CU23636A1 - Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) - Google Patents
Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf)Info
- Publication number
- CU23636A1 CU23636A1 CU20060208A CU20060208A CU23636A1 CU 23636 A1 CU23636 A1 CU 23636A1 CU 20060208 A CU20060208 A CU 20060208A CU 20060208 A CU20060208 A CU 20060208A CU 23636 A1 CU23636 A1 CU 23636A1
- Authority
- CU
- Cuba
- Prior art keywords
- vegf
- molecules
- growth factor
- vitro
- endotelium
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Moléculas polipeptídicas recombinantes relacionadas con anticuerpos, que reconocen específicamente el Factor de Crecimiento de Endotelio Vascular-A (VEGF-A) humano, e interfieren con sus efectos estimulatorios in vitro, y proangiogénicos in vivo. Dichas moléculas polipeptídicas recombinantes son capaces de afectar la proliferación de células endoteliales humanas in vitro, la angiogénesis subcutánea en ratones inducida por tapones de Matrigel que contienen VEGF-A, y el crecimiento de tumores humanos trasplantados a ratones desnudos. Varias de estas moléculas previenen la neovascularización coroidea en un modelo experimental en primates no humanos. Estas moléculas pueden emplearse para inmunoterapia pasiva de entidades patológicas cuyo curso se asocia al aumento de la vasculatura, tales como la degeneración macular asociada a la edad (variante húmeda), el cáncer y sus metástasis, los glaucomas neovasculares, la retinopatía diabética y del recién nacido, los procesos inflamatorios agudos y crónicos, enfermedades infecciosas, enfermedades autoinmunes, el rechazo al trasplante de órganos, los hemangiomas y los angiofibromas, entre otros.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060208A CU23636A1 (es) | 2006-11-01 | 2006-11-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
| MX2009004765A MX2009004765A (es) | 2006-11-01 | 2007-10-30 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf). |
| KR1020097011229A KR20090078363A (ko) | 2006-11-01 | 2007-10-30 | 혈관 내피 성장 인자(ｖｅｇｆ)에 대한 재조합 항체 |
| BRPI0717971-5A2A BRPI0717971A2 (pt) | 2006-11-01 | 2007-10-30 | Anticorpos recombinantes contra o fator de crescimento endotelial vascular (vegf) |
| CA002667594A CA2667594A1 (en) | 2006-11-01 | 2007-10-30 | Recombinant antibodies against vascular endothelial growth factor (vegf) |
| US12/447,711 US20100151566A1 (en) | 2006-11-01 | 2007-10-30 | Recombinant antibodies against the vascular endothelial growth factor (vegf) |
| JP2009534978A JP2010508033A (ja) | 2006-11-01 | 2007-10-30 | 血管内皮増殖因子（ｖｅｇｆ）に対する組換え抗体 |
| RU2009120536/10A RU2009120536A (ru) | 2006-11-01 | 2007-10-30 | Рекомбинантные антитела против васкулярного эндотелиального фактора роста (vegf) |
| EP07817383A EP2093236A1 (en) | 2006-11-01 | 2007-10-30 | Recombinant antibodies against vascular endothelial growth factor (vegf) |
| CNA2007800437331A CN101573379A (zh) | 2006-11-01 | 2007-10-30 | 针对血管内皮生长因子(vegf)的重组抗体 |
| PCT/CU2007/000019 WO2008052489A1 (es) | 2006-11-01 | 2007-10-30 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
| AU2007315484A AU2007315484A1 (en) | 2006-11-01 | 2007-10-30 | Recombinant antibodies against vascular endothelial growth factor (VEGF) |
| ARP070104873A AR063448A1 (es) | 2006-11-01 | 2007-11-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
| ZA200903017A ZA200903017B (en) | 2006-11-01 | 2009-04-30 | Recombinant antibodies against vascular endothelial growth factor (VEGF) |
| CO09056360A CO6341480A2 (es) | 2006-11-01 | 2009-06-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060208A CU23636A1 (es) | 2006-11-01 | 2006-11-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23636A1 true CU23636A1 (es) | 2011-03-21 |
Family
ID=39148565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20060208A CU23636A1 (es) | 2006-11-01 | 2006-11-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100151566A1 (es) |
| EP (1) | EP2093236A1 (es) |
| JP (1) | JP2010508033A (es) |
| KR (1) | KR20090078363A (es) |
| CN (1) | CN101573379A (es) |
| AR (1) | AR063448A1 (es) |
| AU (1) | AU2007315484A1 (es) |
| BR (1) | BRPI0717971A2 (es) |
| CA (1) | CA2667594A1 (es) |
| CO (1) | CO6341480A2 (es) |
| CU (1) | CU23636A1 (es) |
| MX (1) | MX2009004765A (es) |
| RU (1) | RU2009120536A (es) |
| WO (1) | WO2008052489A1 (es) |
| ZA (1) | ZA200903017B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101093717B1 (ko) * | 2008-11-26 | 2011-12-19 | 한국생명공학연구원 | Ｖｅｇｆ―특이적인 인간항체 |
| RU2412251C1 (ru) * | 2009-06-15 | 2011-02-20 | Юрий Леонидович Дорохов | Антитело против фактора роста эндотелия сосудов и способ продукции антитела в растении |
| CU23895B1 (es) * | 2010-12-28 | 2013-05-31 | Biorec Sa | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables |
| CN103012588A (zh) * | 2011-09-23 | 2013-04-03 | 武汉吉天朋生物科技发展有限公司 | 利用具有中和VEGFA生物学活性的McAb应用于肿瘤的靶向治疗 |
| CN104073502B (zh) * | 2013-03-26 | 2016-08-24 | 华东师范大学 | 人脑钠肽的中和性基因工程抗体3c1及其制备方法和应用 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CL2014002941A1 (es) * | 2014-10-30 | 2015-04-06 | Univ Concepcion | Moléculas polipeptídicas contra el factor de crecimiento del endotelio vascular (vegf) |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CU24637B1 (es) * | 2019-12-24 | 2022-12-12 | Ct Ingenieria Genetica Biotecnologia | Polipéptidos que comprenden mutantes del vegf-a humano con re-arreglos de puentes disulfuro y composiciones que los contienen |
| CU24770B1 (es) | 2021-12-15 | 2025-09-01 | Ct Ingenieria Genetica Biotecnologia | Polipéptidos que se unen al factor de crecimiento del endotelio vascular y al factor básico de crecimiento de fibroblastos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DK0438200T3 (da) | 1990-01-16 | 2002-11-11 | Ct Ingenieria Genetica Biotech | Fremgangsmåde til ekspression af heterologe gener i gæren Pichia pastoris, ekspressionsvektorer og transformerede mikroorganismer |
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2006
- 2006-11-01 CU CU20060208A patent/CU23636A1/es unknown
-
2007
- 2007-10-30 WO PCT/CU2007/000019 patent/WO2008052489A1/es not_active Ceased
- 2007-10-30 AU AU2007315484A patent/AU2007315484A1/en not_active Abandoned
- 2007-10-30 JP JP2009534978A patent/JP2010508033A/ja not_active Abandoned
- 2007-10-30 CN CNA2007800437331A patent/CN101573379A/zh active Pending
- 2007-10-30 BR BRPI0717971-5A2A patent/BRPI0717971A2/pt not_active IP Right Cessation
- 2007-10-30 CA CA002667594A patent/CA2667594A1/en not_active Abandoned
- 2007-10-30 US US12/447,711 patent/US20100151566A1/en not_active Abandoned
- 2007-10-30 KR KR1020097011229A patent/KR20090078363A/ko not_active Withdrawn
- 2007-10-30 RU RU2009120536/10A patent/RU2009120536A/ru not_active Application Discontinuation
- 2007-10-30 MX MX2009004765A patent/MX2009004765A/es unknown
- 2007-10-30 EP EP07817383A patent/EP2093236A1/en not_active Withdrawn
- 2007-11-01 AR ARP070104873A patent/AR063448A1/es not_active Application Discontinuation
-
2009
- 2009-04-30 ZA ZA200903017A patent/ZA200903017B/xx unknown
- 2009-06-01 CO CO09056360A patent/CO6341480A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20100151566A1 (en) | 2010-06-17 |
| MX2009004765A (es) | 2009-06-05 |
| CA2667594A1 (en) | 2008-05-08 |
| BRPI0717971A2 (pt) | 2013-11-12 |
| WO2008052489A8 (es) | 2009-07-23 |
| JP2010508033A (ja) | 2010-03-18 |
| WO2008052489A1 (es) | 2008-05-08 |
| CO6341480A2 (es) | 2011-11-21 |
| CN101573379A (zh) | 2009-11-04 |
| ZA200903017B (en) | 2010-03-31 |
| KR20090078363A (ko) | 2009-07-17 |
| RU2009120536A (ru) | 2010-12-10 |
| AU2007315484A1 (en) | 2008-05-08 |
| AR063448A1 (es) | 2009-01-28 |
| EP2093236A1 (en) | 2009-08-26 |
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