CU23047A3 - Derivados de aminoacidos halogenados utiles como inhibidores de la oxido nitrico-sintasa. - Google Patents

Derivados de aminoacidos halogenados utiles como inhibidores de la oxido nitrico-sintasa.

Info

Publication number
CU23047A3
CU23047A3 CU20000199A CU20000199A CU23047A3 CU 23047 A3 CU23047 A3 CU 23047A3 CU 20000199 A CU20000199 A CU 20000199A CU 20000199 A CU20000199 A CU 20000199A CU 23047 A3 CU23047 A3 CU 23047A3
Authority
CU
Cuba
Prior art keywords
nitrico
sintasa
inhibitors
derivatives
oxide
Prior art date
Application number
CU20000199A
Other languages
English (en)
Inventor
E Ann Hallinan
Barnett S Pitzel
Dale P Spangler
Arija A Bergmanis
Timothy J Hagen
Sofya Tsymbalov
Mihaly V Toth
R Keith Webber
Donald W Hansen Jr
Alik K Awasthi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of CU23047A3 publication Critical patent/CU23047A3/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CU20000199A 1998-03-11 1999-03-04 Derivados de aminoacidos halogenados utiles como inhibidores de la oxido nitrico-sintasa. CU23047A3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3828498A 1998-03-11 1998-03-11
PCT/US1999/003728 WO1999046240A2 (en) 1998-03-11 1999-03-04 Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
CU23047A3 true CU23047A3 (es) 2005-04-26

Family

ID=21899068

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20000199A CU23047A3 (es) 1998-03-11 1999-03-04 Derivados de aminoacidos halogenados utiles como inhibidores de la oxido nitrico-sintasa.

Country Status (35)

Country Link
US (1) US6344483B1 (es)
EP (2) EP1062201B1 (es)
JP (1) JP2002506056A (es)
KR (1) KR20010034598A (es)
CN (1) CN1171861C (es)
AP (1) AP2000001900A0 (es)
AR (1) AR018159A1 (es)
AT (1) ATE277894T1 (es)
AU (1) AU746235B2 (es)
BG (1) BG104766A (es)
BR (1) BR9908702A (es)
CA (1) CA2322873A1 (es)
CU (1) CU23047A3 (es)
DE (1) DE69920670T2 (es)
EA (1) EA200000826A1 (es)
EE (1) EE200000519A (es)
ES (1) ES2239839T3 (es)
GE (1) GEP20043179B (es)
HR (1) HRP20000595A2 (es)
HU (1) HUP0101467A3 (es)
ID (1) ID26208A (es)
IL (1) IL137654A0 (es)
IS (1) IS5583A (es)
NO (1) NO20004531L (es)
NZ (1) NZ506721A (es)
OA (1) OA11901A (es)
PL (1) PL343380A1 (es)
PT (1) PT1062201E (es)
SI (1) SI1062201T1 (es)
SK (1) SK13012000A3 (es)
TR (1) TR200002605T2 (es)
UA (1) UA67767C2 (es)
WO (1) WO1999046240A2 (es)
YU (1) YU52200A (es)
ZA (1) ZA991894B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1265859T3 (da) 2000-03-24 2006-05-01 Pharmacia Corp Amidinoforbindelser der er nyttige som nitrogenoxidsyntaseinhibitorer
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6956131B2 (en) * 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
AR034120A1 (es) * 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
GB0031179D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20040087653A1 (en) * 2002-05-16 2004-05-06 Manning Pamela T. Methods for the treatment of respiratory diseases and conditions with a selective iNOS inhibitor and a PDE inhibitor and compositions therefor
MX2007007590A (es) 2004-12-22 2007-12-10 Ambrx Inc Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
MX2007011409A (es) * 2005-03-14 2008-02-22 Johnson & Johnson Procedimiento de preparacion de moduladores opioides.
HRP20110404T1 (hr) * 2005-11-08 2011-08-31 Ambrx Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina
ES2529065T3 (es) * 2005-12-14 2015-02-16 Ambrx, Inc. Composiciones que contienen, procedimientos que implican y usos de aminoácidos no naturales y polipéptidos
KR101103720B1 (ko) * 2011-06-02 2012-01-11 한국건설기술연구원 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝
CN105744944B (zh) 2013-09-09 2020-07-07 卡尼姆盖德治疗学公司 免疫系统调节器
WO2016144650A1 (en) 2015-03-06 2016-09-15 Canimguide Therapeutics Ab Immune system modulators and compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
SI0765308T1 (sl) 1994-06-15 2000-08-31 The Wellcome Foundation Limited Encimski inhibitorji
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
AP2000001900A0 (en) 2000-09-30
NO20004531D0 (no) 2000-09-11
IL137654A0 (en) 2001-10-31
ID26208A (id) 2000-11-07
YU52200A (sh) 2002-09-19
CA2322873A1 (en) 1999-09-16
JP2002506056A (ja) 2002-02-26
ES2239839T3 (es) 2005-10-01
TR200002605T2 (tr) 2000-12-21
EP1062201A2 (en) 2000-12-27
CN1171861C (zh) 2004-10-20
BR9908702A (pt) 2000-11-21
EP1415982A1 (en) 2004-05-06
HUP0101467A2 (hu) 2001-08-28
SI1062201T1 (en) 2005-10-31
AR018159A1 (es) 2001-10-31
NZ506721A (en) 2003-07-25
DE69920670D1 (de) 2004-11-04
HUP0101467A3 (en) 2003-03-28
UA67767C2 (uk) 2004-07-15
NO20004531L (no) 2000-10-30
PL343380A1 (en) 2001-08-13
EP1062201B1 (en) 2004-09-29
WO1999046240A2 (en) 1999-09-16
ATE277894T1 (de) 2004-10-15
HRP20000595A2 (en) 2001-04-30
ZA991894B (en) 1999-09-27
OA11901A (en) 2006-04-10
SK13012000A3 (sk) 2001-06-11
IS5583A (is) 2000-08-04
CN1292779A (zh) 2001-04-25
EE200000519A (et) 2002-02-15
US6344483B1 (en) 2002-02-05
WO1999046240A3 (en) 1999-11-11
BG104766A (bg) 2001-03-30
GEP20043179B (en) 2004-02-25
DE69920670T2 (de) 2006-02-16
PT1062201E (pt) 2005-02-28
KR20010034598A (ko) 2001-04-25
EA200000826A1 (ru) 2001-04-23
AU746235B2 (en) 2002-04-18
AU2778699A (en) 1999-09-27

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