BR112012000551A2 - processo para a síntese de conjugados de glicosaminoglicanos (gags) com moléculas biologicamente ativas, conjugados poliméricos e usos relativos dos mesmos. - Google Patents

processo para a síntese de conjugados de glicosaminoglicanos (gags) com moléculas biologicamente ativas, conjugados poliméricos e usos relativos dos mesmos.

Info

Publication number
BR112012000551A2
BR112012000551A2 BR112012000551A BR112012000551A BR112012000551A2 BR 112012000551 A2 BR112012000551 A2 BR 112012000551A2 BR 112012000551 A BR112012000551 A BR 112012000551A BR 112012000551 A BR112012000551 A BR 112012000551A BR 112012000551 A2 BR112012000551 A2 BR 112012000551A2
Authority
BR
Brazil
Prior art keywords
conjugates
gags
synthesis
biologically active
glycosaminoglycan
Prior art date
Application number
BR112012000551A
Other languages
English (en)
Inventor
Antonio Rosato
Davide Renier
Gianfranco Pasut
Matteo D Este
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Publication of BR112012000551A2 publication Critical patent/BR112012000551A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
BR112012000551A 2009-06-16 2010-06-04 processo para a síntese de conjugados de glicosaminoglicanos (gags) com moléculas biologicamente ativas, conjugados poliméricos e usos relativos dos mesmos. BR112012000551A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2009A001065A IT1399351B1 (it) 2009-06-16 2009-06-16 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
PCT/EP2010/003634 WO2010145821A1 (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (gag) with biologically active molecules, polymeric conjugates and relative uses thereof

Publications (1)

Publication Number Publication Date
BR112012000551A2 true BR112012000551A2 (pt) 2016-11-16

Family

ID=41571532

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012000551A BR112012000551A2 (pt) 2009-06-16 2010-06-04 processo para a síntese de conjugados de glicosaminoglicanos (gags) com moléculas biologicamente ativas, conjugados poliméricos e usos relativos dos mesmos.

Country Status (11)

Country Link
US (1) US9034624B2 (pt)
EP (1) EP2443156B1 (pt)
CN (1) CN102803297B (pt)
BR (1) BR112012000551A2 (pt)
CA (1) CA2765739C (pt)
ES (1) ES2600358T3 (pt)
IT (1) IT1399351B1 (pt)
MX (1) MX2011013683A (pt)
RU (1) RU2530649C2 (pt)
SM (2) SMT201700012T1 (pt)
WO (1) WO2010145821A1 (pt)

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JP2011517451A (ja) 2008-03-28 2011-06-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ポリペプチド−ポリマー抱合体およびその使用方法
EP2682409B1 (en) * 2011-03-03 2017-07-05 Chugai Seiyaku Kabushiki Kaisha Derivative of hyaluronic acid modified with amino-carboxylic acid
ITMI20121597A1 (it) * 2012-09-25 2014-03-26 Beta Pharma S A Coniugato tra frammento di parete cellulare batterica ed un veicolo mucopolisaccaridico e suoi usi in ambito medico
CN104357433A (zh) * 2014-11-03 2015-02-18 山东大学 一种6-o-季铵化壳聚糖-超氧化物歧化酶修饰物及其制备
CN104910294B (zh) * 2015-06-05 2017-08-29 西北农林科技大学 一种高分子量去乙酰化透明质酸的制备方法及其应用
KR102944785B1 (ko) 2015-12-09 2026-03-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 안구 질환 또는 장애의 치료 방법
CN106421925B (zh) * 2016-09-08 2019-01-29 中国医学科学院生物医学工程研究所 基于糖胺聚糖仿生细胞外基质水凝胶作为胰岛培养支架的制备方法
JP7216006B2 (ja) 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
EP3661919A4 (en) * 2017-08-02 2021-03-31 Northwestern University SUBSTITUTED FUSION PYRIMIDINE COMPOUNDS AND THEIR USES
KR102954778B1 (ko) 2018-03-09 2026-04-20 발리터 인코포레이티드 관절 염증의 지속적인 관절내 치료를 위한 다가 펩티드 컨쥬게이트
CA3114056A1 (en) * 2018-09-26 2020-04-02 Ascendis Pharma A/S Treatment of infections
US20210393758A1 (en) 2018-10-26 2021-12-23 Istituto Oncologico Veneto Iov-Irccs Hyaluronic acid as a natural adjuvant for protein and peptide-based vaccines
CN113366025A (zh) 2019-01-30 2021-09-07 鲍希与洛姆伯股份有限公司 交联的聚合物网络及其用途
CN114096567A (zh) 2019-04-29 2022-02-25 鲍希与洛姆伯股份有限公司 糖磷脂聚合物网络及其用途
JP7721539B2 (ja) * 2020-08-14 2025-08-12 国立大学法人 東京大学 多糖誘導体、多糖誘導体－薬物コンジュゲート、その製造方法
WO2022034025A1 (en) * 2020-08-14 2022-02-17 Idris Oncology B.V. A process for applying a coating comprising hyaluronic acid onto the surface of a medical sampling device, and the medical sampling device for capture of circulating tumor cells provided with the coating
CN113402633B (zh) * 2021-07-22 2022-04-05 山东大学 一种透明质酸-超氧化物歧化酶结合物及其在皮肤护理产品中的应用
CN114805631A (zh) * 2022-03-01 2022-07-29 吉林省奇健生物技术有限公司 高活性透明质酸-多肽缀合物及其制备方法和应用
CN116239707B (zh) * 2023-05-08 2023-07-14 山东大学 一种胰岛素修饰的肝素衍生物及其制备方法和应用

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
CH666897A5 (fr) 1983-10-11 1988-08-31 Fidia Spa Fractions d'acide hyaluronique non inflammatoire, procedes et compositions pharmaceutiques.
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
IT1317359B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
US7034127B2 (en) 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
AU2006248166B2 (en) * 2005-05-20 2012-11-01 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
RU2343932C1 (ru) * 2007-03-28 2009-01-20 Институт нефтехимии и катализа РАН Способ получения обладающих пониженной растворимостью в воде пленочных материалов на основе модифицированных аминосалициловыми кислотами карбоксилсодержащих полисахаридов
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative

Also Published As

Publication number Publication date
WO2010145821A1 (en) 2010-12-23
EP2443156A1 (en) 2012-04-25
SMT201700012B (it) 2017-03-08
IT1399351B1 (it) 2013-04-16
CN102803297B (zh) 2014-12-10
CA2765739A1 (en) 2010-12-23
SMT201700012T1 (it) 2017-03-08
RU2530649C2 (ru) 2014-10-10
MX2011013683A (es) 2012-01-20
ES2600358T3 (es) 2017-02-08
US9034624B2 (en) 2015-05-19
RU2011151396A (ru) 2013-07-27
HK1176954A1 (en) 2013-08-09
CA2765739C (en) 2017-05-09
US20120114602A1 (en) 2012-05-10
EP2443156B1 (en) 2016-09-28
ITMI20091065A1 (it) 2010-12-17
CN102803297A (zh) 2012-11-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]