CU23178A1 - INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA - Google Patents

INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA

Info

Publication number
CU23178A1
CU23178A1 CU20020076A CU20020076A CU23178A1 CU 23178 A1 CU23178 A1 CU 23178A1 CU 20020076 A CU20020076 A CU 20020076A CU 20020076 A CU20020076 A CU 20020076A CU 23178 A1 CU23178 A1 CU 23178A1
Authority
CU
Cuba
Prior art keywords
active
receptors
antiangiogen
immunotherapy
active immunotherapy
Prior art date
Application number
CU20020076A
Other languages
English (en)
Inventor
Rodriguez Ernesto Galban
Lasa Alexis Musachio
Ocejo Omar Lopez
Romero Monica Bequet
Blomquist Dania Marcia Vazquez
Castro Boris Ernesto Acevedo
Molina Luis Enrique Fernandez
Cowley Jorge Victor Gavilondo
Rodriguez Ricardo De La Silva
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20020076A priority Critical patent/CU23178A1/es
Priority to ARP030101264A priority patent/AR039285A1/es
Priority to EP03711811A priority patent/EP1502599B1/en
Priority to PCT/CU2003/000004 priority patent/WO2003086450A1/es
Priority to RU2004133338/15A priority patent/RU2329824C2/ru
Priority to CN03808567.4A priority patent/CN1646153B/zh
Priority to PT03711811T priority patent/PT1502599E/pt
Priority to AU2003218603A priority patent/AU2003218603B2/en
Priority to ES03711811T priority patent/ES2365329T3/es
Priority to CA2480079A priority patent/CA2480079C/en
Priority to US10/511,384 priority patent/US7556809B2/en
Priority to DK03711811.4T priority patent/DK1502599T3/da
Priority to AT03711811T priority patent/ATE511851T1/de
Priority to KR1020047016584A priority patent/KR100704127B1/ko
Priority to JP2003583468A priority patent/JP4741800B2/ja
Priority to SI200332037T priority patent/SI1502599T1/sl
Priority to ZA200408460A priority patent/ZA200408460B/xx
Publication of CU23178A1 publication Critical patent/CU23178A1/es
Priority to US11/787,522 priority patent/US20080254050A1/en
Priority to US12/612,455 priority patent/US8883724B2/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
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    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001109—Vascular endothelial growth factor receptors [VEGFR]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Aplicacion de secuencias oligonucleotídicas y polipÉotidas de molÉculas pertenecientes a la familia del factor de permeabilidad vascular (VPF), sus receptores y correceptores; así como modificaciones de los mismos, en la inmunoterapia activa de entidades patologicas cuyo curso se asocia al aumento de la vasculatura. Estos procedimientos pueden ser empleados en la terpaia Unica o combinada para el tratamiento del cAncer y sus metAstasis, los procesos inflamatorios agudos y cronicos, enfermedades infecciosas, enfermedades autoinmunes, la retinopatía diabÉtica y del reciÉn nacido, el rechazo a trasplante de organos, la degeneracion macular, los glaucomas neovasculares, hemangiomas y los angiofibromas, entre otros.
CU20020076A 2002-04-15 2002-04-15 INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA CU23178A1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CU20020076A CU23178A1 (es) 2002-04-15 2002-04-15 INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA
ARP030101264A AR039285A1 (es) 2002-04-15 2003-04-10 Inmunoterapia activa antiangiogenica composicion vacunal
CA2480079A CA2480079C (en) 2002-04-15 2003-04-11 Antiangiogenic active immunotherapy
DK03711811.4T DK1502599T3 (da) 2002-04-15 2003-04-11 Anvendelse af muteret VEGF til antiangiogen terapi
RU2004133338/15A RU2329824C2 (ru) 2002-04-15 2003-04-11 Активная иммунотерапия против ангиогенеза
CN03808567.4A CN1646153B (zh) 2002-04-15 2003-04-11 抗血管生成的主动免疫疗法
PT03711811T PT1502599E (pt) 2002-04-15 2003-04-11 Terapia anti-angiogénica activa
AU2003218603A AU2003218603B2 (en) 2002-04-15 2003-04-11 Active antiangiogenic therapy
ES03711811T ES2365329T3 (es) 2002-04-15 2003-04-11 Uso de vegf mutado para la terapia antiangiogenica.
EP03711811A EP1502599B1 (en) 2002-04-15 2003-04-11 Use of mutated VEGF for antiangiogenic therapy
US10/511,384 US7556809B2 (en) 2002-04-15 2003-04-11 Active antiangiogenic therapy
PCT/CU2003/000004 WO2003086450A1 (es) 2002-04-15 2003-04-11 Inmunoterapia activa antiangiogenica.
AT03711811T ATE511851T1 (de) 2002-04-15 2003-04-11 Verwendung eines vgefmutants zur antiangiogene therapie
KR1020047016584A KR100704127B1 (ko) 2002-04-15 2003-04-11 혈관형성억제 활성 면역치료
JP2003583468A JP4741800B2 (ja) 2002-04-15 2003-04-11 抗血管新生活性療法
SI200332037T SI1502599T1 (sl) 2002-04-15 2003-04-11 Uporaba mutiranega VEGF za antiangiogenetsko terapijo
ZA200408460A ZA200408460B (en) 2002-04-15 2004-10-19 Active antiangiogenic therapy.
US11/787,522 US20080254050A1 (en) 2002-04-15 2007-04-17 Antiangiogenic active immunotherapy
US12/612,455 US8883724B2 (en) 2002-04-15 2009-11-04 Active antiangiogenic therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20020076A CU23178A1 (es) 2002-04-15 2002-04-15 INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA

Publications (1)

Publication Number Publication Date
CU23178A1 true CU23178A1 (es) 2006-09-22

Family

ID=40134850

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20020076A CU23178A1 (es) 2002-04-15 2002-04-15 INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA

Country Status (17)

Country Link
US (3) US7556809B2 (es)
EP (1) EP1502599B1 (es)
JP (1) JP4741800B2 (es)
KR (1) KR100704127B1 (es)
CN (1) CN1646153B (es)
AR (1) AR039285A1 (es)
AT (1) ATE511851T1 (es)
AU (1) AU2003218603B2 (es)
CA (1) CA2480079C (es)
CU (1) CU23178A1 (es)
DK (1) DK1502599T3 (es)
ES (1) ES2365329T3 (es)
PT (1) PT1502599E (es)
RU (1) RU2329824C2 (es)
SI (1) SI1502599T1 (es)
WO (1) WO2003086450A1 (es)
ZA (1) ZA200408460B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23178A1 (es) * 2002-04-15 2006-09-22 Ct Ingenieria Genetica Biotech INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA
DK2261249T3 (en) 2002-09-12 2015-02-16 Oncotherapy Science Inc KDR peptides and vaccines comprising the same
ATE470454T1 (de) * 2004-09-13 2010-06-15 Genzyme Corp Multimere konstrukte
ES2435650T3 (es) 2005-02-28 2013-12-20 Oncotherapy Science, Inc. Péptidos epítopos derivados del receptor 1 del factor de crecimiento endotelial vascular y vacunas que contienen estos péptidos
US20060234941A1 (en) * 2005-04-15 2006-10-19 The Gov. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Peptide epitopes of VEGFR-2/KDR that inhibit angiogenesis
KR20080087164A (ko) 2006-01-18 2008-09-30 더 제너럴 하스피탈 코포레이션 림프 기능을 증가시키는 방법
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