CU24645B1 - Una partícula retroviral recombinante incompetente para la replicación - Google Patents

Una partícula retroviral recombinante incompetente para la replicación

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Publication number
CU24645B1
CU24645B1 CU2019000075A CU20190075A CU24645B1 CU 24645 B1 CU24645 B1 CU 24645B1 CU 2019000075 A CU2019000075 A CU 2019000075A CU 20190075 A CU20190075 A CU 20190075A CU 24645 B1 CU24645 B1 CU 24645B1
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CU
Cuba
Prior art keywords
cells
replication
recombinant retroviral
incompetent
methods
Prior art date
Application number
CU2019000075A
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English (en)
Other versions
CU20190075A7 (es
Inventor
Gregory Ian Frost
Ghiabe H Guibinga
Farzad Haerizadeh
James Joseph Onuffer
Original Assignee
Exuma Biotech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/462,855 external-priority patent/US10596274B2/en
Priority claimed from PCT/US2017/041277 external-priority patent/WO2018009923A1/en
Priority claimed from US15/644,778 external-priority patent/US11111505B2/en
Application filed by Exuma Biotech Corp filed Critical Exuma Biotech Corp
Publication of CU20190075A7 publication Critical patent/CU20190075A7/es
Publication of CU24645B1 publication Critical patent/CU24645B1/es

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    • C12N15/1034—Isolating an individual clone by screening libraries
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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Abstract

<p>La presente descripción proporciona partículas retrovirales recombinantes incapaces de replicación para modificar genéticamente linfocitos y transducir células T y/o células NK. Las partículas retrovirales recombinantes incompetentes para la replicación pueden incluir polinucleótidos que codifican polipéptidos de señalización manipulados que pueden incluir un elemento linfoproliferativo y/o un receptor de antígeno quimérico (CAR). En el presente documento se proporcionan elementos adicionales de dichos polipéptidos de señalización modificados genéticamente, como los que impulsan la proliferación y los elementos reguladores de los mismos, así como las líneas célulares de empaquetamiento y los métodos para fabricarlas. Se proporcionan numerosos elementos y métodos para regular células T y/o las células NK transducidas y/o modificadas genéticamente, como, por ejemplo, las que incluyen dominios de reconocimiento o eliminación.</p>
CU2019000075A 2017-03-03 2018-03-03 Una partícula retroviral recombinante incompetente para la replicación CU24645B1 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762467039P 2017-03-03 2017-03-03
US15/462,855 US10596274B2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
PCT/US2017/023112 WO2017165245A2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
PCT/US2017/041277 WO2018009923A1 (en) 2016-07-08 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
US15/644,778 US11111505B2 (en) 2016-03-19 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
US201762560176P 2017-09-18 2017-09-18
US201762564253P 2017-09-27 2017-09-27
US201762564991P 2017-09-28 2017-09-28
PCT/US2018/020818 WO2018161064A1 (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Publications (2)

Publication Number Publication Date
CU20190075A7 CU20190075A7 (es) 2020-04-02
CU24645B1 true CU24645B1 (es) 2023-02-13

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EP (2) EP3589733B1 (es)
KR (2) KR102879522B1 (es)
CN (1) CN110892070A (es)
AU (2) AU2018226884B2 (es)
BR (1) BR112019018288A2 (es)
CA (1) CA3054064A1 (es)
CU (1) CU24645B1 (es)
IL (1) IL268739B2 (es)
MX (1) MX2019010445A (es)
SG (2) SG11201907814SA (es)
TW (1) TWI905076B (es)
WO (1) WO2018161064A1 (es)

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US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
CN108884460B (zh) * 2016-03-19 2023-04-28 埃克苏马生物技术公司 淋巴细胞转导及其扩增调节的方法与组合物
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
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EP3715368A1 (en) * 2019-03-28 2020-09-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells
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BR112022003553A2 (pt) 2019-08-30 2022-05-24 Allogene Therapeutics Inc Receptores de citocina quiméricos compreendendo domínios de ligação a tgf beta
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