CU22615A1 - Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos - Google Patents

Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos

Info

Publication number
CU22615A1
CU22615A1 CU1994080A CU1994080A CU22615A1 CU 22615 A1 CU22615 A1 CU 22615A1 CU 1994080 A CU1994080 A CU 1994080A CU 1994080 A CU1994080 A CU 1994080A CU 22615 A1 CU22615 A1 CU 22615A1
Authority
CU
Cuba
Prior art keywords
mammalian species
monoclonal antibodies
variable domains
less immunogenic
chimaeric antibodies
Prior art date
Application number
CU1994080A
Other languages
English (en)
Inventor
De Acosta Del Rio Cristina Maria Mateo
Valladares Josefa Lombardero
Rodriguez Rolando Perez
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Priority to CU1994080A priority Critical patent/CU22615A1/es
Priority to ES95201752T priority patent/ES2220918T3/es
Priority to AT95201752T priority patent/ATE265531T1/de
Priority to PT95201752T priority patent/PT699755E/pt
Priority to DE69532940T priority patent/DE69532940T2/de
Priority to DK95201752T priority patent/DK0699755T3/da
Priority to EP95201752A priority patent/EP0699755B1/en
Priority to CNB951091484A priority patent/CN1279168C/zh
Priority to US08/497,312 priority patent/US5712120A/en
Priority to JP16651395A priority patent/JP3238049B2/ja
Priority to CA002153135A priority patent/CA2153135C/en
Publication of CU22615A1 publication Critical patent/CU22615A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se relaciona con la rama de la inmunología y en particular con un procedimiento de obtención de inmunoglobulinas menos inmunogénicas a partir de anticuerpos monoclonales murinos, y las formulaciones que contengan estas inmunoglobinas modificadas. De acuerdo con lo expuesto, el objeto de esta invención es proporcionar un método para la obtención de anticuerpos monoclonales modificados, generados a partir de linfocitos de ratón y que resulten menos inmunogénicos al utilizarse en humanos. La esencia de la invención consiste en romper la inmunogenicidad T de una inmunoglobulina murina, sustituyendo en los marcos (FRs) de la región variable de la misma aquellos aminoácidos que están involucrados en los epitopos T que se predicen con los diferentes algoritmos, por los residuos que se encuentran presentes en la misma posición, en la secuencia de una inmunoglobulina humana, sin afectar la afinidad de su unión con el antígeno. La reducción de la inmunogenicidad de los anticuerpos monoclonales murinos se comprenderá mejor a través de la siguiente descripción y ejemplos.
CU1994080A 1994-06-30 1994-06-30 Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos CU22615A1 (es)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CU1994080A CU22615A1 (es) 1994-06-30 1994-06-30 Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
ES95201752T ES2220918T3 (es) 1994-06-30 1995-06-27 Metodo para obtencion de inmunoglobulinas modificadas con inmunogenicidad reducida de dominios variables de un anticuerpo murino y composiciones que los contienen.
AT95201752T ATE265531T1 (de) 1994-06-30 1995-06-27 Verfahren zur herstellung modifizierter immunoglobulinen mit reduzierter immunogenität der variablen domänen einer murinen antikörpers, zusammensetzungen die diese enthalten
PT95201752T PT699755E (pt) 1994-06-30 1995-06-27 Metodo para obtencao de imunoglobulinas modificadas com imunogenicidade reduzida de dominios variaveis de anticorpos de murideo composicoes que as contem
DE69532940T DE69532940T2 (de) 1994-06-30 1995-06-27 Verfahren zur Herstellung modifizierter Immunoglobuline mit verminderter Immunogenität der variablen Domänen eines Antikörpers der Maus, Zusammensetzungen, die diese enthalten
DK95201752T DK0699755T3 (da) 1994-06-30 1995-06-27 Fremgangsmåde til opnåelse af modificerede immunglobuliner med reduceret immunogenicitet af variable domæner i et murint antistof, præparater der indeholder disse
EP95201752A EP0699755B1 (en) 1994-06-30 1995-06-27 Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
CNB951091484A CN1279168C (zh) 1994-06-30 1995-06-30 得到经过修饰降低了鼠抗体可变区之免疫原性的免疫球蛋白的方法及含有免疫球蛋白的组合物
US08/497,312 US5712120A (en) 1994-06-30 1995-06-30 Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
JP16651395A JP3238049B2 (ja) 1994-06-30 1995-06-30 マウス抗体可変部ドメインの免疫原性を減弱させた修飾免疫グロブリンの取得方法およびそれらを含有する組成物
CA002153135A CA2153135C (en) 1994-06-30 1995-06-30 Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU1994080A CU22615A1 (es) 1994-06-30 1994-06-30 Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos

Publications (1)

Publication Number Publication Date
CU22615A1 true CU22615A1 (es) 2000-02-10

Family

ID=5459314

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1994080A CU22615A1 (es) 1994-06-30 1994-06-30 Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos

Country Status (11)

Country Link
US (1) US5712120A (es)
EP (1) EP0699755B1 (es)
JP (1) JP3238049B2 (es)
CN (1) CN1279168C (es)
AT (1) ATE265531T1 (es)
CA (1) CA2153135C (es)
CU (1) CU22615A1 (es)
DE (1) DE69532940T2 (es)
DK (1) DK0699755T3 (es)
ES (1) ES2220918T3 (es)
PT (1) PT699755E (es)

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EP0699755A2 (en) 1996-03-06
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CA2153135C (en) 2005-06-07
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ATE265531T1 (de) 2004-05-15
PT699755E (pt) 2004-09-30
JPH08280387A (ja) 1996-10-29
CN1133886A (zh) 1996-10-23
EP0699755A3 (en) 1996-06-12
US5712120A (en) 1998-01-27
CN1279168C (zh) 2006-10-11
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CA2153135A1 (en) 1995-12-31
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