CU22584A1 - Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis - Google Patents

Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis

Info

Publication number
CU22584A1
CU22584A1 CU1995120A CU1995120A CU22584A1 CU 22584 A1 CU22584 A1 CU 22584A1 CU 1995120 A CU1995120 A CU 1995120A CU 1995120 A CU1995120 A CU 1995120A CU 22584 A1 CU22584 A1 CU 22584A1
Authority
CU
Cuba
Prior art keywords
pharmaceutical compositions
monoclonal antibody
recognizes
psoriasis
compositions containing
Prior art date
Application number
CU1995120A
Other languages
English (en)
Inventor
Blazquez Patricia Sierra
Valladares Josefa Lombardero
Casimiro Jose Enrique Montero
Bravo Blanca Rosa Tormo
Rodriguez Rolando Perez
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Priority to CU1995120A priority Critical patent/CU22584A1/es
Priority to CA002210751A priority patent/CA2210751C/en
Priority to PCT/CU1996/000004 priority patent/WO1997019111A2/es
Priority to AU76905/96A priority patent/AU722882B2/en
Priority to EP96939805A priority patent/EP0807125B1/en
Priority to ES96939805T priority patent/ES2231826T3/es
Priority to CNB96192098XA priority patent/CN1222540C/zh
Priority to DE69633717T priority patent/DE69633717T2/de
Priority to AT96939805T priority patent/ATE280783T1/de
Priority to BRPI9607171A priority patent/BRPI9607171B1/pt
Priority to PT96939805T priority patent/PT807125E/pt
Priority to DK96939805T priority patent/DK0807125T3/da
Priority to KR1019970704893A priority patent/KR100533854B1/ko
Priority to JP51926797A priority patent/JP4113929B2/ja
Priority to US08/875,674 priority patent/US6572857B1/en
Priority to MXPA/A/1997/005445A priority patent/MXPA97005445A/es
Publication of CU22584A1 publication Critical patent/CU22584A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/20Dermatological disorders
    • G01N2800/205Scaling palpular diseases, e.g. psoriasis, pytiriasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con la rama de la Inmunología y en particular con la obtención de composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario CD6. De acuerdo con lo expuesto, el objeto de esta invención es proporcionar composiciones farmacéuticas que contengan un anticuerpo monoclonal anti CD6 para el diagnóstico y tratamiento de lesiones cutáneas de la Psoriasis Vulgar. La esencia de la invención consiste en aplicar un anticuerpo monoclonal que reconoce el antígeno CD&, obtener composiciones farmacéuticas que contengan este anticuerpo y sean capaces de lograr una efectividad clínica e histológica en pacientes con las diferentes formas clínicas de la Psoriasis. El campo de aplicación de la presente invención se extiende a la Dermatología.
CU1995120A 1995-11-17 1995-11-17 Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis CU22584A1 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CU1995120A CU22584A1 (es) 1995-11-17 1995-11-17 Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis
CA002210751A CA2210751C (en) 1995-11-17 1996-11-18 Anti-cd6 monoclonal antibodies and their uses
PCT/CU1996/000004 WO1997019111A2 (es) 1995-11-17 1996-11-18 Anticuerpos monoclonales anti-cd6 y sus utilizaciones
AU76905/96A AU722882B2 (en) 1995-11-17 1996-11-18 Anti-CD6 monoclonal antibodies and their uses
EP96939805A EP0807125B1 (en) 1995-11-17 1996-11-18 Monoclonal antibodies anti-cd6 for the treatment and diagnosis of psoriasis
ES96939805T ES2231826T3 (es) 1995-11-17 1996-11-18 Anticuerpos monoclonales anti-cd6 para el tratamiento y el diagnostico de la psoriasis.
CNB96192098XA CN1222540C (zh) 1995-11-17 1996-11-18 抗cd6的单克隆抗体和它们的用途
DE69633717T DE69633717T2 (de) 1995-11-17 1996-11-18 Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis
AT96939805T ATE280783T1 (de) 1995-11-17 1996-11-18 Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis
BRPI9607171A BRPI9607171B1 (pt) 1995-11-17 1996-11-18 anticorpo monoclonal anti-cd6 humano, usos dos mesmos para o diagnóstico in vitro de psoríase, composição farmacêutica e reagente contendo o dito anticorpo
PT96939805T PT807125E (pt) 1995-11-17 1996-11-18 Anticorpos monoclonais anti-cd6 para o tratamento e diagnose da psoriase
DK96939805T DK0807125T3 (da) 1995-11-17 1996-11-18 Monoklonale antistoffer mod CD6 til behandling og diagnosticering af psoriasis
KR1019970704893A KR100533854B1 (ko) 1995-11-17 1996-11-18 항-cd6 단일클론항체 및 이를 포함하는 건선치료용 약제조성물
JP51926797A JP4113929B2 (ja) 1995-11-17 1996-11-18 アンチcd6モノクロナール抗体とその利用
US08/875,674 US6572857B1 (en) 1995-11-17 1996-11-18 Anti-CD6 monoclonal antibodies and their uses
MXPA/A/1997/005445A MXPA97005445A (es) 1995-11-17 1997-07-17 Anticuerpos monoclonales anti-cd6 y sus usos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1995120A CU22584A1 (es) 1995-11-17 1995-11-17 Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis

Publications (1)

Publication Number Publication Date
CU22584A1 true CU22584A1 (es) 1999-11-03

Family

ID=5459401

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1995120A CU22584A1 (es) 1995-11-17 1995-11-17 Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis

Country Status (15)

Country Link
US (1) US6572857B1 (es)
EP (1) EP0807125B1 (es)
JP (1) JP4113929B2 (es)
KR (1) KR100533854B1 (es)
CN (1) CN1222540C (es)
AT (1) ATE280783T1 (es)
AU (1) AU722882B2 (es)
BR (1) BRPI9607171B1 (es)
CA (1) CA2210751C (es)
CU (1) CU22584A1 (es)
DE (1) DE69633717T2 (es)
DK (1) DK0807125T3 (es)
ES (1) ES2231826T3 (es)
PT (1) PT807125E (es)
WO (1) WO1997019111A2 (es)

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WO2001091793A1 (en) * 2000-05-26 2001-12-06 Smithkline Beecham Corporation Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders
CU23097A1 (es) * 2002-10-23 2005-11-18 Centro Inmunologia Molecular Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método
CA2516971A1 (en) 2003-02-24 2004-09-02 Institut Pasteur Secreted chlamydia polypeptides, polynucleotides coding therefor, therapeutic and diagnostic uses thereof
UY30838A1 (es) * 2006-12-26 2008-07-31 Centro Inmunologia Molecular Composicion farmacéutica que comprende un anticuerpo monoclonal anti cd6 utilizado en el diagnostico y tratamiento de la artritis reumatoide
RU2454245C2 (ru) * 2006-12-26 2012-06-27 Сентро Де Инмунология Молекулар Фармацевтические композиции, способные вызывать апоптоз опухолевых клеток, для диагностики и лечения в-клеточной хронической лимфоцитарной лейкемии
AU2009204467B2 (en) 2008-01-11 2012-09-06 Adheron Therapeutics, Inc. Cadherin-11 ECl domain antagonists for treating inflammatory joint disorders
NZ587632A (en) * 2008-03-14 2012-06-29 Biocon Ltd An anti-cd6 monoclonal antibody and a method thereof
MX343376B (es) * 2010-07-15 2016-11-03 Adheron Therapeutics Inc Anticuerpos humanizados que tienen como objetivo el dominio ec1 de cadherina-11 y composiciones y metodos relacionados.
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
AU2012279225A1 (en) 2011-07-01 2014-01-16 Beckman Coulter, Inc. Regulatory T cells and methods of identifying, obtaining and using to treat immuno-based disorders
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
FR3000216B1 (fr) * 2012-12-21 2015-02-06 Galderma Res & Dev Utilisation de proteases particulieres pour la detection de trichophytons et de pathologies associees
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
KR102405247B1 (ko) 2013-07-23 2022-06-07 바이오콘 리미티드 Cd6 결합 파트너의 용도 및 이에 기초한 방법
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
CN105504062B (zh) * 2015-12-25 2019-06-04 百泰生物药业有限公司 一种抗CD6单抗T1h的检测性抗体及应用
PL3529274T3 (pl) * 2016-10-21 2024-09-09 Biocon Limited Przeciwciało monoklonalne i sposób jego stosowania w leczeniu tocznia
KR20200128415A (ko) 2018-02-27 2020-11-12 이퀼리엄 아이엔씨 중증 천식 치료를 위한 항 cd6 항체
AU2019295855B2 (en) 2018-06-29 2026-04-23 City Of Hope CD6 targeted chimeric antigen receptors for treatment of certain autoimmune disorders
CA3131299A1 (en) 2019-02-26 2020-09-03 Equillium, Inc. Anti-cd6 antibody compositions and methods for treating lupus
US20230076643A1 (en) 2019-12-30 2023-03-09 City Of Hope Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers
US20230151107A1 (en) * 2020-04-04 2023-05-18 Biocon Limited Anti-cd6 antibody compositions and methods for treating and reducing negative effects of a coronavirus including covid-19
AU2022344418A1 (en) 2021-09-08 2024-04-04 Centro De Inmunologia Molecular Use of anti-cd6 monoclonal antibodies in the prevention of cellular and organ damage resulting from hyper- inflammatory response
WO2025096685A1 (en) 2023-10-30 2025-05-08 City Of Hope Methods of making and using regulatory t cells for treatment of autoimmune disorders and cancers
CN120005027B (zh) * 2025-04-10 2025-09-23 中国水产科学研究院长江水产研究所 大口黑鲈cd6抗原结合肽、及其单克隆抗体和应用

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Also Published As

Publication number Publication date
ATE280783T1 (de) 2004-11-15
ES2231826T3 (es) 2005-05-16
MX9705445A (es) 1998-06-30
CN1222540C (zh) 2005-10-12
KR100533854B1 (ko) 2006-09-20
KR19980701502A (ko) 1998-05-15
EP0807125A2 (en) 1997-11-19
US6572857B1 (en) 2003-06-03
CA2210751C (en) 2007-01-30
WO1997019111A3 (es) 1998-02-12
DK0807125T3 (da) 2005-03-14
CA2210751A1 (en) 1997-05-29
JPH11506017A (ja) 1999-06-02
AU7690596A (en) 1997-06-11
PT807125E (pt) 2005-03-31
WO1997019111A2 (es) 1997-05-29
BR9607171A (pt) 1997-11-11
DE69633717T2 (de) 2006-02-02
AU722882B2 (en) 2000-08-10
EP0807125B1 (en) 2004-10-27
JP4113929B2 (ja) 2008-07-09
CN1175957A (zh) 1998-03-11
DE69633717D1 (de) 2004-12-02
BRPI9607171B1 (pt) 2016-07-19

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