CU23943B1 - Depsipéptidos cíclicos - Google Patents

Depsipéptidos cíclicos

Info

Publication number
CU23943B1
CU23943B1 CU2010000032A CU20100032A CU23943B1 CU 23943 B1 CU23943 B1 CU 23943B1 CU 2010000032 A CU2010000032 A CU 2010000032A CU 20100032 A CU20100032 A CU 20100032A CU 23943 B1 CU23943 B1 CU 23943B1
Authority
CU
Cuba
Prior art keywords
disease
diseases
depsypeptides
well
syndrome
Prior art date
Application number
CU2010000032A
Other languages
English (en)
Other versions
CU20100032A7 (es
Inventor
Philipp Krastel
Brigitta-Maria Liechty
Esther Schmitt
Erwin Paul Schreiner
Josef Gottfried Meingassner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38805728&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23943(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20100032A7 publication Critical patent/CU20100032A7/es
Publication of CU23943B1 publication Critical patent/CU23943B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente solicitud se refiere a depsipéptidos cíclicos, que tienen la estructura de la fórmula (I), activos como inhibidores de calicreína 7 y elastasa de neutrófilos humanos. Los depsipéptidos de la invención son útiles en la fabricación de medicamentos para el tratamiento de enfermedades de la piel, inflamatorias y/o proliferativas y pruríticas tales como queloides, escaras, hipertróficas, acné, dermatitis atópica, psoriasis, psoriasis pustular, rosácea, síndrome de Netherton u otras dermatosis pruríticas tales como prurigo nodularis, comezón no especificada de los ancianos, así como otras enfermedades con mal funcionamiento de la barrera epitelial tal como piel envejecida, enfermedad inflamatoria del intestino y enfermedad de Crohn, así como pancreatitis, o de cáncer, en particular cáncer de ovario, fibrosis cística (CF), enfermedad pulmonar obstructiva crónica (COPD), fibrosis pulmonar, síndrome de insuficiencia respiratoria de adultos, bronquitis crónica, efisema hereditario, artritis reumatoide, IBD, o asma.
CU2010000032A 2007-08-17 2010-02-17 Depsipéptidos cíclicos CU23943B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114507 2007-08-17
PCT/EP2008/060689 WO2009024527A1 (en) 2007-08-17 2008-08-14 Cyclic depsipeptides

Publications (2)

Publication Number Publication Date
CU20100032A7 CU20100032A7 (es) 2011-10-05
CU23943B1 true CU23943B1 (es) 2013-09-27

Family

ID=38805728

Family Applications (2)

Application Number Title Priority Date Filing Date
CU2010000032A CU23943B1 (es) 2007-08-17 2010-02-17 Depsipéptidos cíclicos
CU2013000063A CU20130063A7 (es) 2007-08-17 2013-05-02 Proceso de producción de depsipéptidos cíclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CU2013000063A CU20130063A7 (es) 2007-08-17 2013-05-02 Proceso de producción de depsipéptidos cíclicos

Country Status (30)

Country Link
US (2) US8178650B2 (es)
EP (1) EP2183273B1 (es)
JP (1) JP5520824B2 (es)
KR (2) KR101227231B1 (es)
CN (1) CN103298827B (es)
AR (1) AR068343A1 (es)
AU (1) AU2008290567B2 (es)
BR (1) BRPI0815547B8 (es)
CA (1) CA2696570C (es)
CL (1) CL2008002394A1 (es)
CO (1) CO6260099A2 (es)
CR (1) CR11251A (es)
CU (2) CU23943B1 (es)
EA (1) EA017735B1 (es)
EC (1) ECSP109968A (es)
ES (1) ES2632392T3 (es)
GT (1) GT201000037A (es)
MA (1) MA31701B1 (es)
MX (1) MX2010001849A (es)
MY (1) MY151973A (es)
NZ (1) NZ583284A (es)
PE (2) PE20141199A1 (es)
PL (1) PL2183273T3 (es)
PT (1) PT2183273T (es)
SV (1) SV2010003485A (es)
TN (1) TN2010000074A1 (es)
TW (1) TW200922613A (es)
UA (1) UA98658C2 (es)
WO (1) WO2009024527A1 (es)
ZA (1) ZA201000776B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009024528A1 (en) 2007-08-17 2009-02-26 Novartis Ag Use of cyclic depsipeptides to inhibit kallikrein 7
NZ583284A (en) 2007-08-17 2012-04-27 Novartis Ag Cyclic depsipeptides from isolated chondromyces crocatus useful as inhibitors of kallikrein 7 and human neutrophil elastase
AU2010212851B2 (en) * 2009-02-13 2012-12-13 Novartis Ag Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) * 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
PT3097084T (pt) 2014-01-23 2020-12-09 Sixera Pharma Ab Novos inibidores de calicreína 7
WO2015114144A1 (en) * 2014-02-03 2015-08-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of netherton syndrome
US20170022254A1 (en) 2014-04-08 2017-01-26 Novartis Ag Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
KR101729848B1 (ko) 2015-06-30 2017-04-24 영남대학교 산학협력단 신규한 해양 바실러스속 균주, 이로부터 분리한 화합물 및 상기 화합물의 약제학적 용도
CN106518880B (zh) * 2015-11-04 2018-10-19 衡阳师范学院 激肽释放酶7小分子抑制剂及其制备方法与用途
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
CN114423791B (zh) 2019-09-18 2026-01-09 豪夫迈·罗氏有限公司 抗klk7抗体、抗klk5抗体、多特异性抗klk5/klk7抗体及使用方法

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DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
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DE4421113A1 (de) * 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
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EP1716248A1 (en) * 2004-02-03 2006-11-02 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
CA2651796A1 (en) * 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
NZ583284A (en) 2007-08-17 2012-04-27 Novartis Ag Cyclic depsipeptides from isolated chondromyces crocatus useful as inhibitors of kallikrein 7 and human neutrophil elastase
WO2009024528A1 (en) 2007-08-17 2009-02-26 Novartis Ag Use of cyclic depsipeptides to inhibit kallikrein 7
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US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
KR20100044893A (ko) 2010-04-30
TW200922613A (en) 2009-06-01
CR11251A (es) 2010-03-08
PE20141199A1 (es) 2014-09-24
KR101227231B1 (ko) 2013-01-28
NZ583284A (en) 2012-04-27
US8178650B2 (en) 2012-05-15
CA2696570A1 (en) 2009-02-26
WO2009024527A1 (en) 2009-02-26
TN2010000074A1 (en) 2011-09-26
ZA201000776B (en) 2010-10-27
CL2008002394A1 (es) 2009-05-15
KR20120123579A (ko) 2012-11-08
CA2696570C (en) 2020-12-29
BRPI0815547B8 (pt) 2021-05-25
EA017735B1 (ru) 2013-02-28
UA98658C2 (uk) 2012-06-11
PT2183273T (pt) 2017-05-22
ECSP109968A (es) 2010-03-31
US9127044B2 (en) 2015-09-08
US20090156472A1 (en) 2009-06-18
PE20091007A1 (es) 2009-08-14
EP2183273B1 (en) 2017-04-05
CU20130063A7 (es) 2013-06-28
EA201000329A1 (ru) 2010-08-30
JP2010536731A (ja) 2010-12-02
MA31701B1 (fr) 2010-09-01
GT201000037A (es) 2012-04-30
BRPI0815547B1 (pt) 2020-09-15
US20120196790A1 (en) 2012-08-02
JP5520824B2 (ja) 2014-06-11
AU2008290567A1 (en) 2009-02-26
SV2010003485A (es) 2011-03-23
AR068343A1 (es) 2009-11-11
EP2183273A1 (en) 2010-05-12
CN103298827B (zh) 2017-05-31
PL2183273T3 (pl) 2017-09-29
ES2632392T3 (es) 2017-09-12
CO6260099A2 (es) 2011-03-22
MY151973A (en) 2014-07-31
AU2008290567B2 (en) 2011-05-12
BRPI0815547A2 (pt) 2015-02-10
CN103298827A (zh) 2013-09-11
MX2010001849A (es) 2010-03-10
CU20100032A7 (es) 2011-10-05

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