CU23471A1 - CHEMERICAL PEPTIDE OF THE TRANSMEMBRANE PROTEIN (GP41) AND THE ENVELOPE PROTEIN (GP120) OF HIV-1 - Google Patents
CHEMERICAL PEPTIDE OF THE TRANSMEMBRANE PROTEIN (GP41) AND THE ENVELOPE PROTEIN (GP120) OF HIV-1Info
- Publication number
- CU23471A1 CU23471A1 CU20040205A CU20040205A CU23471A1 CU 23471 A1 CU23471 A1 CU 23471A1 CU 20040205 A CU20040205 A CU 20040205A CU 20040205 A CU20040205 A CU 20040205A CU 23471 A1 CU23471 A1 CU 23471A1
- Authority
- CU
- Cuba
- Prior art keywords
- protein
- hiv
- peptide
- chemerical
- transmembrane
- Prior art date
Links
- 241000713772 Human immunodeficiency virus 1 Species 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 101710091045 Envelope protein Proteins 0.000 title 1
- 101150048348 GP41 gene Proteins 0.000 title 1
- 101710188315 Protein X Proteins 0.000 title 1
- 102100021696 Syncytin-1 Human genes 0.000 title 1
- 108091005703 transmembrane proteins Proteins 0.000 title 1
- 108091006116 chimeric peptides Proteins 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 150000002333 glycines Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Péptido quimérico obtenido mediante síntesis química en fase sólida, que contiene una secuencia de la proteína gp41 de la transmembrana y la proteína gp120 de la envoltura del VIH-1, separadas por dos glicinas como brazo espaciador. La antigenicidad del péptido quimérico gp41-gp120 fue superior al de los péptidos monoméricos por separado y que su péptido quimérico homólogo gp120-gp41, además de que puede ser utilizado como antígeno para detectar anticuerpos contra más de una proteína simultáneamente. El péptido sintético quimérico puede ser usado como antígeno en ensayos para la detección de anticuerpos específicos al VIH-1, en la certificación de la sangre de donantes y en la vigilancia epidemiológica.Chimeric peptide obtained by solid-phase chemical synthesis, which contains a sequence of the transmembrane gp41 protein and the gp120 protein of the HIV-1 envelope, separated by two glycines as a spacer arm. The antigenicity of the chimeric peptide gp41-gp120 was superior to that of the monomeric peptides separately and that its homologous chimeric peptide gp120-gp41, in addition to that it can be used as an antigen to detect antibodies against more than one protein simultaneously. The chimeric synthetic peptide can be used as an antigen in assays for the detection of antibodies specific to HIV-1, in the certification of donor blood and in epidemiological surveillance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20040205A CU23471A1 (en) | 2004-09-23 | 2004-09-23 | CHEMERICAL PEPTIDE OF THE TRANSMEMBRANE PROTEIN (GP41) AND THE ENVELOPE PROTEIN (GP120) OF HIV-1 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20040205A CU23471A1 (en) | 2004-09-23 | 2004-09-23 | CHEMERICAL PEPTIDE OF THE TRANSMEMBRANE PROTEIN (GP41) AND THE ENVELOPE PROTEIN (GP120) OF HIV-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23471A1 true CU23471A1 (en) | 2009-12-17 |
Family
ID=41694893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20040205A CU23471A1 (en) | 2004-09-23 | 2004-09-23 | CHEMERICAL PEPTIDE OF THE TRANSMEMBRANE PROTEIN (GP41) AND THE ENVELOPE PROTEIN (GP120) OF HIV-1 |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23471A1 (en) |
-
2004
- 2004-09-23 CU CU20040205A patent/CU23471A1/en unknown
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