CU20170018A7 - Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo - Google Patents

Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo

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Publication number
CU20170018A7
CU20170018A7 CUP2017000018A CU20170018A CU20170018A7 CU 20170018 A7 CU20170018 A7 CU 20170018A7 CU P2017000018 A CUP2017000018 A CU P2017000018A CU 20170018 A CU20170018 A CU 20170018A CU 20170018 A7 CU20170018 A7 CU 20170018A7
Authority
CU
Cuba
Prior art keywords
methyl
pirrolopiridine
trifluorometilo
rorc2
modulators
Prior art date
Application number
CUP2017000018A
Other languages
English (en)
Other versions
CU24407B1 (es
Inventor
Andrew Christopher Flick
Peter Jones
Neelu Kaila
Scot Richard Mente
Mark Edward Schnute
John David Trzupek
Michael L Vazquez
Göran Mattias Wennerstål
Li Xing
Edouard Zamaratski
Liying Zhang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20170018A7 publication Critical patent/CU20170018A7/es
Publication of CU24407B1 publication Critical patent/CU24407B1/es

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K7/00—Watering equipment for stock or game
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

<p>La presente invención proporciona pirrolopiridinas sustituidas con metilo y trifluorometilo,</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>y sus composiciones farmacéuticas, útiles en el tratamiento de enfermedades inflamatorias y trastornos del sistema inmunitario.</p>
CU2017000018A 2014-09-26 2015-09-22 Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo CU24407B1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462055811P 2014-09-26 2014-09-26
US201562110048P 2015-01-30 2015-01-30
US201562209124P 2015-08-24 2015-08-24
PCT/IB2015/057314 WO2016046755A1 (en) 2014-09-26 2015-09-22 Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof

Publications (2)

Publication Number Publication Date
CU20170018A7 true CU20170018A7 (es) 2017-07-04
CU24407B1 CU24407B1 (es) 2019-05-03

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CU2017000018A CU24407B1 (es) 2014-09-26 2015-09-22 Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo

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US (5) US9670201B2 (es)
EP (1) EP3197882A1 (es)
JP (1) JP6224870B2 (es)
KR (1) KR101933328B1 (es)
CN (1) CN106715416B (es)
AP (1) AP2017009800A0 (es)
AU (2) AU2015323380B2 (es)
BR (2) BR122017023934A2 (es)
CA (1) CA2905407A1 (es)
CL (1) CL2017000716A1 (es)
CO (1) CO2017002427A2 (es)
CR (1) CR20170108A (es)
CU (1) CU24407B1 (es)
DO (1) DOP2017000087A (es)
EA (1) EA030635B1 (es)
GE (2) GEAP201814455A (es)
GT (1) GT201700063A (es)
IL (1) IL250675A0 (es)
MA (1) MA40759A (es)
MD (1) MD20170027A2 (es)
MX (1) MX2017003956A (es)
NI (1) NI201700031A (es)
NZ (1) NZ729252A (es)
PE (1) PE20170703A1 (es)
PH (1) PH12017500494A1 (es)
SG (1) SG11201701329QA (es)
SV (1) SV2017005395A (es)
TN (1) TN2017000074A1 (es)
TW (1) TWI583685B (es)
UA (1) UA119569C2 (es)
UY (1) UY36322A (es)
WO (1) WO2016046755A1 (es)
ZA (2) ZA201701292B (es)

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MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
US10385036B2 (en) 2015-01-30 2019-08-20 Pfizer Inc. Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof
EP3250570A1 (en) 2015-01-30 2017-12-06 Pfizer Inc Methoxy-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof
TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
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EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド
CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
KR20200094493A (ko) 2019-01-30 2020-08-07 김남형 음성사후분포그램추출기와 tts 및 보코더를 이용한 음성 변조 어플리케이션의 동작방법
US12559496B2 (en) 2020-04-30 2026-02-24 Janssen Pharmaceutica Nv Imidazopyrimidines as modulators of IL-17
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WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19
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