CU24713B1 - Compuestos aromáticos bicíclicos derivatizados por ácido fenilacético y bencilamina, útiles en el tratamiento de trastornos inmunológicos, enfermedades del sistema nervioso central, neurodegenerativas, renales y cardiovasculares - Google Patents

Compuestos aromáticos bicíclicos derivatizados por ácido fenilacético y bencilamina, útiles en el tratamiento de trastornos inmunológicos, enfermedades del sistema nervioso central, neurodegenerativas, renales y cardiovasculares

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CU24713B1
CU24713B1 CU2022000024A CU20220024A CU24713B1 CU 24713 B1 CU24713 B1 CU 24713B1 CU 2022000024 A CU2022000024 A CU 2022000024A CU 20220024 A CU20220024 A CU 20220024A CU 24713 B1 CU24713 B1 CU 24713B1
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CU
Cuba
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neurodegenerative
renal
useful
treatment
aromatic compounds
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CU2022000024A
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English (en)
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CU20220024A7 (es
Inventor
Yarlagadda Babu
zhao Dang
Pravin Kotian
peng-cheng Lu
Wei Lv
Krishnan Raman
Andrew Spaulding
Weihe Zhang
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Biocryst Pharm Inc
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Publication of CU20220024A7 publication Critical patent/CU20220024A7/es
Publication of CU24713B1 publication Critical patent/CU24713B1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

<p>La presente invención se refiere a compuestos aromáticos bicíclicos de la fórmula (I)</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>y sales farmacéuticamente aceptables de los mismos, que son inhibidores de la actividad enzimática del Factor D, útiles en el tratamiento o la prevención de enfermedades o afecciones que presentan una actividad aberrante del sistema del complemento, enfermedades del sistema inmunológico, nervioso, renal, cardiovascular, hematológico, ocular u ocular, neurodegenerativas o neurológicas.</p>
CU2022000024A 2019-10-09 2020-10-09 Compuestos aromáticos bicíclicos derivatizados por ácido fenilacético y bencilamina, útiles en el tratamiento de trastornos inmunológicos, enfermedades del sistema nervioso central, neurodegenerativas, renales y cardiovasculares CU24713B1 (es)

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US201962912929P 2019-10-09 2019-10-09
PCT/US2020/054992 WO2021072198A1 (en) 2019-10-09 2020-10-09 Oral complement factor d inhibitors

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