CL2012000192A1 - Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. - Google Patents

Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.

Info

Publication number
CL2012000192A1
CL2012000192A1 CL2012000192A CL2012000192A CL2012000192A1 CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1 CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1
Authority
CL
Chile
Prior art keywords
cyclopropan
sulfonamide
sulfonamides
diamine
obtaining
Prior art date
Application number
CL2012000192A
Other languages
English (en)
Inventor
Andreas Vernier Jean Michael Maderna
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000192(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of CL2012000192A1 publication Critical patent/CL2012000192A1/es
Priority to CL2015001030A priority Critical patent/CL2015001030A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Proceso para preparar (R) y (S)-N-(3,4-difluoro-2 (2-fluoro-4 yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y compuestos intermediarios.
CL2012000192A 2009-07-24 2012-01-24 Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. CL2012000192A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CL2015001030A CL2015001030A1 (es) 2009-07-24 2015-04-22 Proceso para preparar (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonamida y compuestos intermediarios (div. sol. 192-12).

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850109P 2009-07-24 2009-07-24
US22850909P 2009-07-24 2009-07-24

Publications (1)

Publication Number Publication Date
CL2012000192A1 true CL2012000192A1 (es) 2012-10-05

Family

ID=42830488

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000192A CL2012000192A1 (es) 2009-07-24 2012-01-24 Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.

Country Status (31)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN103848808B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2768788C (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158B1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
UA113850C2 (xx) 2011-05-27 2017-03-27 Хіральний синтез n-{3,4-дифтор-2-$(2-фтор-4-йодфеніл)аміно]-6-метоксифеніл}-1-$2,3-дигідроксипропіл]циклопропансульфонамідів
JPWO2013094546A1 (ja) * 2011-12-19 2015-04-27 住友化学株式会社 スルホン酸塩の製造方法
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
CN101495118B (zh) * 2005-07-21 2012-09-05 阿迪亚生命科学公司 Mek的n-(芳基氨基)磺酰胺抑制剂
WO2007121269A2 (en) * 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
ES2354182T3 (es) * 2006-04-18 2011-03-10 Ardea Biosciences, Inc. Piridona sulfonamidas y piridona sulfamidas como inhibidores de mek.
CA2924418A1 (en) * 2007-07-30 2009-02-05 Jean-Michel Vernier Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
US8808742B2 (en) * 2008-04-14 2014-08-19 Ardea Biosciences, Inc. Compositions and methods for preparing and using same
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
IL217312A0 (en) 2012-02-29
CA2990097A1 (en) 2011-01-27
CU20120014A7 (es) 2012-06-21
CN102471246A (zh) 2012-05-23
JP5776115B2 (ja) 2015-09-09
CR20120044A (es) 2012-03-12
CN102471246B (zh) 2015-08-26
US20120178946A1 (en) 2012-07-12
UY32800A (es) 2011-01-31
PH12014500158A1 (en) 2015-09-07
CA2768788C (en) 2018-01-09
HK1198364A1 (zh) 2015-04-10
MA33452B1 (fr) 2012-07-03
US8513443B2 (en) 2013-08-20
CU24113B1 (es) 2015-08-27
GT201200017A (es) 2013-12-19
US9296686B2 (en) 2016-03-29
TW201113017A (en) 2011-04-16
EA023623B1 (ru) 2016-06-30
HN2012000142A (es) 2015-06-08
EP2462111A1 (en) 2012-06-13
NZ597738A (en) 2014-03-28
AR079183A1 (es) 2012-01-04
AU2010275780A1 (en) 2012-02-02
SG177535A1 (en) 2012-03-29
WO2011009541A1 (en) 2011-01-27
HK1171218A1 (en) 2013-03-22
IN2012DN00696A (es) 2015-06-19
ECSP12011621A (es) 2012-02-29
CO6491075A2 (es) 2012-07-31
US8884058B2 (en) 2014-11-11
MY160421A (en) 2017-03-15
AU2010275780B2 (en) 2015-10-22
CN103848808B (zh) 2016-02-10
PH12014500158B1 (en) 2015-09-07
TWI524890B (zh) 2016-03-11
PE20120573A1 (es) 2012-05-17
MX344965B (es) 2017-01-12
MX2012001063A (es) 2012-03-26
EA201200175A1 (ru) 2012-12-28
CA2768788A1 (en) 2011-01-27
DOP2012000017A (es) 2012-05-15
CN103848808A (zh) 2014-06-11
BR112012001592A2 (pt) 2016-03-08
US20130261320A1 (en) 2013-10-03
EP2462111B1 (en) 2016-03-30
KR20120032536A (ko) 2012-04-05
US20150274651A1 (en) 2015-10-01
JP2013500242A (ja) 2013-01-07
KR101763437B1 (ko) 2017-07-31
TN2012000027A1 (en) 2013-09-19
IL217312A (en) 2017-02-28

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