CU20160160A7 - Compuestos derivados de metoxibencil-pirrolopirimidin-amina como agonistas del receptor tipo toll 7 (tlr7) - Google Patents

Compuestos derivados de metoxibencil-pirrolopirimidin-amina como agonistas del receptor tipo toll 7 (tlr7)

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Publication number
CU20160160A7
CU20160160A7 CUP2016000160A CU20160160A CU20160160A7 CU 20160160 A7 CU20160160 A7 CU 20160160A7 CU P2016000160 A CUP2016000160 A CU P2016000160A CU 20160160 A CU20160160 A CU 20160160A CU 20160160 A7 CU20160160 A7 CU 20160160A7
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Cuba
Prior art keywords
hepatitis
tlr7
toll
cancer
compounds derived
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CUP2016000160A
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English (en)
Other versions
CU24401B1 (es
Inventor
Yongkai Li
Tingting Mo
Porino Va
Tom Yao-Hsiang Wu
Xiaoyue Zhang
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53284501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20160160(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20160160A7 publication Critical patent/CU20160160A7/es
Publication of CU24401B1 publication Critical patent/CU24401B1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P31/12—Antivirals
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona compuestos derivados de metoxibencil-pirrolopirimidin-amina de fórmula (I) o una sal farmacéuticamente aceptable del mismo; activos como agonistas del receptor tipo Toll 7 (TLR7); ESPACIO PARA LA FÓRMULA Un método para la elaboración de los compuestos de la invención. Tales compuestos tratan enfermedades o condiciones como asma, enfermedad pulmonar obstructiva crónica (COPD), síndrome de insuficiencia respiratoria de adultos (ARDS), colitis ulcerativa, enfermedad de Crohn, bronquitis, dermatitis, queratosis actínica, carcinoma de células basales, cáncer de vejiga, rinitis alérgica, soriasis, esclerodermia, urticaria, artritis reumatoide, esclerosis múltiple, cáncer, cáncer de mama, VIH, hepatitis, hepatitis C, lupus, hepatitis B, cáncer colo-rectal o carcinoma hepatocelular.
CU2016000160A 2014-05-01 2015-04-29 Compuestos derivados de metoxibencil-pirrolopirimidin-amina como agonistas del receptor tipo toll 7 (tlr7) CU24401B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461987321P 2014-05-01 2014-05-01
PCT/US2015/028264 WO2015168269A1 (en) 2014-05-01 2015-04-29 Compounds and compositions as toll-like receptor 7 agonists

Publications (2)

Publication Number Publication Date
CU20160160A7 true CU20160160A7 (es) 2017-04-05
CU24401B1 CU24401B1 (es) 2019-05-03

Family

ID=53284501

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2016000160A CU24401B1 (es) 2014-05-01 2015-04-29 Compuestos derivados de metoxibencil-pirrolopirimidin-amina como agonistas del receptor tipo toll 7 (tlr7)

Country Status (30)

Country Link
US (1) US9902730B2 (es)
EP (1) EP3137470B1 (es)
JP (1) JP6484253B2 (es)
KR (1) KR102139847B1 (es)
CN (1) CN106232603B (es)
AP (1) AP2016009485A0 (es)
AR (1) AR100244A1 (es)
AU (1) AU2015253215B2 (es)
BR (1) BR112016025423A2 (es)
CA (1) CA2946408C (es)
CL (1) CL2016002751A1 (es)
CR (1) CR20160512A (es)
CU (1) CU24401B1 (es)
DO (1) DOP2016000295A (es)
EA (1) EA030603B1 (es)
ES (1) ES2877050T3 (es)
GT (1) GT201600233A (es)
IL (1) IL248347B (es)
MX (1) MX362341B (es)
NI (1) NI201600164A (es)
NZ (1) NZ724792A (es)
PE (1) PE20170325A1 (es)
PH (1) PH12016501966B1 (es)
PL (1) PL3137470T3 (es)
PT (1) PT3137470T (es)
SG (1) SG11201608161VA (es)
SV (1) SV2016005311A (es)
TW (1) TWI666212B (es)
UY (1) UY36103A (es)
WO (1) WO2015168269A1 (es)

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