DK566982A - Hidtil ukendte i 8-stilling nitrogensubstituerede ergolinylforbindelser, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel - Google Patents

Hidtil ukendte i 8-stilling nitrogensubstituerede ergolinylforbindelser, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel Download PDF

Info

Publication number: DK566982A
Authority: DK; Denmark
Prior art keywords: sub; sup; nitrogen; medicine; procedures
Prior art date: 1981-12-23

Application number

DK566982A

Other languages

English (en)

Other versions

DK163240C (da

DK163240B (da

Inventor

Gregor Haffer

Gerhard Sauer

Helmut Wachtel

Herbert Schneider

Ulrich Eder

Hans-Peter Lorenz

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-23

Filing date

1982-12-22

Publication date

1983-06-24

1982-12-22 Application filed by Schering Ag filed Critical Schering Ag

1983-06-24 Publication of DK566982A publication Critical patent/DK566982A/da

1992-02-10 Publication of DK163240B publication Critical patent/DK163240B/da

1992-06-29 Application granted granted Critical

1992-06-29 Publication of DK163240C publication Critical patent/DK163240C/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK566982A 1981-12-23 1982-12-22 Analogifremgangsmaade til fremstilling af hidtil ukendte i 8-stilling nitrogensubstituerede ergolinylforbindelser og farmaceutisk acceptable salte heraf DK163240C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19813151912 DE3151912A1 (de)	1981-12-23	1981-12-23	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3151912		1981-12-23

Publications (3)

Publication Number	Publication Date
DK566982A true DK566982A (da)	1983-06-24
DK163240B DK163240B (da)	1992-02-10
DK163240C DK163240C (da)	1992-06-29

Family

ID=6150011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK566982A DK163240C (da)	1981-12-23	1982-12-22	Analogifremgangsmaade til fremstilling af hidtil ukendte i 8-stilling nitrogensubstituerede ergolinylforbindelser og farmaceutisk acceptable salte heraf

Country Status (18)

Country	Link
US (1)	US4826852A (da)
EP (2)	EP0185392A3 (da)
JP (1)	JPS58150593A (da)
AT (1)	ATE27458T1 (da)
AU (1)	AU570621B2 (da)
CA (1)	CA1319684C (da)
CS (1)	CS235098B2 (da)
DD (1)	DD208619A5 (da)
DE (2)	DE3151912A1 (da)
DK (1)	DK163240C (da)
ES (1)	ES8400115A1 (da)
GR (1)	GR78410B (da)
HU (1)	HU191623B (da)
IE (1)	IE56541B1 (da)
IL (1)	IL67545A (da)
RO (2)	RO87945A (da)
SU (1)	SU1313348A3 (da)
YU (1)	YU282382A (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8400333A (nl) *	1983-02-16	1984-09-17	Sandoz Ag	Moederkoornalkaloiden, hun bereiding en hun toepassing.
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
DE3413657A1 (de) *	1984-04-09	1985-10-17	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue ergoline
DE3413659A1 (de) *	1984-04-09	1985-10-17	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 2-substituierte ergolin-derivate
HU195810B (en) *	1984-12-24	1988-07-28	Sandoz Ag	Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
DE3528576A1 (de) *	1985-08-06	1987-02-19	Schering Ag	Verfahren zur herstellung von ergolin-thioharnstoffen
DE3528584A1 (de) *	1985-08-06	1987-02-19	Schering Ag	Neue 1-alkyl-ergolin-thioharnstoffderivate
DE3533672A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-substituierte ergolinderivate
DE3533675A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-brom-ergolinderivate
DE3535929A1 (de) *	1985-10-04	1987-04-09	Schering Ag	1,2-disubstituierte ergolinderivate
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US5229129A (en) *	1989-07-12	1993-07-20	Cygnus Therapeutic Systems	Transdermal administration of lisuride
US5252335A (en) *	1989-07-12	1993-10-12	Cygnus Therapeutic Systems	Transdermal administration of lisuride
GB0307377D0 (en) *	2003-03-31	2003-05-07	Merad Pharmaceuticals Ltd	Ergoline derivatives
US20060140820A1 (en)	2004-12-28	2006-06-29	Udo Mattern	Use of a container of an inorganic additive containing plastic material
CA2664427C (en) *	2006-10-04	2012-06-05	M & P Patent Aktiengesellschaft	Controlled release delivery system for nasal application of neurotransmitters
EP2083008A1 (en) *	2007-12-07	2009-07-29	Axxonis Pharma AG	Ergoline derivatives as selective radical scavengers for neurons
US20130040923A1 (en)	2011-05-13	2013-02-14	Trimel Pharmaceuticals Corporation	Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en)	2011-05-13	2017-09-12	Acerus Pharmaceuticals Srl	Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US20130045958A1 (en)	2011-05-13	2013-02-21	Trimel Pharmaceuticals Corporation	Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US11744838B2 (en)	2013-03-15	2023-09-05	Acerus Biopharma Inc.	Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2533698A (en) *		1950-12-12		Urethanes containing the lysergic
US2864822A (en) *	1956-10-22	1958-12-16	Lilly Co Eli	9-amino-7-methyl-belta10-ergolene and derivatives thereof
DE1212097B (de) *	1962-09-05	1966-03-10	Sdruzeni Podnikuu Pro Zdravotn	Verfahren zur Herstellung von N-[D-1, 6-Dimethylisoergolenyl-(8)]-N', N'-dialkylharnstoffen
FR1339406A (fr) *	1962-11-23	1963-10-04	Farmaceutici Italia	Procédé de préparation de nouveaux dérivés de 6-méthylergoline pi et de 1, 6-diméthylergoline pi
BR6915443D0 (pt) *	1969-07-18	1973-03-13	Farmaceutici Italia	Processo para a preparacao de derivados de ergolina
CH573936A5 (da) *	1971-08-05	1976-03-31	Spofa Vereinigte Pharma Werke
US4348392A (en) *	1974-07-19	1982-09-07	Sandoz Ltd.	8α-Substituted ergoline-I derivatives
GB1573621A (en) *	1976-01-02	1980-08-28	Sandoz Ltd	Acylated 6-methyl-8a-amino-ergoline i compounds
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
DE2656344A1 (de) *	1975-12-23	1977-07-07	Sandoz Ag	Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
DE3063869D1 (en) *	1979-06-13	1983-07-28	Schering Ag	(ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them
CH654838A5 (fr) *	1980-07-25	1986-03-14	Sandoz Ag	Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen.
DE3135305C2 (de) *	1981-09-03	1983-07-21	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen
GB2112382B (en) *	1981-11-06	1985-03-06	Erba Farmitalia	Ergoline derivatives
DE3533675A1 (de) *	1985-09-19	1987-03-26	Schering Ag	Neue 12- und 13-brom-ergolinderivate

1981
- 1981-12-23 DE DE19813151912 patent/DE3151912A1/de not_active Withdrawn
1982
- 1982-12-09 SU SU823519900A patent/SU1313348A3/ru active
- 1982-12-14 AU AU91468/82A patent/AU570621B2/en not_active Ceased
- 1982-12-15 DD DD82246012A patent/DD208619A5/de unknown
- 1982-12-20 YU YU02823/82A patent/YU282382A/xx unknown
- 1982-12-20 RO RO82113566A patent/RO87945A/ro unknown
- 1982-12-20 RO RO109398A patent/RO85270B/ro unknown
- 1982-12-22 GR GR70153A patent/GR78410B/el unknown
- 1982-12-22 CS CS829553A patent/CS235098B2/cs unknown
- 1982-12-22 ES ES518482A patent/ES8400115A1/es not_active Expired
- 1982-12-22 CA CA000418299A patent/CA1319684C/en not_active Expired - Fee Related
- 1982-12-22 HU HU824138A patent/HU191623B/hu not_active IP Right Cessation
- 1982-12-22 DK DK566982A patent/DK163240C/da not_active IP Right Cessation
- 1982-12-22 IL IL67545A patent/IL67545A/xx not_active IP Right Cessation
- 1982-12-22 IE IE3051/82A patent/IE56541B1/en not_active IP Right Cessation
- 1982-12-23 EP EP85116397A patent/EP0185392A3/en not_active Withdrawn
- 1982-12-23 EP EP82730152A patent/EP0082808B1/en not_active Expired
- 1982-12-23 JP JP57225123A patent/JPS58150593A/ja active Granted
- 1982-12-23 AT AT82730152T patent/ATE27458T1/de not_active IP Right Cessation
- 1982-12-23 DE DE8282730152T patent/DE3276433D1/de not_active Expired
1986
- 1986-06-26 US US06/878,762 patent/US4826852A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GR78410B (da)	1984-09-27
US4826852A (en)	1989-05-02
IE823051L (en)	1983-06-23
DD208619A5 (de)	1984-04-04
RO85270B (ro)	1984-10-30
IE56541B1 (en)	1991-08-28
CS235098B2 (en)	1985-04-16
DK163240C (da)	1992-06-29
RO87945A (ro)	1986-09-30
IL67545A0 (en)	1983-05-15
ES518482A0 (es)	1983-11-01
RO85270A (ro)	1984-09-29
JPS58150593A (ja)	1983-09-07
DE3151912A1 (de)	1983-06-30
EP0082808A1 (en)	1983-06-29
EP0185392A3 (en)	1987-05-13
AU9146882A (en)	1983-06-30
JPH0352463B2 (da)	1991-08-12
HU191623B (en)	1987-03-30
DE3276433D1 (en)	1987-07-02
CA1319684C (en)	1993-06-29
CS955382A2 (en)	1984-02-13
EP0185392A2 (en)	1986-06-25
IL67545A (en)	1986-09-30
EP0082808B1 (en)	1987-05-27
ATE27458T1 (de)	1987-06-15
YU282382A (en)	1986-12-31
SU1313348A3 (ru)	1987-05-23
DK163240B (da)	1992-02-10
AU570621B2 (en)	1988-03-24
ES8400115A1 (es)	1983-11-01

Legal Events

Date	Code	Title	Description
1996-08-19	PBP	Patent lapsed

Publication	Publication Date	Title
DE3276433D1 (en)	1987-07-02	Novel ergolinyl compounds nitrogen-substituted in the 8-position, their preparation, and use as medicinal agents
ZA857824B (en)	1986-05-28	Substituted propane-phosphonous acid compounds
DK249386D0 (da)	1986-05-28	Benzoyl-urinstofderivater, fremgangsmaade til fremstilling af saadanne forbindelser og anvendelse af disse som insecticider
ES8702371A1 (es)	1986-12-16	Un procedimiento para preparar nuevos derivados de 6-(4-fenilo sustituido -3(2h) piradazinona.
DK157785D0 (da)	1985-04-09	1,5-benzothiazepinderivater og fremgangsmaade til deres fremstilling
NO814424L (no)	1982-09-03	Fremgangsmaate for fremstilling av terapeutisk virksomme 5,5`-azobis-salisylsyreforbindelser.
DK9186A (da)	1986-07-11	1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carboxylsyrer, deres fremstilling og anvendelse
NO863504L (no)	1987-03-04	Fremgangsmaate til fremstilling av ikke-toksiske salter av 6-metyl-3,4-dihydro-1,2,3-oksatiazin-4-on-2,2-dioksyd.
DK597786D0 (da)	1986-12-12	Krystallinske salte af aryloxypropanolaminer og fremgangsmaade til fremstilling heraf
DK160271C (da)	1991-07-22	Analogifremgangsmaade til fremstilling af 5-halogenvinyl-uracil-derivater
NO882113L (no)	1988-11-28	Substituerte vinylcefalosporiner, fremgangsmaate til deresfremstilling, og deres anvendelse som legemiddel.
NO865004D0 (no)	1986-12-11	Nye 16,17-acetalsubstituerte pregnan-21-oinsyre-derivater og fremgangsmaate for deres fremstilling.
DK403782A (da)	1983-03-11	9,10-substituerede 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isoquinolin-4-oner, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK286984D0 (da)	1984-06-12	1-acetonyl-2-(phenylimino)-imidazolidinderivater, deres syreadditionssalte, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser
NO842514L (no)	1984-12-27	Fremgangsmaate for fremstilling av bicyklo(3,2,1)oktankarboksylsyre-derivater.
AR243159A1 (es)	1993-07-30	Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico o sus sales farmaceuticamente aceptables.
DE3268605D1 (en)	1986-02-27	3,7a-diazacyclohepta(j,k)fluorene derivatives, their preparation and therapeutical use
NO885811L (no)	1989-07-03	Fremgangsmaate for fremstilling av 2-amino-tetrahydroisokinolinderivater.
DK144787D0 (da)	1987-03-20	Pyrido (4,3-b) (1,6) naphthyridin-derivater, fremgangsmaader til deres fremstilling og deres avendelse som laegemidler
NZ195324A (en)	1983-02-15	2,3,5,6,11,11b-hexahydroimidazo(1',5':1,2)-or 1,2,3,4,6,7,12,12b-octahydropyrimido(1',6':1,2)pyrido(3,4-b)indole(1,3or 2,4)-diones