CY1124237T1 - Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη - Google Patents

Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη

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Publication number
CY1124237T1
CY1124237T1 CY20211100001T CY211100001T CY1124237T1 CY 1124237 T1 CY1124237 T1 CY 1124237T1 CY 20211100001 T CY20211100001 T CY 20211100001T CY 211100001 T CY211100001 T CY 211100001T CY 1124237 T1 CY1124237 T1 CY 1124237T1
Authority
CY
Cyprus
Prior art keywords
tyrosine
neurotoxin
tryptophane
liquid preparation
tryptophan
Prior art date
Application number
CY20211100001T
Other languages
English (en)
Inventor
Anders Jarstad
Anna FRIIS
Ulf Stahl
Ann GURELL
Barbro AGREN
Emilia EDSTROM
Andrew Pickett
Original Assignee
Ipsen Biopharm Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Biopharm Limited filed Critical Ipsen Biopharm Limited
Publication of CY1124237T1 publication Critical patent/CY1124237T1/el

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    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά σε σταθερά υγρά σκευάσματα νευροτοξίνης που είναι άνευ ζωικών πρωτεϊνών, που περιλαμβάνουν επιφανειοδραστικό, αμινοξύ που επιλέγεται από τρυπτοφάνη και τυροσίνη, ρυθμιστικό που περιλαμβάνει νατρίου, χλωριούχου και φωσφορικού ιόντα, που έχει pΗ μεταξύ 5,5 και 8, και που είναι σταθερά για 2 μήνες. Αυτές οι συνθέσεις είναι κατάλληλες για χρήση στη θεραπεία και ιδιαιτέρως για χορήγηση σε έναν ασθενή για να επιτευχθεί επιθυμητό θεραπευτικό ή αισθητικό αποτέλεσμα. Η εφεύρεση επίσης αφορά στη χρήση ενός αμινοξέος που επιλέγεται από τρυπτοφάνη και τυροσίνη για να προστατεύει πρωτεϊνώδη νευροτοξίνη από αποικοδόμηση σε υγρή σύνθεση η οποία είναι ελεύθερη ζωικά λαμβανόμενων πρωτεϊνών.
CY20211100001T 2016-05-27 2021-01-05 Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη CY1124237T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016062085 2016-05-27
PCT/EP2017/062785 WO2017203038A1 (en) 2016-05-27 2017-05-26 Liquid neurotoxin formulation stabilized with tryptophan or tyrosine

Publications (1)

Publication Number Publication Date
CY1124237T1 true CY1124237T1 (el) 2022-07-22

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CY20211100001T CY1124237T1 (el) 2016-05-27 2021-01-05 Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη
CY20221100057T CY1124916T1 (el) 2016-05-27 2022-01-25 Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη

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US (5) US20190183988A1 (el)
EP (3) EP3679946B1 (el)
JP (1) JP7053498B2 (el)
KR (2) KR102399451B1 (el)
CN (2) CN109562148A (el)
AR (1) AR108631A1 (el)
AU (1) AU2017270359B2 (el)
CA (1) CA3025437A1 (el)
CY (2) CY1124237T1 (el)
DK (3) DK3679946T3 (el)
EA (1) EA038124B1 (el)
ES (3) ES3062544T3 (el)
FI (1) FI4026532T3 (el)
GE (2) GEAP202014939A (el)
HR (3) HRP20251606T1 (el)
HU (2) HUE057640T2 (el)
IL (2) IL285190B (el)
LT (3) LT3679946T (el)
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NZ (1) NZ788585A (el)
PL (3) PL3463432T3 (el)
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SA (1) SA518400513B1 (el)
SG (1) SG11201810561YA (el)
SI (3) SI3463432T1 (el)
SM (3) SMT202100003T1 (el)
TW (1) TWI777955B (el)
UA (1) UA123679C2 (el)
WO (1) WO2017203038A1 (el)
ZA (1) ZA201807904B (el)

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IL268980B (en) 2009-06-25 2022-09-01 Revance Therapeutics Inc Albumin-free botulinum toxin formulations
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
KR102480965B1 (ko) 2016-09-13 2022-12-26 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
AU2018389104A1 (en) * 2017-12-20 2020-07-30 Allergan, Inc. Botulinum toxin cell binding domain polypeptides and methods of use for skin rejuvenation
TW202112348A (zh) * 2019-06-07 2021-04-01 英商益普生生物製藥有限公司 中度至極重度眉間紋及眼角外紋之治療
CN115397399B (zh) * 2020-04-08 2025-06-27 玫帝托克斯股份有限公司 一种易于控制排出速度且稳定的肉毒杆菌毒素预填充式注射器剂型
CN116440281A (zh) * 2022-01-07 2023-07-18 重庆誉颜制药有限公司 一种肉毒毒素蛋白组合物
WO2023135428A1 (en) * 2022-01-14 2023-07-20 Galderma Holding SA Treatment of moderate to very severe glabellar lines and lateral canthal lines
IL315004A (en) 2022-02-15 2024-10-01 Merz Pharma Gmbh & Co Kgaa : Liquid botulinum toxin formulation and its uses
IL326140A (en) 2023-08-10 2026-03-01 Merz Pharma Gmbh & Co Kgaa Liquid formulation of botulinum toxin and its use

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