CU20210038A7 - Compuestos derivados sustituidos de 6,7-dihidro- 4h-pirazolo pirazinindol-2' carboxamidas activas contra el virus de la hepatitis b (vhb) - Google Patents

Compuestos derivados sustituidos de 6,7-dihidro- 4h-pirazolo pirazinindol-2' carboxamidas activas contra el virus de la hepatitis b (vhb)

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Publication number
CU20210038A7
CU20210038A7 CU2021000038A CU20210038A CU20210038A7 CU 20210038 A7 CU20210038 A7 CU 20210038A7 CU 2021000038 A CU2021000038 A CU 2021000038A CU 20210038 A CU20210038 A CU 20210038A CU 20210038 A7 CU20210038 A7 CU 20210038A7
Authority
CU
Cuba
Prior art keywords
hbv
virus
pyrazinindol
pyrazole
dihydro
Prior art date
Application number
CU2021000038A
Other languages
English (en)
Inventor
Susanne Bonsmann
Alastair Donald
Jasper Springer
Andreas Urban
Anita Wegert
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of CU20210038A7 publication Critical patent/CU20210038A7/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<p>La presente invención se refiere a compuestos de la fórmula general I:</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>, útiles para inhibir la proteína o proteínas codificada (s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB. </p> <p>Se refiere también a las composiciones que comprenden estos compuestos y al método de preparación de los mismos.</p> <p> </p>
CU2021000038A 2018-11-02 2019-11-01 Compuestos derivados sustituidos de 6,7-dihidro- 4h-pirazolo pirazinindol-2' carboxamidas activas contra el virus de la hepatitis b (vhb) CU20210038A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18000876 2018-11-02
PCT/EP2019/079965 WO2020089453A1 (en) 2018-11-02 2019-11-01 Novel 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine indole-2-carboxamides active against the hepatitis b virus (hbv)

Publications (1)

Publication Number Publication Date
CU20210038A7 true CU20210038A7 (es) 2021-12-08

Family

ID=64362286

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2021000038A CU20210038A7 (es) 2018-11-02 2019-11-01 Compuestos derivados sustituidos de 6,7-dihidro- 4h-pirazolo pirazinindol-2' carboxamidas activas contra el virus de la hepatitis b (vhb)

Country Status (21)

Country Link
US (1) US20220363686A1 (es)
EP (1) EP3873909A1 (es)
JP (1) JP2022512871A (es)
KR (1) KR20210099562A (es)
CN (1) CN113056467A (es)
AR (1) AR116947A1 (es)
AU (1) AU2019370994A1 (es)
BR (1) BR112021008361A2 (es)
CA (1) CA3118380A1 (es)
CL (1) CL2021001117A1 (es)
CU (1) CU20210038A7 (es)
EA (1) EA202191216A1 (es)
EC (1) ECSP21031085A (es)
IL (1) IL282480A (es)
MX (1) MX2021004986A (es)
PH (1) PH12021550979A1 (es)
PY (1) PY1991603A (es)
SG (1) SG11202104130SA (es)
TW (1) TW202031661A (es)
UY (1) UY38436A (es)
WO (1) WO2020089453A1 (es)

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Also Published As

Publication number Publication date
CL2021001117A1 (es) 2021-11-05
PY1991603A (es) 2020-09-17
ECSP21031085A (es) 2021-05-31
TW202031661A (zh) 2020-09-01
BR112021008361A2 (pt) 2021-08-03
SG11202104130SA (en) 2021-05-28
IL282480A (en) 2021-06-30
UY38436A (es) 2020-05-29
KR20210099562A (ko) 2021-08-12
CA3118380A1 (en) 2020-05-07
EA202191216A1 (ru) 2021-08-03
EP3873909A1 (en) 2021-09-08
MX2021004986A (es) 2021-06-15
AU2019370994A1 (en) 2021-05-27
WO2020089453A1 (en) 2020-05-07
JP2022512871A (ja) 2022-02-07
CN113056467A (zh) 2021-06-29
PH12021550979A1 (en) 2021-11-22
US20220363686A1 (en) 2022-11-17
AR116947A1 (es) 2021-06-30

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