CU23556A1 - Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico - Google Patents

Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico

Info

Publication number
CU23556A1
CU23556A1 CU20050241A CU20050241A CU23556A1 CU 23556 A1 CU23556 A1 CU 23556A1 CU 20050241 A CU20050241 A CU 20050241A CU 20050241 A CU20050241 A CU 20050241A CU 23556 A1 CU23556 A1 CU 23556A1
Authority
CU
Cuba
Prior art keywords
structure similar
dendrímero
conjugates
obtaining
polymer structure
Prior art date
Application number
CU20050241A
Other languages
English (en)
Inventor
Sanchez Eduardo Fernandez
Martinez Vivian Maria Saez
Odio Fidel Raul Castro
Hernandez Jose Angel Ramon
Meireles Rolando Paez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20050241A priority Critical patent/CU23556A1/es
Priority to BRPI0604313-5A priority patent/BRPI0604313A/pt
Priority to CA2631335A priority patent/CA2631335C/en
Priority to RU2008126209/05A priority patent/RU2409389C2/ru
Priority to CNA2006800491651A priority patent/CN101389354A/zh
Priority to KR1020087015901A priority patent/KR101134983B1/ko
Priority to US12/095,335 priority patent/US8703893B2/en
Priority to MYPI20081872 priority patent/MY150739A/en
Priority to UAA200808587A priority patent/UA91575C2/ru
Priority to CN201510340715.6A priority patent/CN104906594B/zh
Priority to AU2006319636A priority patent/AU2006319636B2/en
Priority to EP06817995.1A priority patent/EP1967212B1/en
Priority to PCT/CU2006/000014 priority patent/WO2007062610A2/es
Priority to JP2008542584A priority patent/JP5123201B2/ja
Priority to ARP060105233A priority patent/AR058841A1/es
Priority to UY29981A priority patent/UY29981A1/es
Priority to ZA200804694A priority patent/ZA200804694B/xx
Priority to EG2008060905A priority patent/EG26619A/en
Publication of CU23556A1 publication Critical patent/CU23556A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

Una estructura polimérica semejante a dendrímero con cuatro ramas de monometoxipolietilénglicol, que puede ser representada como: ESPACIO PARA FÓRMULA El grupo carboxílico de la estructura anterior puede ser funcionalizado para la obtención de cojugados de interés farmacéutico. La unión de este polietilénglicol semejante a dendrímeros a proteínas farmacéuticas mejora la estabilidad in vitro e in vivo de éstas.
CU20050241A 2005-11-30 2005-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico CU23556A1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU20050241A CU23556A1 (es) 2005-11-30 2005-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
BRPI0604313-5A BRPI0604313A (pt) 2005-11-30 2006-10-19 estrutura polimérica semelhante a dendrìmero para a produção de conjugados de interesse farmacêutico
CA2631335A CA2631335C (en) 2005-11-30 2006-11-20 Four branched dendrimer-peg for conjugation to proteins and peptides
RU2008126209/05A RU2409389C2 (ru) 2005-11-30 2006-11-20 Дендример-пэг с четырьмя ветками для конъюгирования с белками и пептидами
CNA2006800491651A CN101389354A (zh) 2005-11-30 2006-11-20 用于与蛋白质和肽缀合的四个支链的树枝状大分子peg
KR1020087015901A KR101134983B1 (ko) 2005-11-30 2006-11-20 단백질 및 펩티드로의 접합을 위한 4개의 분지된덴드리머-폴리에틸렌글리콜
US12/095,335 US8703893B2 (en) 2005-11-30 2006-11-20 Four branched dendrimer-PEG for conjugation to proteins and peptides
MYPI20081872 MY150739A (en) 2005-11-30 2006-11-20 Four branched dendrimer-peg for conjugation to proteins and peptides
UAA200808587A UA91575C2 (ru) 2005-11-30 2006-11-20 Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами
CN201510340715.6A CN104906594B (zh) 2005-11-30 2006-11-20 用于与蛋白质和肽缀合的四个支链的树枝状大分子peg
AU2006319636A AU2006319636B2 (en) 2005-11-30 2006-11-20 Four branched dendrimer-peg for conjugation to proteins and peptides
EP06817995.1A EP1967212B1 (en) 2005-11-30 2006-11-20 Four branched dendrimer-peg for conjugation to proteins and peptides
PCT/CU2006/000014 WO2007062610A2 (es) 2005-11-30 2006-11-20 Dendrímero con peg de cuatro ramas para la conjugación a proteínas y péptidos
JP2008542584A JP5123201B2 (ja) 2005-11-30 2006-11-20 タンパク質及びペプチドに対する結合のための４分枝デンドリマー−ｐｅｇ
ARP060105233A AR058841A1 (es) 2005-11-30 2006-11-28 Estructura polimerica semejante a dendrimero para la obtencion de conjugados de interes farmaceutico
UY29981A UY29981A1 (es) 2005-11-30 2006-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
ZA200804694A ZA200804694B (en) 2005-11-30 2008-05-29 Four branched dendrimer-peg for conjugation to proteins and peptides
EG2008060905A EG26619A (en) 2005-11-30 2008-06-01 PEG-quadrangle arbor polymer for binding to proteins and peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050241A CU23556A1 (es) 2005-11-30 2005-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico

Publications (1)

Publication Number Publication Date
CU23556A1 true CU23556A1 (es) 2010-07-20

Family

ID=37672068

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20050241A CU23556A1 (es) 2005-11-30 2005-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico

Country Status (17)

Country Link
US (1) US8703893B2 (es)
EP (1) EP1967212B1 (es)
JP (1) JP5123201B2 (es)
KR (1) KR101134983B1 (es)
CN (2) CN101389354A (es)
AR (1) AR058841A1 (es)
AU (1) AU2006319636B2 (es)
BR (1) BRPI0604313A (es)
CA (1) CA2631335C (es)
CU (1) CU23556A1 (es)
EG (1) EG26619A (es)
MY (1) MY150739A (es)
RU (1) RU2409389C2 (es)
UA (1) UA91575C2 (es)
UY (1) UY29981A1 (es)
WO (1) WO2007062610A2 (es)
ZA (1) ZA200804694B (es)

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WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
RU2441036C1 (ru) * 2010-09-30 2012-01-27 Общество с ограниченной ответственностью Научно-производственное объединение "Перспектива" (ООО НПО "Перспектива") Способ получения активированного полиэтиленоксида
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
CN104105508B (zh) 2011-12-21 2017-10-24 加利福尼亚大学董事会 药物递送增强的末端树枝状聚合物
US9642916B2 (en) 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
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CU20140003A7 (es) * 2014-01-08 2015-08-27 Ct De Inmunología Molecular Biofarmacuba Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
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US10835578B2 (en) 2016-01-08 2020-11-17 Ascendis Pharma Growth Disorders A/S CNP prodrugs with large carrier moieties
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JP6968802B2 (ja) 2016-01-08 2021-11-17 アセンディス ファーマ グロース ディスオーダーズ エー／エス 環部分にキャリア結合を有するｃｎｐプロドラッグ
CN110392583B (zh) 2016-09-15 2023-01-03 加利福尼亚大学董事会 改进的杂化的末端树枝状聚合物
RU2768747C2 (ru) 2016-09-29 2022-03-24 Асцендис Фарма Гроус Дизордерс А/С Комбинаторная терапия с агонистами cnp контролируемого высвобождения
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Also Published As

Publication number Publication date
KR20080072960A (ko) 2008-08-07
CN104906594B (zh) 2016-12-28
JP5123201B2 (ja) 2013-01-23
EG26619A (en) 2014-04-08
UY29981A1 (es) 2007-06-29
RU2409389C2 (ru) 2011-01-20
US8703893B2 (en) 2014-04-22
CN104906594A (zh) 2015-09-16
US20090082537A1 (en) 2009-03-26
CA2631335A1 (en) 2007-06-07
CA2631335C (en) 2013-07-16
WO2007062610A2 (es) 2007-06-07
BRPI0604313A (pt) 2007-01-30
AU2006319636A1 (en) 2007-06-07
UA91575C2 (ru) 2010-08-10
AU2006319636B2 (en) 2012-10-18
WO2007062610A3 (es) 2007-09-20
RU2008126209A (ru) 2010-01-10
JP2009517414A (ja) 2009-04-30
MY150739A (en) 2014-02-28
ZA200804694B (en) 2009-03-25
EP1967212A2 (en) 2008-09-10
AR058841A1 (es) 2008-02-27
CN101389354A (zh) 2009-03-18
KR101134983B1 (ko) 2012-04-09
EP1967212B1 (en) 2016-09-21

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