ECSP045413A - "DERIVATIVES OF HIDROXI-TETRAHIDRO-NAFTALENILUREA" - Google Patents
"DERIVATIVES OF HIDROXI-TETRAHIDRO-NAFTALENILUREA"Info
- Publication number
- ECSP045413A ECSP045413A EC2004005413A ECSP045413A ECSP045413A EC SP045413 A ECSP045413 A EC SP045413A EC 2004005413 A EC2004005413 A EC 2004005413A EC SP045413 A ECSP045413 A EC SP045413A EC SP045413 A ECSP045413 A EC SP045413A
- Authority
- EC
- Ecuador
- Prior art keywords
- pain
- tetrahydro
- derivatives
- useful
- treatment
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000004296 neuralgia Diseases 0.000 abstract 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 206010020853 Hypertonic bladder Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 abstract 1
- 208000004550 Postoperative Pain Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000020629 overactive bladder Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invención se refiere a derivados de tetrahidro-naftaleno y a sales del mismo que son útiles como ingrediente activo de preparaciones farmacéuticas. Los derivados de tetrahidro-naftaleno de la presente invención una excelente actividad como antagonista de VR1 y es útil para la prevención y tratamiento de enfermedades relacionadas con la actividad de VR1, en particular para el tratamiento de incontinencia urinaria de urgencia, vejiga hiperactiva, dolor crónico, dolor neuropático, dolor postoperatorio, dolor por artritis reumatoide, neuralgia, neuropatías, algesia, lesión nerviosa, isquemia, neurodegeneración, apoplejía, incontinencia, trastornos inflamatorios, asma y COPD.This invention relates to tetrahydro-naphthalene derivatives and salts thereof that are useful as an active ingredient in pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as a VR1 antagonist and is useful for the prevention and treatment of diseases related to the activity of VR1, in particular for the treatment of urinary incontinence of urgency, overactive bladder, chronic pain , neuropathic pain, postoperative pain, rheumatoid arthritis pain, neuralgia, neuropathies, algesia, nerve injury, ischemia, neurodegeneration, stroke, incontinence, inflammatory disorders, asthma and COPD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0210512.0A GB0210512D0 (en) | 2002-05-08 | 2002-05-08 | Tetrahydro-napthalene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045413A true ECSP045413A (en) | 2005-01-03 |
Family
ID=9936269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005413A ECSP045413A (en) | 2002-05-08 | 2004-11-08 | "DERIVATIVES OF HIDROXI-TETRAHIDRO-NAFTALENILUREA" |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR101000688B1 (en) |
| AR (1) | AR039983A1 (en) |
| CU (1) | CU23422B7 (en) |
| DO (1) | DOP2003000642A (en) |
| EC (1) | ECSP045413A (en) |
| GB (2) | GB0210512D0 (en) |
| GT (1) | GT200300102A (en) |
| MA (1) | MA30728B1 (en) |
| MY (1) | MY155011A (en) |
| PE (1) | PE20040363A1 (en) |
| PT (1) | PT1506167E (en) |
| UA (1) | UA77301C2 (en) |
| ZA (1) | ZA200408993B (en) |
-
2002
- 2002-05-08 GB GBGB0210512.0A patent/GB0210512D0/en not_active Ceased
- 2002-11-21 GB GBGB0227262.3A patent/GB0227262D0/en not_active Ceased
-
2003
- 2003-04-28 PT PT03722554T patent/PT1506167E/en unknown
- 2003-04-28 UA UA20041210079A patent/UA77301C2/en unknown
- 2003-04-28 KR KR1020047017969A patent/KR101000688B1/en not_active Expired - Fee Related
- 2003-05-05 GT GT200300102A patent/GT200300102A/en unknown
- 2003-05-06 MY MYPI20031696A patent/MY155011A/en unknown
- 2003-05-07 PE PE2003000445A patent/PE20040363A1/en not_active Application Discontinuation
- 2003-05-07 DO DO2003000642A patent/DOP2003000642A/en unknown
- 2003-05-08 AR ARP030101614A patent/AR039983A1/en active IP Right Grant
-
2004
- 2004-11-04 CU CU20040254A patent/CU23422B7/en unknown
- 2004-11-05 MA MA27935A patent/MA30728B1/en unknown
- 2004-11-05 ZA ZA2004/08993A patent/ZA200408993B/en unknown
- 2004-11-08 EC EC2004005413A patent/ECSP045413A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200408993B (en) | 2006-01-25 |
| GB0210512D0 (en) | 2002-06-19 |
| MY155011A (en) | 2015-08-28 |
| PT1506167E (en) | 2007-12-10 |
| UA77301C2 (en) | 2006-11-15 |
| DOP2003000642A (en) | 2003-11-15 |
| KR101000688B1 (en) | 2010-12-10 |
| AR039983A1 (en) | 2005-03-09 |
| PE20040363A1 (en) | 2004-07-03 |
| KR20040108784A (en) | 2004-12-24 |
| GB0227262D0 (en) | 2002-12-31 |
| MA30728B1 (en) | 2009-10-01 |
| CU23422B7 (en) | 2009-09-08 |
| GT200300102A (en) | 2004-03-17 |
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