CU20070160A7 - Pirrolopirazoles, inhibidores potentes de quinasa - Google Patents

Pirrolopirazoles, inhibidores potentes de quinasa

Info

Publication number
CU20070160A7
CU20070160A7 CU20070160A CU20070160A CU20070160A7 CU 20070160 A7 CU20070160 A7 CU 20070160A7 CU 20070160 A CU20070160 A CU 20070160A CU 20070160 A CU20070160 A CU 20070160A CU 20070160 A7 CU20070160 A7 CU 20070160A7
Authority
CU
Cuba
Prior art keywords
pirrolopirazoles
powerful
inhibitors
quinasa
quinasa inhibitors
Prior art date
Application number
CU20070160A
Other languages
English (en)
Other versions
CU23778B7 (es
Inventor
Anle Yang
Junhu Zhang
Haitao Li
Chuangxing Guo
Liming Dong
Djamal Bouzida
Yufeng Hong
Joseph Timothy Marakovits
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20070160A7 publication Critical patent/CU20070160A7/es
Publication of CU23778B7 publication Critical patent/CU23778B7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Se proporcionan compuestos de pirrolo-pirazol de fórmula I, composiciones que incluyen estos compuestos y procedimientos de su uso. Los compuestos preferidos de fórmula I tienen actividad como inhibidores de proteína cinasa, incluyendo como inhibidores de PAK4.
CU20070160A 2005-01-10 2007-07-09 Pirrolopirazoles, inhibidores potentes de quinasa CU23778B7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64290005P 2005-01-10 2005-01-10
US73377005P 2005-11-04 2005-11-04

Publications (2)

Publication Number Publication Date
CU20070160A7 true CU20070160A7 (es) 2009-03-16
CU23778B7 CU23778B7 (es) 2012-02-15

Family

ID=36463340

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070160A CU23778B7 (es) 2005-01-10 2007-07-09 Pirrolopirazoles, inhibidores potentes de quinasa

Country Status (29)

Country Link
US (2) US8067591B2 (es)
EP (1) EP1838718B1 (es)
JP (1) JP4250195B2 (es)
KR (1) KR100919343B1 (es)
CN (1) CN101115760B (es)
AP (1) AP2007004061A0 (es)
AT (1) ATE512972T1 (es)
AU (1) AU2005323797B2 (es)
BR (1) BRPI0518509A2 (es)
CA (1) CA2593428C (es)
CU (1) CU23778B7 (es)
CY (1) CY1111752T1 (es)
DK (1) DK1838718T3 (es)
EA (1) EA011815B1 (es)
ES (1) ES2365245T3 (es)
GE (1) GEP20094785B (es)
HR (1) HRP20110485T1 (es)
IL (1) IL184275A0 (es)
MA (1) MA29141B1 (es)
MX (1) MX2007008385A (es)
NO (1) NO20073859L (es)
NZ (1) NZ556273A (es)
PL (1) PL1838718T3 (es)
PT (1) PT1838718E (es)
RS (1) RS51891B (es)
SI (1) SI1838718T1 (es)
TN (1) TNSN07254A1 (es)
WO (1) WO2006072831A1 (es)
ZA (1) ZA200705628B (es)

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EA017937B1 (ru) 2007-02-07 2013-04-30 Пфайзер Инк. ПРОИЗВОДНЫЕ 3-АМИНОПИРРОЛО[3,4-c]ПИРАЗОЛ-5(1H,4H,6H)-КАРБАЛЬДЕГИДА В КАЧЕСТВЕ ИНГИБИТОРОВ РКС
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WO2013113720A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
WO2013113791A1 (en) 2012-02-03 2013-08-08 Basf Se Fungicidal pyrimidine compounds
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IN2014DN07954A (es) 2012-03-13 2015-05-01 Basf Se
HK1200093A1 (en) 2012-03-16 2015-07-31 霍夫曼-拉罗奇有限公司 Methods of treating melanoma with pak1 inhibitors
CA2882410A1 (en) 2012-09-19 2014-03-27 Novartis Ag Dihydropyrrolidino-pyrimidines as kinase inhibitors
US9388167B2 (en) * 2012-10-15 2016-07-12 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogues thereof
CA2923101A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh) 2015-03-27 2021-08-03 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
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KR102736865B1 (ko) 2017-06-21 2024-12-03 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
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Also Published As

Publication number Publication date
CN101115760A (zh) 2008-01-30
MX2007008385A (es) 2007-08-21
GEP20094785B (en) 2009-09-25
WO2006072831A1 (en) 2006-07-13
HRP20110485T1 (hr) 2011-07-31
JP4250195B2 (ja) 2009-04-08
CN101115760B (zh) 2010-11-03
ES2365245T3 (es) 2011-09-27
US8067591B2 (en) 2011-11-29
EP1838718B1 (en) 2011-06-15
BRPI0518509A2 (pt) 2008-11-25
SI1838718T1 (sl) 2011-08-31
PT1838718E (pt) 2011-08-17
ATE512972T1 (de) 2011-07-15
NO20073859L (no) 2007-10-03
CA2593428A1 (en) 2006-07-13
AP2007004061A0 (en) 2007-08-31
AU2005323797B2 (en) 2009-07-09
CU23778B7 (es) 2012-02-15
TNSN07254A1 (en) 2008-12-31
ZA200705628B (en) 2008-11-26
KR20070096007A (ko) 2007-10-01
AU2005323797A1 (en) 2006-07-13
CA2593428C (en) 2012-04-17
HK1114380A1 (en) 2008-10-31
US20100222342A1 (en) 2010-09-02
EA200701257A1 (ru) 2007-12-28
IL184275A0 (en) 2007-10-31
NZ556273A (en) 2010-01-29
RS51891B (sr) 2012-02-29
DK1838718T3 (da) 2011-07-25
EA011815B1 (ru) 2009-06-30
US20120264751A1 (en) 2012-10-18
MA29141B1 (fr) 2008-01-02
EP1838718A1 (en) 2007-10-03
US8530652B2 (en) 2013-09-10
CY1111752T1 (el) 2015-10-07
JP2008526826A (ja) 2008-07-24
KR100919343B1 (ko) 2009-09-25
PL1838718T3 (pl) 2011-10-31

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