ATE512967T1 - Als kinaseinhibitoren geeignete pyrrolotriazinverbindungen - Google Patents

Als kinaseinhibitoren geeignete pyrrolotriazinverbindungen

Info

Publication number
ATE512967T1
ATE512967T1 AT06785986T AT06785986T ATE512967T1 AT E512967 T1 ATE512967 T1 AT E512967T1 AT 06785986 T AT06785986 T AT 06785986T AT 06785986 T AT06785986 T AT 06785986T AT E512967 T1 ATE512967 T1 AT E512967T1
Authority
AT
Austria
Prior art keywords
kinase inhibitors
compounds suitable
pyrrolotriazine compounds
pyrrolotriazine
pyrrolotriazine derivative
Prior art date
Application number
AT06785986T
Other languages
English (en)
Inventor
Ping Chen
Derek J Norris
Ashvinikumar V Gavai
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE512967T1 publication Critical patent/ATE512967T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06785986T 2005-07-01 2006-06-29 Als kinaseinhibitoren geeignete pyrrolotriazinverbindungen ATE512967T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69639005P 2005-07-01 2005-07-01
US69639405P 2005-07-01 2005-07-01
US70308605P 2005-07-28 2005-07-28
PCT/US2006/025632 WO2007005631A1 (en) 2005-07-01 2006-06-29 Pyrrolotriazine compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE512967T1 true ATE512967T1 (de) 2011-07-15

Family

ID=37146496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06785986T ATE512967T1 (de) 2005-07-01 2006-06-29 Als kinaseinhibitoren geeignete pyrrolotriazinverbindungen

Country Status (4)

Country Link
US (1) US7405213B2 (de)
EP (1) EP1899346B1 (de)
AT (1) ATE512967T1 (de)
WO (1) WO2007005631A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28931A1 (es) 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
WO2007041358A2 (en) * 2005-09-30 2007-04-12 Miikana Therapeutics, Inc. Substituted pyrazole compounds
KR101461680B1 (ko) * 2005-12-02 2014-11-19 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체
PE20070855A1 (es) * 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
AU2008262291A1 (en) * 2007-06-11 2008-12-18 Miikana Therapeutics, Inc. Substituted pyrazole compounds
MX2010003269A (es) * 2007-09-25 2010-08-02 Bayer Healthcare Llc Derivados de pirrolotriazina utiles para tratar cancer a traves de la inhibicion de la aurora quinasa.
EP2376491B1 (de) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazine als alk- und jak2-inhibitoren
CN103304489B (zh) * 2012-03-16 2015-03-11 中国农业科学院兰州畜牧与兽药研究所 嘧啶苯甲酰胺类化合物及其制备和应用
KR102792835B1 (ko) * 2019-11-18 2025-04-07 점보 드러그 뱅크 컴퍼니 리미티드 Mnk 억제제로서의 피롤로트리아진 화합물
CN119925378B (zh) * 2023-11-03 2026-04-10 成都嘉葆药银医药科技有限公司 吡咯并三嗪类化合物在制备预防和/或治疗纤维化或其相关疾病的药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303660B6 (cs) 1999-05-21 2013-02-13 Bristol-Myers Squibb Company Pyrrolotriazin a farmaceutický prostredek s jeho obsahem
US6982265B1 (en) 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6670357B2 (en) 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
KR100847605B1 (ko) 2000-11-17 2008-07-21 브리스톨-마이어스스퀴브컴파니 ｐ38 키나제 관련 질병의 치료 방법 및 키나제 억제제로서유용한 피롤로트리아진 화합물
EP1497019B1 (de) 2002-04-23 2015-05-20 Bristol-Myers Squibb Company Pyrrolo-triazin-anilin-verbindungen als kinaseinhibitoren
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
WO2004013145A1 (en) 2002-08-02 2004-02-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
US7102002B2 (en) 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors

Also Published As

Publication number Publication date
WO2007005631A1 (en) 2007-01-11
EP1899346B1 (de) 2011-06-15
US7405213B2 (en) 2008-07-29
US20070004733A1 (en) 2007-01-04
EP1899346A1 (de) 2008-03-19

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