CY1623A - L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same - Google Patents

L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same

Info

Publication number: CY1623A
Authority: CY; Cyprus
Prior art keywords: xylidide; acid; propylpipecolic; preparing; same
Prior art date: 1983-08-01

Application number

CY1623A

Other languages

English (en)

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-01

Filing date

1992-07-10

Publication date

1992-07-10

1992-07-10 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1992-07-10 Publication of CY1623A publication Critical patent/CY1623A/xx

Links

ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 title abstract 3
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
239000003589 local anesthetic agent Substances 0.000 abstract 2
VIVZBHPSVXFBQP-YFKPBYRVSA-N (2s)-piperidine-2-carbonyl chloride Chemical compound ClC(=O)[C@@H]1CCCCN1 VIVZBHPSVXFBQP-YFKPBYRVSA-N 0.000 abstract 1
SILRCGDPZGQJOQ-LBPRGKRZSA-N (S)-2',6'-Pipecoloxylidide Chemical compound CC1=CC=CC(C)=C1NC(=O)[C@H]1NCCCC1 SILRCGDPZGQJOQ-LBPRGKRZSA-N 0.000 abstract 1
UFFBMTHBGFGIHF-UHFFFAOYSA-N 2,6-dimethylaniline Chemical group CC1=CC=CC(C)=C1N UFFBMTHBGFGIHF-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CY1623A 1983-08-01 1992-07-10 L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same CY1623A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/NO1983/000029 WO1985000599A1 (en)	1983-08-01	1983-08-01	L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME

Publications (1)

Publication Number	Publication Date
CY1623A true CY1623A (en)	1992-07-10

Family

ID=19907251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY1623A CY1623A (en)	1983-08-01	1992-07-10	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same

Country Status (12)

Country	Link
EP (1)	EP0151110B1 (de)
JP (1)	JPS60502054A (de)
AT (1)	ATE40994T1 (de)
AU (1)	AU560367B2 (de)
CY (1)	CY1623A (de)
DE (1)	DE3379266D1 (de)
DK (1)	DK153546C (de)
FI (1)	FI80020C (de)
HK (1)	HK98391A (de)
MY (1)	MY101904A (de)
SG (1)	SG87991G (de)
WO (1)	WO1985000599A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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SE451840B (sv) *	1986-01-03	1987-11-02	Astra Laekemedel Ab	Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
PT86249B (pt) *	1987-02-06	1991-02-08	Fisons Corp	Processo de preparacao de derivados de azaciclocarboxamida
US5047541A (en) *	1987-02-06	1991-09-10	Fisons Corporation	2-azacyclocarboxamide derivatives
SE9000288D0 (sv) *	1990-01-26	1990-01-26	Astra Ab	New use
FR2702220B1 (fr) *	1993-03-03	1995-05-12	Synthelabo	Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
SE9302218D0 (sv) *	1993-06-28	1993-06-28	Ab Astra	New use
ES2082703B1 (es) *	1993-11-04	1996-12-16	Inst Investigacion Desarrollo	Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
US5777124A (en) *	1994-10-25	1998-07-07	Chiroscience Limited	Process for preparing levobupivacaine and analogues thereof
GB9504876D0 (en) *	1995-03-10	1995-04-26	Chiroscience Ltd	Compounds and process
SE9501808D0 (sv) *	1995-05-16	1995-05-16	Astra Ab	New process
GB9704351D0 (en) *	1997-03-03	1997-04-23	Chiroscience Ltd	Levobupivacaine and its use
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
SE9800139D0 (sv)	1998-01-21	1998-01-21	Astra Ab	New use
US7247729B2 (en)	2001-09-10	2007-07-24	Mercian Corporation	Method for producing pipecolamide derivative
US7683175B2 (en)	2005-06-06	2010-03-23	Navinta, Llc	Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
ITMI20051144A1 (it) *	2005-06-17	2006-12-18	Molteni & C Dei Fratellei Alit	"procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide"
JP2009535327A (ja) *	2006-04-25	2009-10-01	ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド	ロピバカイン塩酸塩無水物およびその調製
AU2007322033B2 (en)	2006-11-20	2013-07-11	President And Fellows Of Harvard College	Methods, compositions, and kits for treating pain and pruritis
KR100844336B1 (ko) *	2007-01-16	2008-07-07	하나제약 주식회사	레보부피바카인 및 이의 염산염의 신규한 제조방법
US8227114B2 (en)	2007-07-05	2012-07-24	Samsung Sdi Co., Ltd.	Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby
WO2009044404A1 (en) *	2007-10-01	2009-04-09	Ramniwas Goel	Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
WO2009089841A1 (en) *	2008-01-15	2009-07-23	Pharmathen S.A.	Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
JP6205133B2 (ja)	2009-07-10	2017-09-27	プレジデントアンドフェローズオブハーバードカレッジ	抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
RU2504538C2 (ru) *	2012-04-17	2014-01-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России)	2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии
US9108942B1 (en)	2014-11-05	2015-08-18	Mahesh Kandula	Compositions and methods for the treatment of moderate to severe pain
CN103073484B (zh) *	2013-01-28	2014-10-22	山东诚创医药技术开发有限公司	一种甲哌卡因及其光学对映体的制备方法
US9333187B1 (en)	2013-05-15	2016-05-10	Cellix Bio Private Limited	Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en)	2013-06-04	2015-12-30	Cellix Bio Private Ltd	Compositions and methods for the treatment of diabetes and pre-diabetes
CN103304471B (zh) *	2013-07-12	2015-02-04	四川省惠达药业有限公司	一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物
US9096537B1 (en)	2014-12-31	2015-08-04	Mahesh Kandula	Compositions and methods for the treatment of mucositis
NZ736131A (en)	2014-09-26	2019-04-26	Cellix Bio Private Ltd	Compositions and methods for the treatment of epilepsy and neurological disorders
ES2799309T3 (es)	2014-09-29	2020-12-16	Cellix Bio Private Ltd	Compuestos y composiciones para el tratamiento de esclerosis múltiple
US9173877B1 (en) *	2014-11-05	2015-11-03	Cellix Bio Private Limited	Compositions and methods for the treatment of local pain
WO2016088132A1 (en)	2014-12-01	2016-06-09	Cellix Bio Private Limited	Compositions and methods for the treatment of multiple sclerosis
SG11201705524SA (en)	2015-01-06	2017-08-30	Cellix Bio Private Ltd	Compositions and methods for the treatment of inflammation and pain
KR20180069782A (ko)	2015-08-03	2018-06-25	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	하전 이온 채널 블록커 및 이용 방법
US10828287B2 (en)	2019-03-11	2020-11-10	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
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CN114828845A (zh)	2019-11-06	2022-07-29	诺西恩医疗公司	带电的离子通道阻滞剂及其使用方法
US10933055B1 (en)	2019-11-06	2021-03-02	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
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CN119118953A (zh)	2020-03-11	2024-12-13	诺西恩医疗公司	带电的离子通道阻滞剂及其使用方法
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE341404B (de) *	1967-05-18	1971-12-27	Sterling Drug Inc

1983
- 1983-08-01 DE DE8383902297T patent/DE3379266D1/de not_active Expired
- 1983-08-01 AU AU17796/83A patent/AU560367B2/en not_active Expired
- 1983-08-01 AT AT83902297T patent/ATE40994T1/de not_active IP Right Cessation
- 1983-08-01 WO PCT/NO1983/000029 patent/WO1985000599A1/en not_active Ceased
- 1983-08-01 EP EP83902297A patent/EP0151110B1/de not_active Expired
- 1983-08-01 JP JP58502459A patent/JPS60502054A/ja active Granted
1985
- 1985-03-26 DK DK135685A patent/DK153546C/da not_active IP Right Cessation
- 1985-03-29 FI FI851266A patent/FI80020C/fi not_active IP Right Cessation
1987
- 1987-09-28 MY MYPI87001989A patent/MY101904A/en unknown
1991
- 1991-10-22 SG SG879/91A patent/SG87991G/en unknown
- 1991-12-05 HK HK983/91A patent/HK98391A/en not_active IP Right Cessation
1992
- 1992-07-10 CY CY1623A patent/CY1623A/xx unknown

Also Published As

Publication number	Publication date
JPH0559903B2 (de)	1993-09-01
DK135685A (da)	1985-03-26
AU1779683A (en)	1985-03-04
DK153546B (da)	1988-07-25
AU560367B2 (en)	1987-04-02
EP0151110B1 (de)	1989-03-01
DK153546C (da)	1988-12-05
SG87991G (en)	1991-11-22
FI851266L (fi)	1985-03-29
FI80020C (fi)	1990-04-10
FI851266A0 (fi)	1985-03-29
HK98391A (en)	1991-12-13
DK135685D0 (da)	1985-03-26
DE3379266D1 (en)	1989-04-06
EP0151110A1 (de)	1985-08-14
WO1985000599A1 (en)	1985-02-14
JPS60502054A (ja)	1985-11-28
ATE40994T1 (de)	1989-03-15
FI80020B (fi)	1989-12-29
MY101904A (en)	1992-02-15

Publication	Publication Date	Title
DE3379266D1 (en)	1989-04-06	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
MX168599B (es)	1993-06-01	Procedimiento para la preparacion de compuestos cefemicos
BR8500851A (pt)	1985-10-15	Processo para produzir um derivado de benzoilureia e processo para produzir uma composicao inseticida e/ou ovicida
DE3669318D1 (en)	1990-04-12	Alkylresorcinolphosphite.
SE8401398L (sv)	1984-09-15	7-oxabicykloheptansubstituerade prostaglandinanaloger
GR851657B (de)	1985-11-26
FR2514006B1 (de)	1984-12-28
IT8248374A0 (it)	1982-05-10	Procedimento di fermentazione a stadio unico per la preparazione di acido 9-idrossi-3-osso-4,17(20)pregnadien-20-carbossilico, utile come intermedio per la produzionedi steroidi
CA1267150C (en)	1990-03-27	THIABICYCLOHEPTANE SUBSTITUTION DERIVATIVES OF AMINO-PROSTAGLANDIN ANALOGS
MY101645A (en)	1991-12-31	Phosphoric esters and process for preparing the same.
DE3677465D1 (de)	1991-03-14	N-glykolylneuraminsaeurederivat.
ES2026416A6 (es)	1992-04-16	Procedimiento para la preparacion de triazolil-isopropanol.
DE3662785D1 (en)	1989-05-18	Process for the preparation of bromo-fluoro-acetic acid
GB2002350A (en)	1979-02-21	Preparation of tetramisole intermediate
DE3269684D1 (en)	1986-04-10	Process for preparing (thio)hydantoins
ES8505656A1 (es)	1985-06-01	Procedimiento para la preparacion de quinolinonas-4
PT79897A (en)	1985-02-01	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
DE3462035D1 (en)	1987-02-19	Process for the preparation of 4-quinolinones
FI863897L (fi)	1988-03-27	Kemiskt foerfarande.
JPS53124277A (en)	1978-10-30	1-substed-(1,2-diphenylpropyl)piperazines