CU24493B1 - Complejo de torio dirigido a tejido - Google Patents

Complejo de torio dirigido a tejido

Info

Publication number
CU24493B1
CU24493B1 CU2017000082A CU20170082A CU24493B1 CU 24493 B1 CU24493 B1 CU 24493B1 CU 2017000082 A CU2017000082 A CU 2017000082A CU 20170082 A CU20170082 A CU 20170082A CU 24493 B1 CU24493 B1 CU 24493B1
Authority
CU
Cuba
Prior art keywords
complex
torio
tissue targeted
addition
tissue
Prior art date
Application number
CU2017000082A
Other languages
English (en)
Other versions
CU20170082A7 (es
Inventor
Alan Cuthbertson
Original Assignee
Bayer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54884033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24493(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer As filed Critical Bayer As
Publication of CU20170082A7 publication Critical patent/CU20170082A7/es
Publication of CU24493B1 publication Critical patent/CU24493B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/103—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for growth factors or receptors for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>La invención provee un complejo dirigido a tejido por acoplamiento de quelantes específicos a porciones de direccionamiento apropiadas, seguido por el agregado de un ión de torio emisor alfa. Además del complejo de torio, se proveen las formulaciones farmacéuticas correspondientes. La invención también se relaciona con la administración de estos complejos particularmente en enfermedades neoplásicas. </p>
CU2017000082A 2014-12-17 2015-12-15 Complejo de torio dirigido a tejido CU24493B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201422512 2014-12-17
PCT/EP2015/079773 WO2016096843A1 (en) 2014-12-17 2015-12-15 Radio-pharmaceutical complexes

Publications (2)

Publication Number Publication Date
CU20170082A7 CU20170082A7 (es) 2017-10-05
CU24493B1 true CU24493B1 (es) 2020-12-17

Family

ID=54884033

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2017000082A CU24493B1 (es) 2014-12-17 2015-12-15 Complejo de torio dirigido a tejido

Country Status (30)

Country Link
US (2) US20170340759A1 (es)
EP (1) EP3233137A1 (es)
JP (2) JP6821569B2 (es)
KR (1) KR20170094223A (es)
CN (1) CN107278155B (es)
AR (1) AR103063A1 (es)
AU (2) AU2015367722A1 (es)
BR (1) BR112017012841A2 (es)
CA (1) CA2970841A1 (es)
CL (1) CL2017001592A1 (es)
CO (1) CO2017005975A2 (es)
CR (1) CR20170256A (es)
CU (1) CU24493B1 (es)
DO (1) DOP2017000143A (es)
EA (1) EA201791350A9 (es)
EC (1) ECSP17038089A (es)
IL (1) IL252244B (es)
JO (1) JOP20150319B1 (es)
MA (1) MA41176A (es)
MX (1) MX384088B (es)
MY (1) MY194190A (es)
NI (1) NI201700076A (es)
PE (2) PE20171181A1 (es)
PH (1) PH12017501125A1 (es)
SG (1) SG11201704917XA (es)
TN (1) TN2017000255A1 (es)
TW (1) TWI654179B (es)
UA (1) UA125369C2 (es)
UY (1) UY36453A (es)
WO (1) WO2016096843A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201806548UA (en) * 2016-03-24 2018-08-30 Bayer Pharma AG Radio-pharmaceutical complexes
BR112018075554A2 (pt) * 2016-06-10 2019-10-01 Bayer As complexos radiofarmacêuticos
EP3585436A1 (en) 2017-02-24 2020-01-01 Bayer AS Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor
IL311111A (en) 2017-03-30 2024-04-01 Univ Cornell Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy for cancer
EP3843743A1 (en) 2018-08-28 2021-07-07 Bayer AS Combination of pi3k-inhibitors and targeted thorium conjugates
US20220125960A1 (en) 2019-02-21 2022-04-28 Bayer Aktiengesellschaft Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates
EP3927339A1 (en) 2019-02-22 2021-12-29 Bayer Aktiengesellschaft Combination of ar antagonists and targeted thorium conjugates
TW202116733A (zh) 2019-07-25 2021-05-01 挪威商拜耳公司 用於癌症診斷及治療之靶向放射性藥品
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
US20240108766A1 (en) 2021-01-22 2024-04-04 Bayer Aktiengesellschaft Lrrc15 antibodies and conjugates thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008085064A2 (en) * 2007-01-11 2008-07-17 Ge Healthcare As Hydroxypyridinone chelating agents, their metal complexes and their use as mri contrast agents
GB201002508D0 (en) * 2010-02-12 2010-03-31 Algeta As Product
GB201208309D0 (en) * 2012-05-11 2012-06-27 Algeta As Complexes

Also Published As

Publication number Publication date
EP3233137A1 (en) 2017-10-25
JP7160961B2 (ja) 2022-10-25
JP2018506513A (ja) 2018-03-08
CO2017005975A2 (es) 2017-11-30
US20170340759A1 (en) 2017-11-30
IL252244B (en) 2020-10-29
PE20230829A1 (es) 2023-05-19
TWI654179B (zh) 2019-03-21
NI201700076A (es) 2017-09-22
EA201791350A9 (ru) 2020-02-11
UY36453A (es) 2016-07-29
CA2970841A1 (en) 2016-06-23
WO2016096843A1 (en) 2016-06-23
MX2017008093A (es) 2018-02-09
SG11201704917XA (en) 2017-07-28
BR112017012841A2 (pt) 2018-04-10
CL2017001592A1 (es) 2018-03-16
MA41176A (fr) 2017-10-24
KR20170094223A (ko) 2017-08-17
DOP2017000143A (es) 2017-07-15
MX384088B (es) 2025-03-14
TW201627286A (zh) 2016-08-01
JP2021063108A (ja) 2021-04-22
AU2021202665A1 (en) 2021-05-27
TN2017000255A1 (en) 2018-10-19
UA125369C2 (uk) 2022-03-02
ECSP17038089A (es) 2017-07-31
CN107278155A (zh) 2017-10-20
PE20171181A1 (es) 2017-08-22
CR20170256A (es) 2017-08-11
AU2015367722A1 (en) 2017-06-08
IL252244A0 (en) 2017-07-31
CN107278155B (zh) 2021-03-30
AR103063A1 (es) 2017-04-12
CU20170082A7 (es) 2017-10-05
MY194190A (en) 2022-11-18
US20210322583A1 (en) 2021-10-21
JP6821569B2 (ja) 2021-01-27
AU2021202665B2 (en) 2023-04-27
EA201791350A1 (ru) 2017-12-29
PH12017501125A1 (en) 2017-11-27
JOP20150319B1 (ar) 2021-08-17

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