CU20070094A7 - SOLID ORAL DOSAGE FORMS CONTAINING A LOW ESTRADIOL DOSE - Google Patents

SOLID ORAL DOSAGE FORMS CONTAINING A LOW ESTRADIOL DOSE

Info

Publication number
CU20070094A7
CU20070094A7 CU20070094A CU20070094A CU20070094A7 CU 20070094 A7 CU20070094 A7 CU 20070094A7 CU 20070094 A CU20070094 A CU 20070094A CU 20070094 A CU20070094 A CU 20070094A CU 20070094 A7 CU20070094 A7 CU 20070094A7
Authority
CU
Cuba
Prior art keywords
dosage forms
estradiol
solid oral
oral dosage
forms containing
Prior art date
Application number
CU20070094A
Other languages
Spanish (es)
Inventor
Christian Zurth
Kristina Mueller
Torsten Wagner
Adrian Funke
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CU20070094A7 publication Critical patent/CU20070094A7/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a formas de dosificación oral sólidas que contienen una dosis muy baja de estradiol. Las formas de dosificación se formulan de modotal que se evita la degradación del estradiol y se minimiza el contenido de polivinilpirrolidona, al tiempo que aún se logra una disolución rápida similar a la del estradiol. Las formas de dosificación son útiles para prevenir o tratar una condición física provocada en una mujer por niveles endógenos insuficientes de estradiol.The present invention relates to solid oral dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a modular manner that prevents degradation of estradiol and minimizes the content of polyvinylpyrrolidone, while still achieving a rapid dissolution similar to that of estradiol. Dosage forms are useful for preventing or treating a physical condition caused in a woman by insufficient endogenous levels of estradiol.

CU20070094A 2004-11-02 2007-04-30 SOLID ORAL DOSAGE FORMS CONTAINING A LOW ESTRADIOL DOSE CU20070094A7 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04078014 2004-11-02

Publications (1)

Publication Number Publication Date
CU20070094A7 true CU20070094A7 (en) 2009-09-08

Family

ID=34928627

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070094A CU20070094A7 (en) 2004-11-02 2007-04-30 SOLID ORAL DOSAGE FORMS CONTAINING A LOW ESTRADIOL DOSE

Country Status (21)

Country Link
EP (1) EP1814526A2 (en)
JP (1) JP2008518895A (en)
KR (1) KR20070085558A (en)
CN (1) CN101094656A (en)
AR (1) AR053650A1 (en)
AU (1) AU2005300658A1 (en)
BR (1) BRPI0517940A (en)
CA (1) CA2585095A1 (en)
CR (1) CR9112A (en)
CU (1) CU20070094A7 (en)
EA (1) EA013262B1 (en)
GT (1) GT200500315A (en)
IL (1) IL182635A0 (en)
MX (1) MX2007005281A (en)
NO (1) NO20072704L (en)
PA (1) PA8651401A1 (en)
PE (1) PE20061126A1 (en)
TW (1) TW200621312A (en)
UY (1) UY29185A1 (en)
WO (1) WO2006048261A2 (en)
ZA (1) ZA200705012B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022053B2 (en) 2004-11-02 2011-09-20 Bayer Schering Pharma Aktiengesellschaft Oral solid dosage forms containing a low dose of estradiol
KR20080047957A (en) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 Pharmaceutical composition for the treatment and prevention of hypertension
DE102009007771B4 (en) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Buccal administration system containing 17α-estradiol
JP5852639B2 (en) 2010-04-15 2016-02-03 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Low dose solid oral dosage form for HRT
KR20130097073A (en) 2010-04-15 2013-09-02 바이엘 인텔렉쳐 프로퍼티 게엠베하 Very low-dosed solid oral dosage forms for hrt
CN112516149B (en) * 2020-07-21 2023-07-18 南方医科大学 Application of estradiol benzoate or its pharmaceutically acceptable salt in the preparation of anti-coronavirus medicine
JP2024000555A (en) * 2022-06-21 2024-01-09 東ソー株式会社 Method for producing estradiol measurement reagent under ultraviolet ray suppression

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125071C (en) * 1963-12-24
US4755386A (en) * 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5073374A (en) * 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
FR2739558B1 (en) * 1995-10-05 1997-11-28 Innothera Lab Sa UNITAL GALENIC FORM FOR LOCAL HORMONOTHERAPY OF VAGINAL DROUGHT
FR2754179B1 (en) * 1996-10-08 1998-12-24 Theramex NOVEL HORMONONAL COMPOSITION AND ITS USE
US6326366B1 (en) * 2000-08-22 2001-12-04 Protein Technologies International Hormone replacement therapy
AU2001295359A1 (en) * 2000-10-30 2002-05-15 University Of Zurich GnRH analogues for treatment of urinary incontinence
EP3747443A3 (en) * 2000-12-15 2021-03-03 Novo Nordisk Health Care AG Use of an oestrogen in the manufacture of a composition containing oestrogen for the treatment of atrophic vaginitis
FR2823976A1 (en) * 2001-04-25 2002-10-31 Theramex NOVEL HORMONAL COMPOSITION AND ITS USE
US20030018018A1 (en) * 2001-07-10 2003-01-23 Medical College Of Hampton Roads Ultra low dose oral contraceptives with sustained efficacy and induced amenorrhea
US6962908B2 (en) * 2001-12-21 2005-11-08 Warner Chilcott Company Inc. Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation
JP2004155779A (en) * 2002-10-16 2004-06-03 Taisho Pharmaceut Co Ltd Oral composition for prevention and treatment of menopause

Also Published As

Publication number Publication date
KR20070085558A (en) 2007-08-27
BRPI0517940A (en) 2008-10-21
TW200621312A (en) 2006-07-01
ZA200705012B (en) 2008-10-29
EP1814526A2 (en) 2007-08-08
WO2006048261A3 (en) 2006-09-21
WO2006048261A2 (en) 2006-05-11
GT200500315A (en) 2006-06-06
AR053650A1 (en) 2007-05-16
PA8651401A1 (en) 2006-12-07
CR9112A (en) 2007-11-23
AU2005300658A1 (en) 2006-05-11
EA200700979A1 (en) 2007-10-26
CA2585095A1 (en) 2006-05-11
JP2008518895A (en) 2008-06-05
CN101094656A (en) 2007-12-26
NO20072704L (en) 2007-05-29
EA013262B1 (en) 2010-04-30
MX2007005281A (en) 2008-03-11
UY29185A1 (en) 2006-05-31
IL182635A0 (en) 2007-07-24
PE20061126A1 (en) 2006-11-11

Similar Documents

Publication Publication Date Title
AR055095A1 (en) NEW MACROCICLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
AR068185A1 (en) COMPOSITIONS OF LAMOTRIGIN ORAL DISINTEGRATION TABLETS
AR054139A1 (en) MODIFIED FORMATION AND IMMEDIATE RELEASE OF MEMANTINE SPHERES
CR9662A (en) ACTIVE CANABINOID PHARMACEUTICAL INGREDIENT FOR IMPROVED DOSE FORMS
ECSP066959A (en) MACROCICLICAL COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION
ECSP066990A (en) FORMULATIONS WITH CONTROLLED RELEASE OF ACTIVE PRINCIPLE CONTAINING VARDENAFILO
BRPI0414428A (en) pharmaceutical compositions
CR9112A (en) SOLID ORAL DOSAGE FORMS CONTAINING A LOW ESTRADIOL DOSE
AR109263A2 (en) COMPOSITION INCLUDING MOXIDECTINE
ES2421731T3 (en) Composition and procedure for the treatment of MRSA
CU20090112A6 (en) MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION
ECSP066553A (en) MASTICABLE ADMINISTRATION FORMS, NOT INDIVIDUALLY DOSED COMPRESSED.
MX2023003401A (en) Pharmaceutical composition for preventing or treating cholestatic liver disease, containing î¿eta-lapachone as active ingredient.
DE602006016127D1 (en) COMPOSITION AND DOSAGE FORM WITH A SOLID OR HALF-RESISTANT MATRIX
PE20070333A1 (en) PHARMACEUTICAL COMPOSITION INCLUDING AGOMELATIN FOR THE TREATMENT OF SLEEP DISORDERS IN DEPRESSED PATIENTS
CR8574A (en) SILINAN COMPOUNDS AS INHIBITORS OF CISTEINE PROTEASA
PA8549401A1 (en) COMPLEX THAT INCLUDES INHIBITING FACTOR OF OSTEOCLASTOGENESIS AND POLISACARIDO
CR9074A (en) AGENT FOR THE PROPHYLAXIS OR TREATMENT OF METABOLIC SYNDROME
AR050572A1 (en) COMPOSITIONS GERMICIDES CONTAINING MIXTURES OF FTALALDEHYDES AND METHODS OF USE OF SUCH COMPOSITIONS FOR DISINFECTION OR STERILIZATION
SE0203817D0 (en) New composition
AR029718A1 (en) PHARMACEUTICAL COMPOSITION BASED ON COCAETHYLENE AND ITS USE FOR THE TREATMENT OF THE DEPENDENCY OF PSYCHOACTIVE SUBSTANCES
AR057161A1 (en) METHODS AND DOSAGE FORMS OF BENZISOXAZOL DERIVATIVES WITH BETTER EFFECTIVENESS
MX2025013233A (en) POLYMORPHIC FORMS AND FORMULATIONS OF LERIGLITAZONE
AR048355A1 (en) ASSOCIATION BETWEEN A HETEROCICLICAL COMPOUND AND AN ANTIOXIDANT AGENT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ATE493976T1 (en) PHARMACEUTICAL COMPOSITION CONTAINING BAKUCHIOL FOR THE TREATMENT OF FEMALE OSTEOPOROSIS