CU34028A - PROCEDURE TO ISOLATE VINBLASTINE AND LEUROSIN FROM VICARIA - Google Patents
PROCEDURE TO ISOLATE VINBLASTINE AND LEUROSIN FROM VICARIAInfo
- Publication number
- CU34028A CU34028A CU34028A CU34028A CU34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A
- Authority
- CU
- Cuba
- Prior art keywords
- vinblastine
- vicaria
- leurosin
- isolate
- procedure
- Prior art date
Links
- LPGWZGMPDKDHEP-GKWAKPNHSA-N Leurosine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@]6(CC)O[C@@H]6[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C LPGWZGMPDKDHEP-GKWAKPNHSA-N 0.000 title abstract 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title abstract 2
- 229960003048 vinblastine Drugs 0.000 title abstract 2
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 abstract 2
- LPGWZGMPDKDHEP-HLTPFJCJSA-N Leurosine Chemical compound C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC LPGWZGMPDKDHEP-HLTPFJCJSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
El extracto de alcaloides totales de la planta se prepara amonizando el material disponible y extrayendo con benceno. Con posterioridad se purifica extrayendo con ácido, basificando y pasando éstos a éter etílico. Esta fracción total se subdivide en otras a diferentes pH selectivizandose la vinblastina y la leurosina mediante el ácido tiociánico y una purificación final por cromatografía en Alúmina.The total alkaloid extract of the plant is prepared by ammoniating the available material and extracting with benzene. Subsequently it is purified by extracting with acid, basifying and passing these to ethyl ether. This total fraction is subdivided into others at different pH, vinblastine and leurosine being selectivized by thiocyanic acid and a final purification by alumina chromatography.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU34028A CU34028A (en) | 1974-03-02 | 1974-03-02 | PROCEDURE TO ISOLATE VINBLASTINE AND LEUROSIN FROM VICARIA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU34028A CU34028A (en) | 1974-03-02 | 1974-03-02 | PROCEDURE TO ISOLATE VINBLASTINE AND LEUROSIN FROM VICARIA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU34028A true CU34028A (en) | 1980-01-24 |
Family
ID=41087221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU34028A CU34028A (en) | 1974-03-02 | 1974-03-02 | PROCEDURE TO ISOLATE VINBLASTINE AND LEUROSIN FROM VICARIA |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU34028A (en) |
-
1974
- 1974-03-02 CU CU34028A patent/CU34028A/en unknown
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