CU20120014A7 - Preparación de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos - Google Patents

Preparación de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos

Info

Publication number
CU20120014A7
CU20120014A7 CU20120014A CU20120014A CU20120014A7 CU 20120014 A7 CU20120014 A7 CU 20120014A7 CU 20120014 A CU20120014 A CU 20120014A CU 20120014 A CU20120014 A CU 20120014A CU 20120014 A7 CU20120014 A7 CU 20120014A7
Authority
CU
Cuba
Prior art keywords
sulfonamide
difluoro
fluoro
preparation
iodofenilamino
Prior art date
Application number
CU20120014A
Other languages
English (en)
Other versions
CU24113B1 (es
Inventor
Andreas Maderna
Jean-Michel Vernier
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20120014(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of CU20120014A7 publication Critical patent/CU20120014A7/es
Publication of CU24113B1 publication Critical patent/CU24113B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se relaciona con la preparación de (R)-N-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (S)-N-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida.
CUP2012000014A 2009-07-24 2010-07-10 Preparación de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos CU24113B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850109P 2009-07-24 2009-07-24
US22850909P 2009-07-24 2009-07-24

Publications (2)

Publication Number Publication Date
CU20120014A7 true CU20120014A7 (es) 2012-06-21
CU24113B1 CU24113B1 (es) 2015-08-27

Family

ID=42830488

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2012000014A CU24113B1 (es) 2009-07-24 2010-07-10 Preparación de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos

Country Status (31)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN102471246B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2990097A1 (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158B1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
AU2012264884B2 (en) * 2011-05-27 2017-03-09 Bayer Intellectual Property Gmbh Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
CN104011039A (zh) * 2011-12-19 2014-08-27 住友化学株式会社 磺酸盐的制造方法
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1912636T1 (sl) * 2005-07-21 2014-08-29 Ardea Biosciences, Inc. N-(arilamino)-sulfonamidni inhibitorji MEK
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
US7842836B2 (en) 2006-04-11 2010-11-30 Ardea Biosciences N-aryl-N'alkyl sulfamides as MEK inhibitors
JP5269762B2 (ja) * 2006-04-18 2013-08-21 アーディア・バイオサイエンシーズ・インコーポレイテッド Ｍｅｋ阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド
CA2924436A1 (en) * 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use
MX2010011314A (es) * 2008-04-14 2010-11-12 Ardea Biosciences Inc Composiciones y metodos de preparacion y uso de las mismas.
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
CA2768788A1 (en) 2011-01-27
ECSP12011621A (es) 2012-02-29
KR20120032536A (ko) 2012-04-05
CL2012000192A1 (es) 2012-10-05
CN102471246A (zh) 2012-05-23
AU2010275780A1 (en) 2012-02-02
US20130261320A1 (en) 2013-10-03
WO2011009541A1 (en) 2011-01-27
TWI524890B (zh) 2016-03-11
US20120178946A1 (en) 2012-07-12
MX344965B (es) 2017-01-12
TN2012000027A1 (en) 2013-09-19
EA201200175A1 (ru) 2012-12-28
TW201113017A (en) 2011-04-16
NZ597738A (en) 2014-03-28
DOP2012000017A (es) 2012-05-15
MX2012001063A (es) 2012-03-26
BR112012001592A2 (pt) 2016-03-08
JP2013500242A (ja) 2013-01-07
MA33452B1 (fr) 2012-07-03
CU24113B1 (es) 2015-08-27
KR101763437B1 (ko) 2017-07-31
EP2462111A1 (en) 2012-06-13
AU2010275780B2 (en) 2015-10-22
HK1171218A1 (en) 2013-03-22
PE20120573A1 (es) 2012-05-17
EP2462111B1 (en) 2016-03-30
CN103848808B (zh) 2016-02-10
CA2990097A1 (en) 2011-01-27
MY160421A (en) 2017-03-15
PH12014500158A1 (en) 2015-09-07
IL217312A (en) 2017-02-28
US8884058B2 (en) 2014-11-11
CN103848808A (zh) 2014-06-11
CR20120044A (es) 2012-03-12
IN2012DN00696A (es) 2015-06-19
HK1198364A1 (zh) 2015-04-10
SG177535A1 (en) 2012-03-29
US20150274651A1 (en) 2015-10-01
US9296686B2 (en) 2016-03-29
CN102471246B (zh) 2015-08-26
US8513443B2 (en) 2013-08-20
CO6491075A2 (es) 2012-07-31
AR079183A1 (es) 2012-01-04
JP5776115B2 (ja) 2015-09-09
GT201200017A (es) 2013-12-19
IL217312A0 (en) 2012-02-29
HN2012000142A (es) 2015-06-08
PH12014500158B1 (en) 2015-09-07
CA2768788C (en) 2018-01-09
EA023623B1 (ru) 2016-06-30
UY32800A (es) 2011-01-31

Similar Documents

Publication Publication Date Title
MX388468B (es) Compuestos multicíclicos y métodos de uso de los mismos.
EA201270257A1 (ru) Производные n1-сульфонил-5-фторпиримидинона
EA201270254A1 (ru) Производные 5-фторпиримидинона
MX2013007104A (es) Derivados de biciclo[3,2,1]octilamida y sus usos.
CL2016000344A1 (es) Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
CR10955A (es) Nuevo procedimiento de sintesis de la agomelatina
CR10960A (es) Nuevo procedimiento de sintesis de la agomelatina
EA201270253A1 (ru) Производные n1-ацил-5-фторпиримидинона
AR074222A1 (es) Derivados lantibioticos carboxiamida con actividad antibacterial mejorada, procedimiento de obtencion sus composiciones farmaceuticas derivados carboxamida y empleo de los mismos
CR20120524A (es) Combinaciones que contienen 2,3-dihidroimidazo [1,2-c] quinazolina sustituida
MX372721B (es) Ánalogos halogenados de agentes antifi-broticos.
ECSP13012914A (es) Síntesis de derivados de 2-carboxamida-cicloamino-urea
ECSP12011621A (es) Preparación de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodo-fenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos
CR10934A (es) Nuevo procedimiento de sintesis de la agomelatina
CY1113338T1 (el) Νεα μεθοδος για συνθεση ιβαμπραδινης και αλατων προσθηκης αυτης
EA201201674A1 (ru) Способы разделения замещенных по атому азота производных (s)-5-алкокси-2-аминотетралина
ECSP10010292A (es) Nuevos derivados de ácido 2-mercaptociclopentanocarboxílico, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
UA106762C2 (uk) Спосіб одержання (r)- та (s)-n-(3,4-дифтор-2-(2-фтор-4-йодфеніламіно)-6-метоксифеніл)-1-(2,3-дигідроксипропіл)циклопропан-1-сульфанаміду та його захищених похідних
CO6700896A2 (es) Procesos para la preparación de enaminas
CR20130029A (es) Compuestos de tiofeno 2,3,5-trisustituidos y usos de los mismos
HN2008000082A (es) Derivados de n-(heteroaril)-1-heteroarilalquil-1h-indol-2-carboxamidas, su preparacion y aplicacion en terapeutica
UA91166C2 (en) use of ethyl ether N-[(2-oxoindolylinylydene-3)-2-oxyacetyl]-aminoacetic acid of the general formula as nootropic and anxyolytic agent
TH46117S1 (th) อุปกรณ์ถ่างกล้ามเนื้อสำหรับผ่าตัด

Legal Events

Date Code Title Description
FG Grant of patent