CY1124879T1 - Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου - Google Patents

Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου

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Publication number
CY1124879T1
CY1124879T1 CY20211101131T CY211101131T CY1124879T1 CY 1124879 T1 CY1124879 T1 CY 1124879T1 CY 20211101131 T CY20211101131 T CY 20211101131T CY 211101131 T CY211101131 T CY 211101131T CY 1124879 T1 CY1124879 T1 CY 1124879T1
Authority
CY
Cyprus
Prior art keywords
farsenyl
treatment
methods
cancer patients
transfer inhibitors
Prior art date
Application number
CY20211101131T
Other languages
English (en)
Inventor
Antonio Gualberto
Catherine Rose SCHOLZ
Original Assignee
Kura Oncology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kura Oncology, Inc. filed Critical Kura Oncology, Inc.
Publication of CY1124879T1 publication Critical patent/CY1124879T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Παρέχεται εις το παρόν ένας αναστολέας φαρνεσυλτρανσφεράσης (FTI) για χρήση σε μία μέθοδο αγωγής καρκινώματος πλακωδών κυττάρων κεφαλής και τραχήλου (HNSCC) σε έναν άνθρωπο, όπου ο εν λόγω άνθρωπος έχει μία μετάλλαξη H-Ras, και όπου το εν λόγω HNSCC είναι σε ένα προχωρημένο στάδιο, μεταστατικό, υποτροπιάζον, επανεμφανιζόμενο ή δυσάγωγο. Περαιτέρω παρέχονται εις το παρόν κατάλληλα σχήματα χορήγησης δοσολογιών για την λόγω χρήση και εν λόγω χρήση σε θεραπεία συνδυασμού.
CY20211101131T 2015-08-17 2021-12-23 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου CY1124879T1 (el)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562206194P 2015-08-17 2015-08-17
US201562218927P 2015-09-15 2015-09-15
US201562241019P 2015-10-13 2015-10-13
US201662310582P 2016-03-18 2016-03-18
US201662372662P 2016-08-09 2016-08-09
PCT/US2016/047140 WO2017031101A1 (en) 2015-08-17 2016-08-16 Methods of treating cancer patients with farnesyl transferase inhibitors
EP16757791.5A EP3277842B9 (en) 2015-08-17 2016-08-16 Methods of treating cancer patients with farnesyl transferase inhibitors
EP18173134.0A EP3385395B9 (en) 2015-08-17 2016-08-16 Methods of treating cancer patients with farnesyl transferase inhibitors

Publications (1)

Publication Number Publication Date
CY1124879T1 true CY1124879T1 (el) 2022-11-25

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CY20191100966T CY1122037T1 (el) 2015-08-17 2019-09-16 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου
CY20201100379T CY1123067T1 (el) 2015-08-17 2020-04-27 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου
CY20211101131T CY1124879T1 (el) 2015-08-17 2021-12-23 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου

Family Applications Before (2)

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CY20191100966T CY1122037T1 (el) 2015-08-17 2019-09-16 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου
CY20201100379T CY1123067T1 (el) 2015-08-17 2020-04-27 Μεθοδοι αγωγης ασθενων καρκινων με αναστολεις τρανσφερασης φαρνεσυλιου

Country Status (28)

Country Link
US (7) US10471055B2 (el)
EP (4) EP3995589A1 (el)
JP (4) JP6630742B2 (el)
KR (4) KR20210048600A (el)
CN (5) CN114107497A (el)
AU (3) AU2016308564B2 (el)
CA (1) CA2985123C (el)
CY (3) CY1122037T1 (el)
DK (3) DK3277842T5 (el)
EA (1) EA201890512A1 (el)
ES (3) ES2741782T3 (el)
HR (3) HRP20191424T2 (el)
HU (3) HUE044698T2 (el)
IL (1) IL257547B (el)
LT (3) LT3277842T (el)
MX (1) MX2018001769A (el)
MY (1) MY195484A (el)
NZ (1) NZ736853A (el)
PH (1) PH12018500322A1 (el)
PL (3) PL3385395T3 (el)
PT (3) PT3385395T (el)
RS (3) RS59158B9 (el)
SG (1) SG10202101740QA (el)
SI (3) SI3277842T1 (el)
SM (3) SMT202100712T1 (el)
TW (3) TWI710642B (el)
WO (1) WO2017031101A1 (el)
ZA (2) ZA201801047B (el)

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CN111097039B (zh) * 2020-01-16 2020-11-06 南京医科大学 Ras相关蛋白2的制药用途
CN111088349B (zh) * 2020-02-14 2023-04-28 深圳市宝安区妇幼保健院 Kir3dl1基因分型引物组及其应用
WO2021203190A1 (en) * 2020-04-06 2021-10-14 University Health Network Combination therapies for inhibition of polo-like kinase 4
CN115867669A (zh) * 2020-05-08 2023-03-28 凯帝夫肿瘤科技有限公司 监测kras突变的方法
CN111863126B (zh) * 2020-05-28 2024-03-26 上海市生物医药技术研究院 构建结直肠肿瘤状态评估模型的方法及应用
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CN114045339B (zh) * 2021-11-05 2022-06-28 山东第一医科大学附属省立医院(山东省立医院) 铁死亡相关基因在弥漫大b细胞淋巴瘤预后评估中的应用
EP4429773A1 (en) * 2021-11-08 2024-09-18 Albert Einstein College of Medicine Methods, compositions, and kits for modifying immune cell activity via kir2dl5
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