FR2736638B1 - Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2736638B1
FR2736638B1 FR9508423A FR9508423A FR2736638B1 FR 2736638 B1 FR2736638 B1 FR 2736638B1 FR 9508423 A FR9508423 A FR 9508423A FR 9508423 A FR9508423 A FR 9508423A FR 2736638 B1 FR2736638 B1 FR 2736638B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
transferase inhibitors
farnesyl transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9508423A
Other languages
English (en)
Other versions
FR2736638A1 (fr
Inventor
Bernard Baudoin
Christopher Burns
Alain Commercon
Alain Lebrun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to FR9508423A priority Critical patent/FR2736638B1/fr
Priority to ZA965750A priority patent/ZA965750B/xx
Priority to AU65233/96A priority patent/AU6523396A/en
Priority to JP9505563A priority patent/JPH11508911A/ja
Priority to CA002224411A priority patent/CA2224411A1/fr
Priority to PCT/FR1996/001071 priority patent/WO1997003047A1/fr
Priority to EP96924961A priority patent/EP0842150A1/fr
Publication of FR2736638A1 publication Critical patent/FR2736638A1/fr
Application granted granted Critical
Publication of FR2736638B1 publication Critical patent/FR2736638B1/fr
Priority to US09/005,154 priority patent/US5889053A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9508423A 1995-07-12 1995-07-12 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2736638B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR9508423A FR2736638B1 (fr) 1995-07-12 1995-07-12 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
ZA965750A ZA965750B (en) 1995-07-12 1996-07-05 Farnesyl transferase inhibitors their preparation and pharmaceutical composition comprising them
JP9505563A JPH11508911A (ja) 1995-07-12 1996-07-10 新規ファルネシルトランスフェラーゼ阻害剤、それらの製造および該阻害剤を含む医薬組成物
CA002224411A CA2224411A1 (fr) 1995-07-12 1996-07-10 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
AU65233/96A AU6523396A (en) 1995-07-12 1996-07-10 Novel farnesyl transferase inhibitors, preparation thereof and pharmaceutical compositions containing said inhibitors
PCT/FR1996/001071 WO1997003047A1 (fr) 1995-07-12 1996-07-10 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
EP96924961A EP0842150A1 (fr) 1995-07-12 1996-07-10 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
US09/005,154 US5889053A (en) 1995-07-12 1998-01-09 Farnesyl transferase inhibitors, preparation thereof and pharmaceuticals compositions containing said inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508423A FR2736638B1 (fr) 1995-07-12 1995-07-12 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2736638A1 FR2736638A1 (fr) 1997-01-17
FR2736638B1 true FR2736638B1 (fr) 1997-08-22

Family

ID=9480919

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9508423A Expired - Fee Related FR2736638B1 (fr) 1995-07-12 1995-07-12 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (8)

Country Link
US (1) US5889053A (fr)
EP (1) EP0842150A1 (fr)
JP (1) JPH11508911A (fr)
AU (1) AU6523396A (fr)
CA (1) CA2224411A1 (fr)
FR (1) FR2736638B1 (fr)
WO (1) WO1997003047A1 (fr)
ZA (1) ZA965750B (fr)

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WO2014120748A1 (fr) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
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US5705686A (en) * 1993-05-18 1998-01-06 University Of Pittsburgh Inhibition of farnesyl transferase

Also Published As

Publication number Publication date
US5889053A (en) 1999-03-30
JPH11508911A (ja) 1999-08-03
FR2736638A1 (fr) 1997-01-17
ZA965750B (en) 1997-01-27
AU6523396A (en) 1997-02-10
CA2224411A1 (fr) 1997-01-30
WO1997003047A1 (fr) 1997-01-30
EP0842150A1 (fr) 1998-05-20

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