CU34028A - Procedimiento para aislar vinblastina y leurosina de vicaria - Google Patents
Procedimiento para aislar vinblastina y leurosina de vicariaInfo
- Publication number
- CU34028A CU34028A CU34028A CU34028A CU34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A CU 34028 A CU34028 A CU 34028A
- Authority
- CU
- Cuba
- Prior art keywords
- vinblastine
- vicaria
- leurosin
- isolate
- procedure
- Prior art date
Links
- LPGWZGMPDKDHEP-GKWAKPNHSA-N Leurosine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@]6(CC)O[C@@H]6[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C LPGWZGMPDKDHEP-GKWAKPNHSA-N 0.000 title abstract 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title abstract 2
- 229960003048 vinblastine Drugs 0.000 title abstract 2
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 abstract 2
- LPGWZGMPDKDHEP-HLTPFJCJSA-N Leurosine Chemical compound C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC LPGWZGMPDKDHEP-HLTPFJCJSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
El extracto de alcaloides totales de la planta se prepara amonizando el material disponible y extrayendo con benceno. Con posterioridad se purifica extrayendo con ácido, basificando y pasando éstos a éter etílico. Esta fracción total se subdivide en otras a diferentes pH selectivizandose la vinblastina y la leurosina mediante el ácido tiociánico y una purificación final por cromatografía en Alúmina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU34028A CU34028A (es) | 1974-03-02 | 1974-03-02 | Procedimiento para aislar vinblastina y leurosina de vicaria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU34028A CU34028A (es) | 1974-03-02 | 1974-03-02 | Procedimiento para aislar vinblastina y leurosina de vicaria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU34028A true CU34028A (es) | 1980-01-24 |
Family
ID=41087221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU34028A CU34028A (es) | 1974-03-02 | 1974-03-02 | Procedimiento para aislar vinblastina y leurosina de vicaria |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU34028A (es) |
-
1974
- 1974-03-02 CU CU34028A patent/CU34028A/es unknown
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