CR20200037A - Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp - Google Patents

Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp

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Publication number
CR20200037A
CR20200037A CR20200037A CR20200037A CR20200037A CR 20200037 A CR20200037 A CR 20200037A CR 20200037 A CR20200037 A CR 20200037A CR 20200037 A CR20200037 A CR 20200037A CR 20200037 A CR20200037 A CR 20200037A
Authority
CR
Costa Rica
Prior art keywords
disease
compounds
formula
acute
kidney injury
Prior art date
Application number
CR20200037A
Other languages
English (en)
Inventor
William Roush
Shomir Ghosh
Dong-Ming Shen
Hans Martin Seidel
Shankar Venkatraman
David Guenther Winkler
Jr Anthony William Opipari
Gary Glick
Jason Katz
Luigi Franchi
Original Assignee
Novartis Inflammasome Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Inflammasome Res Inc filed Critical Novartis Inflammasome Res Inc
Publication of CR20200037A publication Critical patent/CR20200037A/es

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

En un aspecto, se proveen compuestos de la Fórmula AA, o una sal farmacéuticamente aceptable de los mismos. Las variables indicadas en la Fórmula AA están definidas en las reivindicaciones. Los compuestos de la Fórmula AA son moduladores de la actividad de NLPR3 y, como tales, pueden ser usados en el tratamiento de trastornos metabólicos (por ejemplo, diabetes tipo 2, aterosclerosis, obesidad y gota), una enfermedad del sistema nervioso central (por ejemplo, enfermedad de Alzheimer, esclerosis múltiple, esclerosis lateral amiotrófica o enfermedad de Parkinson), enfermedad pulmonar (por ejemplo, asma, EPOC o fibrosis idiopática pulmonar), enfermedad hepática (por ejemplo, síndrome de NASH, hepatitis viral o cirrosis), enfermedad pancreática (por ejemplo, pancreatitis aguda y crónica), enfermedad renal (por ejemplo, lesión renal aguda o lesión renal crónica), enfermedad intestinal (por ejemplo, enfermedad de Crohn o colitis ulcerosa), enfermedad de la piel (por ejemplo, psoriasis), enfermedad musculoesquelética (por ejemplo, esclerodermia), un trastorno de los vasos (por ejemplo, arteritis de células gigantes), un trastorno de los huesos (por ejemplo, osteoartritis, osteoporosis o trastornos de osteopetrosis), enfermedad ocular (por ejemplo, glaucoma o degeneración macular), una enfermedad causada por infección viral (por ejemplo, VIH o SIDA), una enfermedad autoinmune (por ejemplo, artritis reumatoide, lupus eritematoso sistémico o tiroiditis autoinmune), cáncer o envejecimiento.
CR20200037A 2017-07-24 2018-07-23 Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp CR20200037A (es)

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Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11236045B2 (en) 2017-06-09 2022-02-01 Cadila Healthcare Limited Substituted sulfoximine compounds
HUE066566T2 (hu) 2017-07-24 2024-08-28 Novartis Ag Vegyületek és készítmények NLRP aktivitással összefüggõ állapotok kezelésére
TW201910316A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
AU2018350980C1 (en) 2017-10-18 2024-12-12 Incyte Corporation Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-y gamma inhibitors
PE20210050A1 (es) 2017-11-09 2021-01-08 Inflazome Ltd Nuevos compuestos de sulfonamida carboxamida
EP3707137A1 (en) 2017-11-09 2020-09-16 Inflazome Limited Novel sulfonamide carboxamide compounds
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
WO2019166619A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
CA3103664A1 (en) * 2018-07-03 2020-01-09 Novartis Ag Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist
BR112021001044A2 (pt) * 2018-07-20 2021-04-13 F. Hoffmann-La Roche Ag Compostos de sulfonimidamida como inibidores da atividade de interleucina-1
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
CN112672995A (zh) 2018-08-15 2021-04-16 英夫拉索姆有限公司 新型磺酰胺脲化合物
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
ES2957692T3 (es) 2018-11-13 2024-01-24 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP
ES2974842T3 (es) 2018-11-13 2024-07-01 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de nlrp
PL3880660T3 (pl) * 2018-11-13 2025-11-12 Novartis Ag Związki i kompozycje do leczenia stanów związanych z aktywnością nlrp
US20230051589A1 (en) * 2018-11-16 2023-02-16 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
FI3911631T3 (fi) 2019-01-14 2025-02-03 Zydus Lifesciences Ltd Uusia substituoituja sulfonyyliureajohdannaisia
US20230063462A1 (en) * 2019-01-23 2023-03-02 Novartis Ag Sulfonimidamide compounds and compositions for treating conditions associated with nlrp activity
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
GB201908219D0 (en) 2019-06-10 2019-07-24 Axalbion Sa Therapeutic use of a compound
SI3983387T1 (sl) 2019-06-12 2024-09-30 NodThera Limited Derivati sulfoniluree in njihove uporabe
ES3056339T3 (en) 2019-06-12 2026-02-19 Nodthera Ltd Sulfonylurea derivatives and uses thereof
EP3986879B1 (en) 2019-06-21 2024-10-02 AC Immune SA Fused 1,2-thiazoles and 1,2-thiazines which act as nlrp3 modulators
WO2021002887A1 (en) 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Gut-targeted nlrp3 antagonists and their use in therapy
CN110590576A (zh) * 2019-08-15 2019-12-20 安徽金禾实业股份有限公司 一种4-多氟代甲氧基邻苯二胺的制备方法
TW202115095A (zh) 2019-08-16 2021-04-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
EP4013761A1 (en) 2019-08-16 2022-06-22 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤
CA3158123A1 (en) * 2019-11-12 2021-05-20 Yonggang Wei Amide derivative and preparation method therefore and use thereof in medicine
KR102333562B1 (ko) * 2019-12-03 2021-12-01 전남대학교 산학협력단 Nlrp3 인플라마좀 억제제를 포함하는 노인성 치주질환 예방, 개선 또는 치료용 조성물 및 그의 방법
JP7843705B2 (ja) * 2020-01-22 2026-04-10 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｎｌｒｐ３モジュレーターとしてのスルホンイミドアミド化合物
US20230121952A1 (en) 2020-02-18 2023-04-20 Inflazome Limited Compounds
JP7504234B2 (ja) * 2020-06-11 2024-06-21 シーセン ファーマシューティカル カンパニー リミテッド ジメチルスルホキシミン誘導体
IL299084A (en) 2020-06-19 2023-02-01 Ac Immune Sa History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
IL301055A (en) 2020-09-04 2023-05-01 Nodthera Ltd Sulphamoyl urea derivatives containing alkyl-oxacycloalkyl moiety and uses thereof
KR102409344B1 (ko) * 2020-09-22 2022-06-15 가톨릭대학교 산학협력단 Nlrp3 인플라마좀 억제제 및 이의 용도
KR102409345B1 (ko) * 2020-09-22 2022-06-16 가톨릭대학교 산학협력단 Nlrp3 인플라마좀 억제제 및 이의 용도
CN116323598B (zh) 2020-11-20 2024-11-15 江苏恒瑞医药股份有限公司 三嗪二酮类衍生物、其制备方法及其在医药上的应用
CN116507608A (zh) * 2020-11-20 2023-07-28 戴纳立制药公司 化合物、组合物和方法
CN113061111A (zh) * 2021-03-16 2021-07-02 无锡海伦生物科技有限公司 具有光交联活性的氨基酸类化合物的制备方法
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
CN116917282A (zh) * 2021-05-10 2023-10-20 成都百裕制药股份有限公司 酰胺衍生物及其应用
CN116635374B (zh) * 2021-05-10 2025-05-06 康百达（四川）生物医药科技有限公司 酰胺衍生物及其应用
TW202246230A (zh) * 2021-05-10 2022-12-01 大陸商成都百裕製藥股份有限公司 醯胺衍生物及其應用
CN115616216B (zh) * 2021-07-15 2025-08-12 华南理工大学 抑制或阻断faah与nlrp3之间相互作用的制剂的用途
US20250082611A1 (en) 2021-07-23 2025-03-13 Novartis Ag Dosing regimen for an nlrp3 inhibitor in the treatment of osteoarthritis
WO2023098613A1 (zh) * 2021-12-03 2023-06-08 南京明德新药研发有限公司 二甲基亚磺酰亚胺衍生物的制备方法
WO2023098612A1 (zh) * 2021-12-03 2023-06-08 南京明德新药研发有限公司 二甲基亚磺酰亚胺衍生物的盐型及晶型
US20250109126A1 (en) 2021-12-22 2025-04-03 Ac Immune Sa Dihydro-oxazol derivative compounds
CN114436851B (zh) * 2022-01-17 2023-08-22 常州大学 一种n,n-二甲基苄胺及其衍生物的制备方法
CN114989058B (zh) * 2022-06-02 2024-04-16 中国科学院成都生物研究所 一种手性氯代砜亚胺类化合物及其衍生物的制备方法
EP4554945A1 (en) 2022-07-14 2025-05-21 AC Immune SA Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
CN115227712A (zh) * 2022-07-26 2022-10-25 上海市第五人民医院 NaHS在制备治疗骨质疏松药物中的应用
JP2025527188A (ja) 2022-07-27 2025-08-20 ノバルティス アーゲー Ｎｌｒｐ３阻害剤の投与計画
CA3261365A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa NEW COMPOUNDS
EP4719599A1 (en) 2023-06-02 2026-04-08 Merck Sharp & Dohme LLC 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3
WO2025068958A1 (en) 2023-09-29 2025-04-03 Novartis Ag Nlrp3 inhibitor for use in lowering the risk of cardiovascular diseases
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025153624A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025153625A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
WO2026057747A1 (en) 2024-09-11 2026-03-19 Ac Immune Sa Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666506A (en) 1984-08-08 1987-05-19 E. I. Du Pont De Nemours And Company Herbicidal pyrimidines
IL104088A0 (en) * 1991-12-20 1993-05-13 Lilly Co Eli Sulfonimidamides
US5258406A (en) 1991-12-20 1993-11-02 Eli Lilly And Company Sulfonimidamides
US5169860A (en) 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
JP3573757B2 (ja) 1997-01-29 2004-10-06 ファイザー・インク スルホニルウレア誘導体、およびインターロイキン−１の活性を制御する上でのスルホニルウレア誘導体の使用
EP1214087A1 (en) 1999-09-14 2002-06-19 Pfizer Products Inc. Combination treatment with il-1ra and compounds that inhibit il-1 processing and release
US6906063B2 (en) 2000-02-04 2005-06-14 Portola Pharmaceuticals, Inc. Platelet ADP receptor inhibitors
CA2369967A1 (en) 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
BRPI1006380B1 (pt) 2009-04-16 2021-04-06 Koninklijke Philips N.V. Método para comunicação em uma rede de uma primeira estação a uma segunda estação e estação de rádio
EP2927214B1 (en) 2012-11-30 2018-03-21 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
HUE055755T2 (hu) * 2015-02-16 2021-12-28 Univ Queensland Szulfonolkarmabidok és rokon vegyületeik valamint felhasználásuk
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2017184604A1 (en) 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
US11339136B2 (en) * 2016-04-18 2022-05-24 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
BR112018071347A2 (pt) 2016-04-19 2019-02-05 Innate Tumor Immunity Inc moduladores de nlrp3
CA3047336A1 (en) 2017-01-23 2018-07-26 Jecure Therapeutics, Inc. Chemical compounds as inhibitors of interleukin-1 activity
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
US11236045B2 (en) * 2017-06-09 2022-02-01 Cadila Healthcare Limited Substituted sulfoximine compounds
KR102669722B1 (ko) 2017-07-07 2024-05-29 인플라좀 리미티드 신규한 설폰아마이드 카복스아마이드 화합물
EP3658538B1 (en) 2017-07-24 2023-04-19 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
HUE066566T2 (hu) 2017-07-24 2024-08-28 Novartis Ag Vegyületek és készítmények NLRP aktivitással összefüggõ állapotok kezelésére
EP3668840A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
BR112021001044A2 (pt) 2018-07-20 2021-04-13 F. Hoffmann-La Roche Ag Compostos de sulfonimidamida como inibidores da atividade de interleucina-1
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
JP2022500412A (ja) 2018-09-13 2022-01-04 バイエル・アクチエンゲゼルシヤフト 害虫防除剤としての複素環誘導体
BR112021013936A2 (pt) 2019-01-18 2021-09-21 Nuvation Bio Inc. Compostos heterocíclicos como antagonistas de adenosina

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