CU23422B7 - HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES - Google Patents

HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES

Info

Publication number
CU23422B7
CU23422B7 CU20040254A CU20040254A CU23422B7 CU 23422 B7 CU23422 B7 CU 23422B7 CU 20040254 A CU20040254 A CU 20040254A CU 20040254 A CU20040254 A CU 20040254A CU 23422 B7 CU23422 B7 CU 23422B7
Authority
CU
Cuba
Prior art keywords
pain
derivatives
tetrahydro
useful
treatment
Prior art date
Application number
CU20040254A
Other languages
Spanish (es)
Inventor
Yasuhiro Tsukimi
Masaomi Tajimi
Mashiro Shiroo
Toshiya Moriwaki
Hiroshi Fujishima
Klaus Urbahns
Tsutomu Masuda
Nagahiro Yoshida
Nuriyuki Yamamoto
Muneto Mogi
Toshio Kokubo
Takeshi Yura
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CU23422B7 publication Critical patent/CU23422B7/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención se refiere a derivados de tetrahidro-naftaleno y a sales del mismo que son útiles como ingredientes activo de preparaciones farcéuticas. Los derivados de tetrahidro-naftaleno de la presente invención tienen una excelente actividad como antagonista de VR1 y es útil para la prevención y tratamiento de enfermedades relacianadas con la actividad de VR1, en particular para el tratamiento de incontinencia urinaria de urgencia , vejiga hiperactiva, dolor crónico, dolor neuropático, dolor postoperatorio, dolor por artritis reumatoide, neuralgia, neuropatías, algesia, lesión nerviosa, isquemia, neurodegeneración, apoplejía, incontinencia, trastornos inflamatorios, asma y COPD.This invention relates to tetrahydro-naphthalene derivatives and salts thereof that are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as an antagonist of VR1 and is useful for the prevention and treatment of diseases related to the activity of VR1, in particular for the treatment of urinary incontinence of urgency, overactive bladder, pain Chronic, neuropathic pain, postoperative pain, rheumatoid arthritis pain, neuralgia, neuropathies, algesia, nerve injury, ischemia, neurodegeneration, stroke, incontinence, inflammatory disorders, asthma and COPD.

CU20040254A 2002-05-08 2004-11-04 HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES CU23422B7 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0210512.0A GB0210512D0 (en) 2002-05-08 2002-05-08 Tetrahydro-napthalene derivatives
GBGB0227262.3A GB0227262D0 (en) 2002-05-08 2002-11-21 Tetrahydro-naphthalene derivatives

Publications (1)

Publication Number Publication Date
CU23422B7 true CU23422B7 (en) 2009-09-08

Family

ID=9936269

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20040254A CU23422B7 (en) 2002-05-08 2004-11-04 HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES

Country Status (13)

Country Link
KR (1) KR101000688B1 (en)
AR (1) AR039983A1 (en)
CU (1) CU23422B7 (en)
DO (1) DOP2003000642A (en)
EC (1) ECSP045413A (en)
GB (2) GB0210512D0 (en)
GT (1) GT200300102A (en)
MA (1) MA30728B1 (en)
MY (1) MY155011A (en)
PE (1) PE20040363A1 (en)
PT (1) PT1506167E (en)
UA (1) UA77301C2 (en)
ZA (1) ZA200408993B (en)

Also Published As

Publication number Publication date
PT1506167E (en) 2007-12-10
KR101000688B1 (en) 2010-12-10
GB0227262D0 (en) 2002-12-31
KR20040108784A (en) 2004-12-24
MA30728B1 (en) 2009-10-01
ECSP045413A (en) 2005-01-03
DOP2003000642A (en) 2003-11-15
PE20040363A1 (en) 2004-07-03
GT200300102A (en) 2004-03-17
MY155011A (en) 2015-08-28
GB0210512D0 (en) 2002-06-19
UA77301C2 (en) 2006-11-15
AR039983A1 (en) 2005-03-09
ZA200408993B (en) 2006-01-25

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