SG87991G - L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same - Google Patents

L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same

Info

Publication number: SG87991G
Authority: SG; Singapore
Prior art keywords: xylidide; acid; propylpipecolic; preparing; same
Prior art date: 1983-08-01

Application number

SG879/91A

Other languages

English (en)

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-01

Filing date

1991-10-22

Publication date

1991-11-22

1991-10-22 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1991-11-22 Publication of SG87991G publication Critical patent/SG87991G/en

Links

ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 title abstract 3
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
239000003589 local anesthetic agent Substances 0.000 abstract 2
VIVZBHPSVXFBQP-YFKPBYRVSA-N (2s)-piperidine-2-carbonyl chloride Chemical compound ClC(=O)[C@@H]1CCCCN1 VIVZBHPSVXFBQP-YFKPBYRVSA-N 0.000 abstract 1
SILRCGDPZGQJOQ-LBPRGKRZSA-N (S)-2',6'-Pipecoloxylidide Chemical compound CC1=CC=CC(C)=C1NC(=O)[C@H]1NCCCC1 SILRCGDPZGQJOQ-LBPRGKRZSA-N 0.000 abstract 1
UFFBMTHBGFGIHF-UHFFFAOYSA-N 2,6-dimethylaniline Chemical group CC1=CC=CC(C)=C1N UFFBMTHBGFGIHF-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SG879/91A 1983-08-01 1991-10-22 L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same SG87991G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/NO1983/000029 WO1985000599A1 (en)	1983-08-01	1983-08-01	L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME

Publications (1)

Publication Number	Publication Date
SG87991G true SG87991G (en)	1991-11-22

Family

ID=19907251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG879/91A SG87991G (en)	1983-08-01	1991-10-22	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same

Country Status (12)

Country	Link
EP (1)	EP0151110B1 (de)
JP (1)	JPS60502054A (de)
AT (1)	ATE40994T1 (de)
AU (1)	AU560367B2 (de)
CY (1)	CY1623A (de)
DE (1)	DE3379266D1 (de)
DK (1)	DK153546C (de)
FI (1)	FI80020C (de)
HK (1)	HK98391A (de)
MY (1)	MY101904A (de)
SG (1)	SG87991G (de)
WO (1)	WO1985000599A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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SE451840B (sv) *	1986-01-03	1987-11-02	Astra Laekemedel Ab	Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
US5047541A (en) *	1987-02-06	1991-09-10	Fisons Corporation	2-azacyclocarboxamide derivatives
PT86249B (pt) *	1987-02-06	1991-02-08	Fisons Corp	Processo de preparacao de derivados de azaciclocarboxamida
SE9000288D0 (sv) *	1990-01-26	1990-01-26	Astra Ab	New use
FR2702220B1 (fr) *	1993-03-03	1995-05-12	Synthelabo	Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
SE9302218D0 (sv) *	1993-06-28	1993-06-28	Ab Astra	New use
ES2082703B1 (es) *	1993-11-04	1996-12-16	Inst Investigacion Desarrollo	Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
AU694569B2 (en) *	1994-10-25	1998-07-23	Darwin Discovery Limited	Process for preparing levobupivacaine and analogues thereof
GB9504876D0 (en) *	1995-03-10	1995-04-26	Chiroscience Ltd	Compounds and process
SE9501808D0 (sv) *	1995-05-16	1995-05-16	Astra Ab	New process
GB9704351D0 (en) *	1997-03-03	1997-04-23	Chiroscience Ltd	Levobupivacaine and its use
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
SE9800139D0 (sv)	1998-01-21	1998-01-21	Astra Ab	New use
JPWO2003024930A1 (ja) *	2001-09-10	2004-12-24	メルシャン株式会社	ピペコリン酸アミド誘導体の製造方法
US7683175B2 (en)	2005-06-06	2010-03-23	Navinta, Llc	Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
ITMI20051144A1 (it) *	2005-06-17	2006-12-18	Molteni & C Dei Fratellei Alit	"procedimento per la preparazione d'una soluzione iniettabile di (2s)-n-(2;6-dimetil-fenil)-1-propil-2-piperidincarbossiamide"
JP2009535327A (ja) *	2006-04-25	2009-10-01	ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド	ロピバカイン塩酸塩無水物およびその調製
EP2101819B1 (de)	2006-11-20	2013-01-09	President and Fellows of Harvard College	Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis
KR100844336B1 (ko) *	2007-01-16	2008-07-07	하나제약 주식회사	레보부피바카인 및 이의 염산염의 신규한 제조방법
US8227114B2 (en)	2007-07-05	2012-07-24	Samsung Sdi Co., Ltd.	Preparing method of negative active material for non-aqueous electrolyte secondary battery and negative active material prepared thereby
WO2009044404A1 (en) *	2007-10-01	2009-04-09	Ramniwas Goel	Process for the preparation of (s)-ropivacaine hydrochloride monohydrate
ATE555093T1 (de) *	2008-01-15	2012-05-15	Pharmathen Sa	Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
EP2995303A1 (de)	2009-07-10	2016-03-16	President and Fellows of Harvard College	Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel
RU2504538C2 (ru) *	2012-04-17	2014-01-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ПГФА Минздравсоцразвития России)	2,6-диметиланилид n-циклогексилпирролидин-2-карбоновой кислоты гидрохлорид, проявляющий активность при поверхностной, инфильтрационной и проводниковой анестезии
US9108942B1 (en)	2014-11-05	2015-08-18	Mahesh Kandula	Compositions and methods for the treatment of moderate to severe pain
CN103073484B (zh) *	2013-01-28	2014-10-22	山东诚创医药技术开发有限公司	一种甲哌卡因及其光学对映体的制备方法
US9333187B1 (en)	2013-05-15	2016-05-10	Cellix Bio Private Limited	Compositions and methods for the treatment of inflammatory bowel disease
AU2014276346A1 (en)	2013-06-04	2015-12-24	Cellixbio Private Limited	Compositions and methods for the treatment of diabetes and pre-diabetes
CN103304471B (zh) *	2013-07-12	2015-02-04	四川省惠达药业有限公司	一种甲磺酸罗哌卡因化合物、其制备方法及其药物组合物
US9096537B1 (en)	2014-12-31	2015-08-04	Mahesh Kandula	Compositions and methods for the treatment of mucositis
SG11201706952VA (en)	2014-09-26	2017-10-30	Cellix Bio Private Ltd	Compositions and methods for the treatment of epilepsy and neurological disorders
EP3201168B1 (de)	2014-09-29	2020-03-18	Cellix Bio Private Limited	Verbindungen und zusammensetzungen zur behandlung multipler sklerose
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WO2017024037A1 (en)	2015-08-03	2017-02-09	President And Fellows Of Harvard College	Charged ion channel blockers and methods for use
MA55307A (fr)	2019-03-11	2022-01-19	Nocion Therapeutics Inc	Bloqueurs de canaux ioniques chargés et procédés d'utilisation
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JP7708777B2 (ja)	2020-03-11	2025-07-15	ノシオンセラピューティクス，インコーポレイテッド	荷電したイオンチャンネル遮断薬および使用方法
CN112294809B (zh) *	2020-11-20	2022-03-29	四川大学华西医院	一种低毒性局部麻醉药及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE341404B (de) *	1967-05-18	1971-12-27	Sterling Drug Inc

1983
- 1983-08-01 DE DE8383902297T patent/DE3379266D1/de not_active Expired
- 1983-08-01 EP EP83902297A patent/EP0151110B1/de not_active Expired
- 1983-08-01 AT AT83902297T patent/ATE40994T1/de not_active IP Right Cessation
- 1983-08-01 AU AU17796/83A patent/AU560367B2/en not_active Expired
- 1983-08-01 WO PCT/NO1983/000029 patent/WO1985000599A1/en not_active Ceased
- 1983-08-01 JP JP58502459A patent/JPS60502054A/ja active Granted
1985
- 1985-03-26 DK DK135685A patent/DK153546C/da not_active IP Right Cessation
- 1985-03-29 FI FI851266A patent/FI80020C/fi not_active IP Right Cessation
1987
- 1987-09-28 MY MYPI87001989A patent/MY101904A/en unknown
1991
- 1991-10-22 SG SG879/91A patent/SG87991G/en unknown
- 1991-12-05 HK HK983/91A patent/HK98391A/en not_active IP Right Cessation
1992
- 1992-07-10 CY CY1623A patent/CY1623A/xx unknown

Also Published As

Publication number	Publication date
DK153546C (da)	1988-12-05
ATE40994T1 (de)	1989-03-15
WO1985000599A1 (en)	1985-02-14
FI80020B (fi)	1989-12-29
DE3379266D1 (en)	1989-04-06
FI851266A0 (fi)	1985-03-29
DK153546B (da)	1988-07-25
EP0151110B1 (de)	1989-03-01
CY1623A (en)	1992-07-10
JPS60502054A (ja)	1985-11-28
EP0151110A1 (de)	1985-08-14
HK98391A (en)	1991-12-13
FI851266L (fi)	1985-03-29
JPH0559903B2 (de)	1993-09-01
MY101904A (en)	1992-02-15
FI80020C (fi)	1990-04-10
DK135685D0 (da)	1985-03-26
AU560367B2 (en)	1987-04-02
DK135685A (da)	1985-03-26
AU1779683A (en)	1985-03-04

Publication	Publication Date	Title
DE3379266D1 (en)	1989-04-06	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
PT83104A (en)	1986-08-01	Novel guanidinomethylbenzoic acid derivatives
DE3477488D1 (en)	1989-05-03	Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
ES543154A0 (es)	1986-01-01	Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
BR8500851A (pt)	1985-10-15	Processo para produzir um derivado de benzoilureia e processo para produzir uma composicao inseticida e/ou ovicida
DE3669318D1 (en)	1990-04-12	Alkylresorcinolphosphite.
SE8401398L (sv)	1984-09-15	7-oxabicykloheptansubstituerade prostaglandinanaloger
HUT47269A (en)	1989-02-28	Process for production of piperidin-derivatives and medical compositions containing them
YU3099A (sh)	2001-12-26	Novi derivati eritromicina, postupak za njihovo dobijanje i njihova primena
EP0222172A3 (en)	1987-09-02	N-glycolylneuraminic acid derivative
ES2026416A6 (es)	1992-04-16	Procedimiento para la preparacion de triazolil-isopropanol.
FR2370038A1 (fr)	1978-06-02	Derives de l'oxime de l'acide 4-(d-3-amino-3-carboxypropoxy) phenylglyoxylique, constituant la chaine laterale de l'antibiotique nocardicine
DE3662785D1 (en)	1989-05-18	Process for the preparation of bromo-fluoro-acetic acid
GB2002350A (en)	1979-02-21	Preparation of tetramisole intermediate
DE3465737D1 (en)	1987-10-08	Process for the preparation of 4-quinolinones
DE3269684D1 (en)	1986-04-10	Process for preparing (thio)hydantoins
PT79897A (en)	1985-02-01	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
DE3462035D1 (en)	1987-02-19	Process for the preparation of 4-quinolinones
JPS54112847A (en)	1979-09-04	Preparation of novel 3alpha, 6alpha-dihydroxy-24-oxo-5beta-cholestane
JPS53124277A (en)	1978-10-30	1-substed-(1,2-diphenylpropyl)piperazines