CY1124366T1 - Μεθοδοι αυξησης τονικης αναστολης και θεραπειας της δευτερογενους αϋπνιας - Google Patents
Μεθοδοι αυξησης τονικης αναστολης και θεραπειας της δευτερογενους αϋπνιαςInfo
- Publication number
- CY1124366T1 CY1124366T1 CY20211100509T CY211100509T CY1124366T1 CY 1124366 T1 CY1124366 T1 CY 1124366T1 CY 20211100509 T CY20211100509 T CY 20211100509T CY 211100509 T CY211100509 T CY 211100509T CY 1124366 T1 CY1124366 T1 CY 1124366T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sleep
- subject
- increasing
- methods
- reduction
- Prior art date
Links
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title abstract 3
- 230000009478 tonic inhibition Effects 0.000 title abstract 3
- 230000007958 sleep Effects 0.000 abstract 7
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 230000037046 slow wave activity Effects 0.000 abstract 2
- 230000037322 slow-wave sleep Effects 0.000 abstract 2
- ZDZDSZQYRBZPNN-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate;hydrochloride Chemical compound Cl.C1NCCC2=C1ONC2=O ZDZDSZQYRBZPNN-UHFFFAOYSA-N 0.000 abstract 1
- 208000009575 Angelman syndrome Diseases 0.000 abstract 1
- 208000001914 Fragile X syndrome Diseases 0.000 abstract 1
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004622 sleep time Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
Δημοσιεύονται μέθοδοι αύξησης της τονικής αναστολής σε ένα υποκείμενο που το έχει ανάγκη, για παράδειγμα ένα υποκείμενο με σύνδρομο Fragile Χ ή σύνδρομο Angelman. Δημοσιεύονται επίσης μέθοδοι θεραπείας δευτερογενούς αϋπνίας σε ένα υποκείμενο με νευροεκφυλιστική νόσο ή διαταραχή. Οι μέθοδοι μπορούν να περιλαμβάνουν τη χορήγηση στο υποκείμενο μιας αποτελεσματικής ποσότητας 4,5,6,7-τετραϋδροϊσοξαζολο(5,4-c)πυριδιν-3-όλης (ΤΗΙΡ) ή ενός παραγώγου αυτής ή ενός φαρμακευτικώς αποδεκτού άλατος αυτής, την αύξηση της τονικής αναστολής στους νευρώνες του υποκειμένου• για την αύξηση του ύπνου με αργό κύμα (SWS) και/ή της δραστηριότητας αργού κύματος (SWA), την ομαλοποίηση της αρχιτεκτονικής του ύπνου, τη μείωση της δευτερογενούς αϋπνίας, την αύξηση του ύπνου μη ταχείας κίνησης των ματιών (NREM), την αύξηση της συνέχειας του ύπνου, τη βελτίωση της δραστηριότητας δέλτα στην NREM, την αύξηση ή τη βελτίωση του συνολικού χρόνου του ύπνου (TST), την αύξηση ή τη βελτίωση της αποτελεσματικότητας του ύπνου, τη μείωση του συνολικού χρόνου αφύπνισης (ΤΑΑ), τη μείωση του αριθμού αφυπνίσεων (NWA), τη μείωση της καθυστέρησης στον επίμονο ύπνο (LPS) ή τη μείωση της αφύπνισης μετά την έναρξη του ύπνου (WASO), στο υποκείμενο ή οποιονδήποτε συνδυασμό αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462008939P | 2014-06-06 | 2014-06-06 | |
| PCT/US2015/034018 WO2015187851A1 (en) | 2014-06-06 | 2015-06-03 | Methods of increasing tonic inhibition and treating secondary insomnia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124366T1 true CY1124366T1 (el) | 2022-07-22 |
Family
ID=54767324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100509T CY1124366T1 (el) | 2014-06-06 | 2021-06-10 | Μεθοδοι αυξησης τονικης αναστολης και θεραπειας της δευτερογενους αϋπνιας |
| CY20211100510T CY1124368T1 (el) | 2014-06-06 | 2021-06-10 | Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100510T CY1124368T1 (el) | 2014-06-06 | 2021-06-10 | Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman |
Country Status (20)
| Country | Link |
|---|---|
| US (11) | US20150352085A1 (el) |
| EP (3) | EP3372229B1 (el) |
| JP (4) | JP2017516868A (el) |
| AR (1) | AR100772A1 (el) |
| AU (4) | AU2015269667B2 (el) |
| CA (1) | CA2950845C (el) |
| CY (2) | CY1124366T1 (el) |
| DK (2) | DK3151832T3 (el) |
| ES (2) | ES2876350T3 (el) |
| HR (2) | HRP20210901T1 (el) |
| HU (2) | HUE055400T2 (el) |
| IL (2) | IL249287B (el) |
| LT (2) | LT3372229T (el) |
| MX (2) | MX391502B (el) |
| PL (2) | PL3372229T3 (el) |
| PT (2) | PT3372229T (el) |
| RS (2) | RS62006B1 (el) |
| SI (2) | SI3372229T1 (el) |
| SM (2) | SMT202100340T1 (el) |
| WO (1) | WO2015187851A1 (el) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6634626B2 (ja) | 2013-11-05 | 2020-01-22 | エレーナ モロカノヴァＥｌｅｎａ ＭＯＬＯＫＡＮＯＶＡ | 受容体およびイオンチャネルの位置特異的サブタイプの調節のためのナノ構造物複合体 |
| ES2876350T3 (es) | 2014-06-06 | 2021-11-12 | Ovid Therapeutics Inc | Métodos para aumentar la inhibición tónica y tratamiento del insomnio secundario |
| US10080898B2 (en) | 2015-05-29 | 2018-09-25 | Medtronic, Inc. | Simultaneous physiological sensing and stimulation with saturation detection |
| US10434308B2 (en) | 2015-05-29 | 2019-10-08 | Medtronic, Inc. | Impedance matching and electrode conditioning in patient interface systems |
| US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
| KR20240160666A (ko) | 2015-07-17 | 2024-11-11 | 오비드 테라퓨틱스 인크. | 가복사돌로 발달장애들을 치료하는 방법들 |
| WO2018017639A1 (en) * | 2016-07-19 | 2018-01-25 | Georgia State University Research Foundation | Methods for treating rett syndrome |
| EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
| JP2019535760A (ja) * | 2016-11-22 | 2019-12-12 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | フルピルチンを用いた発達障害および／または発作性障害の処置方法 |
| US10071083B2 (en) * | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
| US10813918B2 (en) | 2017-08-04 | 2020-10-27 | Ovid Therapeutics Inc. | Use of Gaboxadol in the treatment of diabetes and related conditions |
| US11181384B2 (en) * | 2018-07-23 | 2021-11-23 | Waymo Llc | Verifying map data using challenge questions |
| AU2019345312A1 (en) | 2018-09-20 | 2021-03-25 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering |
| WO2020106927A1 (en) * | 2018-11-21 | 2020-05-28 | Certego Therapeutics | Gaboxadol for reducing risk of suicide and rapid relief of depression |
| CN113423399A (zh) | 2018-12-17 | 2021-09-21 | 奥维德医疗公司 | 加波沙朵用于治疗非24小时睡眠-觉醒障碍的用途 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| KR20220035195A (ko) * | 2019-07-15 | 2022-03-21 | 오비드 테라퓨틱스 인크. | 치료적 치료를 위한 가복사돌을 포함하는 약학적 제제 |
| WO2021127308A1 (en) * | 2019-12-18 | 2021-06-24 | Ovid Therapeutics Inc. | GABOXADOL FOR THERAPEUTIC TREATMENT OF 1p36 DELETION SYNDROME |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
| JP7600661B2 (ja) * | 2020-12-11 | 2024-12-17 | ａｒｔｉｅｎｃｅ株式会社 | 貼付剤 |
| JP2026506097A (ja) * | 2023-02-17 | 2026-02-20 | オービッド・セラピューティクス・インコーポレイテッド | 多発性硬化症の処置における（ｓ）－３－アミノ－４－（ジフルオロメチレニル）シクロペント－１－エン－１－カルボン酸の使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DK270278A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
| DE19525598C2 (de) * | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| DE19526864A1 (de) | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
| US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| US6676961B1 (en) | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
| US20050137222A1 (en) * | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
| US20080269278A1 (en) | 2004-04-02 | 2008-10-30 | H. Lundbeck A/S | Treatment of Impaired Respiratory Function with Gaboxadol |
| DE102005020882A1 (de) * | 2005-05-04 | 2006-11-09 | Dömling, Alexander, Dr. | Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten |
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| CA2705733C (en) | 2007-11-13 | 2015-02-03 | Cadence Pharmaceuticals | Reduced dose intravenous acetaminophen |
| CA2732636A1 (en) * | 2008-09-01 | 2009-05-07 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of pat1 or oat |
| ES2876350T3 (es) | 2014-06-06 | 2021-11-12 | Ovid Therapeutics Inc | Métodos para aumentar la inhibición tónica y tratamiento del insomnio secundario |
| KR20240160666A (ko) * | 2015-07-17 | 2024-11-11 | 오비드 테라퓨틱스 인크. | 가복사돌로 발달장애들을 치료하는 방법들 |
| US9399034B1 (en) | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
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2015
- 2015-06-03 ES ES15803364T patent/ES2876350T3/es active Active
- 2015-06-03 MX MX2020012404A patent/MX391502B/es unknown
- 2015-06-03 JP JP2017516256A patent/JP2017516868A/ja not_active Withdrawn
- 2015-06-03 PL PL18169211T patent/PL3372229T3/pl unknown
- 2015-06-03 SM SM20210340T patent/SMT202100340T1/it unknown
- 2015-06-03 EP EP18169211.2A patent/EP3372229B1/en active Active
- 2015-06-03 AU AU2015269667A patent/AU2015269667B2/en active Active
- 2015-06-03 HU HUE18169211A patent/HUE055400T2/hu unknown
- 2015-06-03 SI SI201531620T patent/SI3372229T1/sl unknown
- 2015-06-03 US US14/729,910 patent/US20150352085A1/en not_active Abandoned
- 2015-06-03 PL PL15803364T patent/PL3151832T3/pl unknown
- 2015-06-03 DK DK15803364.7T patent/DK3151832T3/da active
- 2015-06-03 SI SI201531616T patent/SI3151832T1/sl unknown
- 2015-06-03 RS RS20210711A patent/RS62006B1/sr unknown
- 2015-06-03 LT LTEP18169211.2T patent/LT3372229T/lt unknown
- 2015-06-03 PT PT181692112T patent/PT3372229T/pt unknown
- 2015-06-03 ES ES18169211T patent/ES2875742T3/es active Active
- 2015-06-03 HU HUE15803364A patent/HUE055155T2/hu unknown
- 2015-06-03 EP EP15803364.7A patent/EP3151832B1/en active Active
- 2015-06-03 WO PCT/US2015/034018 patent/WO2015187851A1/en not_active Ceased
- 2015-06-03 MX MX2016016136A patent/MX380868B/es unknown
- 2015-06-03 HR HRP20210901TT patent/HRP20210901T1/hr unknown
- 2015-06-03 EP EP20204995.3A patent/EP3795156A1/en active Pending
- 2015-06-03 DK DK18169211.2T patent/DK3372229T3/da active
- 2015-06-03 CA CA2950845A patent/CA2950845C/en active Active
- 2015-06-03 RS RS20210718A patent/RS62007B1/sr unknown
- 2015-06-03 SM SM20210343T patent/SMT202100343T1/it unknown
- 2015-06-03 PT PT158033647T patent/PT3151832T/pt unknown
- 2015-06-03 LT LTEP15803364.7T patent/LT3151832T/lt unknown
- 2015-06-05 AR ARP150101808A patent/AR100772A1/es not_active Application Discontinuation
- 2015-10-19 US US14/886,764 patent/US9339495B2/en active Active
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2016
- 2016-04-19 US US15/132,641 patent/US9446028B2/en active Active
- 2016-11-04 US US15/343,690 patent/US9744159B2/en active Active
- 2016-11-29 IL IL249287A patent/IL249287B/en active IP Right Grant
- 2016-12-12 US US15/375,735 patent/US9801864B2/en active Active
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2017
- 2017-06-09 US US15/618,736 patent/US20170273956A1/en not_active Abandoned
- 2017-09-27 US US15/716,726 patent/US20180015076A1/en not_active Abandoned
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2018
- 2018-06-29 US US16/023,282 patent/US11278529B2/en active Active
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2019
- 2019-08-27 IL IL268960A patent/IL268960B/en active IP Right Grant
- 2019-11-29 JP JP2019217208A patent/JP2020063264A/ja not_active Withdrawn
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2020
- 2020-08-11 AU AU2020217342A patent/AU2020217342B2/en active Active
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2021
- 2021-06-07 HR HRP20210902TT patent/HRP20210902T1/hr unknown
- 2021-06-10 CY CY20211100509T patent/CY1124366T1/el unknown
- 2021-06-10 CY CY20211100510T patent/CY1124368T1/el unknown
- 2021-07-15 JP JP2021116935A patent/JP2021178836A/ja not_active Withdrawn
- 2021-09-30 US US17/490,650 patent/US20220016091A1/en not_active Abandoned
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2022
- 2022-01-07 AU AU2022200085A patent/AU2022200085A1/en not_active Abandoned
- 2022-08-08 US US17/882,939 patent/US20230051859A1/en not_active Abandoned
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2023
- 2023-05-30 JP JP2023088456A patent/JP2023123442A/ja active Pending
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2024
- 2024-04-22 AU AU2024202604A patent/AU2024202604A1/en active Pending
- 2024-10-03 US US18/905,678 patent/US20250025448A1/en active Pending
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