 1982-12-22 ES ES518482A patent/ES8400115A1/es not_active Expired
- 1982-12-22 GR GR70153A patent/GR78410B/el unknown
- 1982-12-23 AT AT82730152T patent/ATE27458T1/de not_active IP Right Cessation
- 1982-12-23 EP EP85116397A patent/EP0185392A3/en not_active Withdrawn
- 1982-12-23 EP EP82730152A patent/EP0082808B1/en not_active Expired
- 1982-12-23 DE DE8282730152T patent/DE3276433D1/de not_active Expired
- 1982-12-23 JP JP57225123A patent/JPS58150593A/ja active Granted
1986
- 1986-06-26 US US06/878,762 patent/US4826852A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU570621B2 (en)	1988-03-24
RO87945A (ro)	1986-09-30
DE3151912A1 (de)	1983-06-30
DK163240C (da)	1992-06-29
DK566982A (da)	1983-06-24
US4826852A (en)	1989-05-02
EP0185392A2 (en)	1986-06-25
RO85270B (ro)	1984-10-30
ATE27458T1 (de)	1987-06-15
SU1313348A3 (ru)	1987-05-23
JPS58150593A (ja)	1983-09-07
CS235098B2 (en)	1985-04-16
EP0082808B1 (en)	1987-05-27
EP0082808A1 (en)	1983-06-29
IE56541B1 (en)	1991-08-28
DK163240B (da)	1992-02-10
JPH0352463B2 (cs)	1991-08-12
IE823051L (en)	1983-06-23
HU191623B (en)	1987-03-30
DE3276433D1 (en)	1987-07-02
IL67545A0 (en)	1983-05-15
DD208619A5 (de)	1984-04-04
CA1319684C (en)	1993-06-29
GR78410B (cs)	1984-09-27
EP0185392A3 (en)	1987-05-13
IL67545A (en)	1986-09-30
RO85270A (ro)	1984-09-29
ES518482A0 (es)	1983-11-01
AU9146882A (en)	1983-06-30
ES8400115A1 (es)	1983-11-01
YU282382A (en)	1986-12-31

Publication	Publication Date	Title
AU570621B2 (en)	1988-03-24	8-n-substituted ergolinyl compounds
ZA857824B (en)	1986-05-28	Substituted propane-phosphonous acid compounds
EP0057546A3 (en)	1982-11-03	Sulfonylurea n-oxides
GB2093833B (en)	1985-01-23	5,5'-azobis-salicylic acid its salts and hydrates as pahrmaceuticals
EP0207158A4 (en)	1987-07-09	ANTIASTHMA PREPARATION CONTAINING 8,11,14,17-EICOSATETRAENOIC ACID.
ES8801919A1 (es)	1988-03-01	Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos
NO163856C (no)	1990-08-08	Fremgangsmaate til fremstilling av ikke-toksiske salter av6-metyl-3,4-dihydro-1,2,3-oksatiazin-4-on-2,2-dioksyd.
PH21229A (en)	1987-08-21	Substituted 1,8-naphthyridinones, useful as anti-allergic agents
EP0200391A3 (en)	1987-06-03	Substituted 2,3,4,9-tetrahydro-1h-carbazole-1-acetic acid derivatives
ZA822854B (en)	1983-03-30	4'-halo-substituted sucrose derivatives
AU575022B2 (en)	1988-07-21	Antiviral 5-halovinyl-2'-deoxyuridines
AU561700B2 (en)	1987-05-14	2h(1)benzoxepino(5,4-b)1,4-oxazines
GR79822B (cs)	1984-10-31
DE3275091D1 (en)	1987-02-19	Derivatives of m.139,603 useful as growth promotors
PT81101A (en)	1985-10-01	7-oxo-4-thia-1-azabicyclo<3,2,o>hept-2-ene-derivatives
ZA854877B (en)	1986-08-27	4h-pyrimido(2,1a)isoquinolin-4-one derivatives
ZA88145B (en)	1988-07-12	2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives
AU8790882A (en)	1983-03-31	6,6-diiodopenicillanic acid
ES8202811A1 (es)	1982-03-01	Un procedimiento para la preparacion de derivados de benzo (1,4) dioxina
FI92394B (fi)	1994-07-29	5-Amino-1,2,4-tiadiatsol-3-yyli-iminokarbonyyliyhdiste
PH25608A (en)	1991-08-08	3-amino-tetrahydro-isoquinoline
IE841800L (en)	1985-01-15	15,16-methylene-17-pregna-4,5-diene-21-carboxylic acid salts
IE850107L (en)	1985-07-18	1,4-dihydropyridinedicarboxylic acid derivatives.
AU8041982A (en)	1982-08-19	11,15-dihydroxy-9-oxo-13,18-prostadienoic acid
CS775988A1 (en)	1989-08-14	7-chloro-1-(2,4 dinitrophynel)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxyl acid