CU24660B1 - Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197 - Google Patents

Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197

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Publication number
CU24660B1
CU24660B1 CU2019000030A CU20190030A CU24660B1 CU 24660 B1 CU24660 B1 CU 24660B1 CU 2019000030 A CU2019000030 A CU 2019000030A CU 20190030 A CU20190030 A CU 20190030A CU 24660 B1 CU24660 B1 CU 24660B1
Authority
CU
Cuba
Prior art keywords
vaccine compositions
psaa
streptococcus pneumoniae
carrier proteins
polysaccharide
Prior art date
Application number
CU2019000030A
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English (en)
Other versions
CU20190030A7 (es
Inventor
Rajendar Burki
Deviprasanna Chakka
Mahima Datla
Sreenivasa Ganti
Narender Mantena
Ramesh Matur
Rajan Sriraman
Satyam Sureddi
Original Assignee
Biological E Ltd
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Publication date
Application filed by Biological E Ltd filed Critical Biological E Ltd
Publication of CU20190030A7 publication Critical patent/CU20190030A7/es
Publication of CU24660B1 publication Critical patent/CU24660B1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>La presente descripción se refiere a composiciones de vacunas antineumocócicas multivalentes, como las de Streptococcus pneumoniae, que comprenden serotipos de polisacáridos neumocócicos capsulares, cada uno de ellos conjugado individualmente con proteínas transportadoras, como PsaA y CRM197, para una respuesta inmunitaria mejorada. Cuando se conjuga, Ia combinación del serotipo de polisacárido neumocócico capsular y Ia proteína portadora se denomina aquí conjugado de polisacárido-proteína. Las composiciones de vacuna neumocócica pueden comprender además uno o más de los siguientes; un vehículo farmacéuticamente aceptable, un diluyente farmacéuticamente aceptable, un tampón, un conservante, un estabilizador, un adyuvante y/o un excipiente de liofilización. También se proporcionan métodos para preparar y administrar las composiciones de vacunas neumocócica descritas en el presente documento.</p>
CU2019000030A 2016-09-30 2017-09-29 Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197 CU24660B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641033563 2016-09-30
PCT/US2017/054237 WO2018064444A1 (en) 2016-09-30 2017-09-29 Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates

Publications (2)

Publication Number Publication Date
CU20190030A7 CU20190030A7 (es) 2019-11-04
CU24660B1 true CU24660B1 (es) 2023-05-11

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Family Applications (1)

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CU2019000030A CU24660B1 (es) 2016-09-30 2017-09-29 Composiciones de vacunas multivalentes que comprenden conjugados de polisacárido-proteína de streptococcus pneumoniae utilizando proteínas portadoras psaa y crm197

Country Status (21)

Country Link
US (1) US11547752B2 (es)
EP (1) EP3518965A1 (es)
JP (2) JP2019529497A (es)
KR (1) KR102608081B1 (es)
CN (1) CN109789198B (es)
AU (1) AU2017336806B2 (es)
BR (1) BR112019006278A2 (es)
CA (1) CA3037056A1 (es)
CL (1) CL2019000849A1 (es)
CO (1) CO2019002955A2 (es)
CU (1) CU24660B1 (es)
EA (1) EA201990838A1 (es)
IL (2) IL297575B2 (es)
MX (1) MX2019003593A (es)
MY (1) MY204888A (es)
NZ (1) NZ752348A (es)
PH (1) PH12019500672B1 (es)
SA (1) SA519401317B1 (es)
UA (1) UA126385C2 (es)
WO (1) WO2018064444A1 (es)
ZA (1) ZA201901170B (es)

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NZ792866A (en) 2025-10-31
NZ752348A (en) 2022-11-25
SA519401317B1 (ar) 2023-11-14
IL297575B2 (en) 2023-12-01
CN109789198B (zh) 2024-08-16
PH12019500672B1 (en) 2024-02-23
JP2019529497A (ja) 2019-10-17
CO2019002955A2 (es) 2019-06-11
EP3518965A1 (en) 2019-08-07
CL2019000849A1 (es) 2019-09-23
AU2017336806A1 (en) 2019-05-02
IL297575B1 (en) 2023-08-01
US20190224295A1 (en) 2019-07-25
MY204888A (en) 2024-09-20
CN109789198A (zh) 2019-05-21
UA126385C2 (uk) 2022-09-28
PH12019500672A1 (en) 2019-07-29
ZA201901170B (en) 2024-08-28
CA3037056A1 (en) 2018-04-05
IL265623B2 (en) 2023-04-01
EA201990838A1 (ru) 2019-08-30
CU20190030A7 (es) 2019-11-04
KR102608081B1 (ko) 2023-11-29
KR20190066032A (ko) 2019-06-12
AU2017336806B2 (en) 2024-06-27
IL297575A (en) 2022-12-01
IL265623B (en) 2022-12-01
JP7403576B2 (ja) 2023-12-22
US11547752B2 (en) 2023-01-10
JP2022105155A (ja) 2022-07-12
WO2018064444A1 (en) 2018-04-05
AU2017336806A8 (en) 2019-05-16
MX2019003593A (es) 2019-06-10
IL265623A (en) 2019-05-30
BR112019006278A2 (pt) 2019-07-02

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