CU20180109A7 - Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos - Google Patents

Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos

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Publication number
CU20180109A7
CU20180109A7 CU2018000109A CU20180109A CU20180109A7 CU 20180109 A7 CU20180109 A7 CU 20180109A7 CU 2018000109 A CU2018000109 A CU 2018000109A CU 20180109 A CU20180109 A CU 20180109A CU 20180109 A7 CU20180109 A7 CU 20180109A7
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CU
Cuba
Prior art keywords
methods
lymphocytes
car
cells
translate
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CU2018000109A
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English (en)
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CU24649B1 (es
Inventor
Gregory Ian Frost
Ghiabe H Guibinga
Anirban Kundu
James Joseph Onuffer
Original Assignee
F1 Oncology Inc
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Publication date
Application filed by F1 Oncology Inc filed Critical F1 Oncology Inc
Publication of CU20180109A7 publication Critical patent/CU20180109A7/es
Publication of CU24649B1 publication Critical patent/CU24649B1/es

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Abstract

<p>La presente invención se refiere a métodos para modificar linfocitos genéticamente y métodos para realizar terapia celular adoptiva que incluyen transducir células T y/o células NK sin estimulación ex vivo previa. Los métodos típicamente incluyen polipéptidos de señalización diseñados por ingeniería genética que pueden incluir un elemento linfoproliferativo, y/o un receptor de antígeno quimérico (CAR), por ejemplo un CAR de microambiente restringido. Elementos adicionales de tales polipéptidos de señalización diseñados por ingeniería genética se proporcionan en Ia presente, así como también vectores, tales como vectores retrovirales, líneas de células de empaquetamiento y métodos para elaborar los mismos. Además, se proporcionan retrovirus recombinante y métodos para<br /> elaborar los mismos. Se proporcionan numerosos controles, que incluyen los riboswitch o riboconmutadores que son controlados, por ejemplo in vivo, por análogos de nucleósido.</p>
CU2018000109A 2016-03-19 2017-03-19 Retrovirus recombinantes incompetentes de replicación para la transducción de linfocitos y expansión regulada de los mismos CU24649B1 (es)

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