CY1653A - Pharmaceutical compositions with analgesic properties and the preparation and use thereof - Google Patents

Pharmaceutical compositions with analgesic properties and the preparation and use thereof Download PDF

Info

Publication number: CY1653A
Authority: CY; Cyprus
Prior art keywords: pharmaceutical composition; composition according; codeine; analgesic; weight ratio
Prior art date: 1985-02-08

Application number

CY1653A

Other languages

English (en)

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-08

Filing date

1993-05-14

Publication date

1993-05-14

1993-05-14 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1993-05-14 Publication of CY1653A publication Critical patent/CY1653A/en

Links

230000000202 analgesic effect Effects 0.000 title claims description 20
239000008194 pharmaceutical composition Substances 0.000 title claims description 14
238000002360 preparation method Methods 0.000 title claims description 10
229960001193 diclofenac sodium Drugs 0.000 claims description 18
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 18
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 16
DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims description 15
229960004415 codeine phosphate Drugs 0.000 claims description 15
238000000034 method Methods 0.000 claims description 9
239000000829 suppository Substances 0.000 claims description 9
229960004126 codeine Drugs 0.000 claims description 8
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
239000002775 capsule Substances 0.000 claims description 7
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 7
229960001259 diclofenac Drugs 0.000 claims description 6
230000003502 anti-nociceptive effect Effects 0.000 claims 3
239000003826 tablet Substances 0.000 description 13
239000003814 drug Substances 0.000 description 9
229940079593 drug Drugs 0.000 description 8
230000000694 effects Effects 0.000 description 8
239000004480 active ingredient Substances 0.000 description 7
238000000576 coating method Methods 0.000 description 7
239000011248 coating agent Substances 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
239000000126 substance Substances 0.000 description 4
108010010803 Gelatin Proteins 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
229940035676 analgesics Drugs 0.000 description 3
239000000730 antalgic agent Substances 0.000 description 3
239000008367 deionised water Substances 0.000 description 3
239000008298 dragée Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 3
229960005301 pentazocine Drugs 0.000 description 3
230000003389 potentiating effect Effects 0.000 description 3
239000000454 talc Substances 0.000 description 3
235000012222 talc Nutrition 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
229920002261 Corn starch Polymers 0.000 description 2
208000002193 Pain Diseases 0.000 description 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000000969 carrier Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003086 colorant Substances 0.000 description 2
239000008120 corn starch Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
239000007942 layered tablet Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000000463 material Substances 0.000 description 2
231100000957 no side effect Toxicity 0.000 description 2
230000036407 pain Effects 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000003381 stabilizer Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000002511 suppository base Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
229920000945 Amylopectin Polymers 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000207199 Citrus Species 0.000 description 1
206010010774 Constipation Diseases 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
206010012335 Dependence Diseases 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
206010052804 Drug tolerance Diseases 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001466453 Laminaria Species 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
208000000114 Pain Threshold Diseases 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
229920003110 Primojel Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
150000005829 chemical entities Chemical class 0.000 description 1
229930002875 chlorophyll Natural products 0.000 description 1
235000019804 chlorophyll Nutrition 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
208000002173 dizziness Diseases 0.000 description 1
239000002702 enteric coating Substances 0.000 description 1
238000009505 enteric coating Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
-1 fatty acid ester Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
239000011888 foil Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000026781 habituation Effects 0.000 description 1
229940116364 hard fat Drugs 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
230000008693 nausea Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229940127240 opiate Drugs 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000037040 pain threshold Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
230000009290 primary effect Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
238000007789 sealing Methods 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000000725 suspension Substances 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CY1653A 1985-02-08 1993-05-14 Pharmaceutical compositions with analgesic properties and the preparation and use thereof CY1653A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH570/85A CH664085A5 (de)	1985-02-08	1985-02-08	Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung.

Publications (1)

Publication Number	Publication Date
CY1653A true CY1653A (en)	1993-05-14

Family

ID=4190060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY1653A CY1653A (en)	1985-02-08	1993-05-14	Pharmaceutical compositions with analgesic properties and the preparation and use thereof

Country Status (18)

Country	Link
US (1)	US4690927A (it)
JP (1)	JPH0729916B2 (it)
BE (1)	BE904196A (it)
CA (1)	CA1255598A (it)
CH (1)	CH664085A5 (it)
CY (1)	CY1653A (it)
DE (1)	DE3603564C2 (it)
FR (1)	FR2577136B1 (it)
GB (1)	GB2170709B (it)
HK (1)	HK80492A (it)
IE (1)	IE58292B1 (it)
IL (1)	IL77780A (it)
IT (1)	IT1208452B (it)
LU (1)	LU86291A1 (it)
NL (1)	NL193440C (it)
PH (1)	PH22920A (it)
SG (1)	SG44592G (it)
ZA (1)	ZA86912B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH675537A5 (it) *	1988-03-25	1990-10-15	Ciba Geigy Ag
SE509029C2 (sv) *	1988-08-16	1998-11-30	Ss Pharmaceutical Co	Långtidsverkande diklofenak-natriumpreparat
TW225536B (it) *	1990-08-23	1994-06-21	Ciba Geigy Ag
US5474985A (en) *	1993-12-22	1995-12-12	The Regents Of The University Of California	Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
DE4403943A1 (de) *	1994-02-08	1995-08-10	Hexal Pharma Gmbh	Orale Azrneimittelzubereitung mit Diclofenac-Natrium
US5674888A (en) *	1995-06-07	1997-10-07	University Of California	Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US5599535A (en) *	1995-06-07	1997-02-04	Regents Of The University Of California	Methods for the cyto-protection of the trabecular meshwork
US6348216B1 (en) *	1996-06-10	2002-02-19	Knoll Pharmaceutical Company	Ibuprofen and narcotic analgesic compositions
US6361794B1 (en)	1996-06-12	2002-03-26	Basf Corporation	Method of making ibuprofen and narcotic analgesic composition
RS49982B (sr)	1997-09-17	2008-09-29	Euro-Celtique S.A.,	Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
US8173164B2 (en) *	1999-06-17	2012-05-08	Gruenenthal Gmbh	Oral administration forms for administering a fixed tramadol and diclofenac combination
CA2504452A1 (en) *	2002-10-31	2004-05-21	Sheryl E. Siegel	Pharmaceutical identification
WO2005027879A1 (en) *	2003-09-24	2005-03-31	Novartis Consumer Health S.A.	Coated tablets
WO2007083985A1 (es) *	2006-01-19	2007-07-26	Farmacéuticos Rayere, S.A.	Composición farmacéutica sinergística de diclofenaco y clonixinato de lisina
EP3417708B1 (en)	2009-03-12	2020-06-17	Cumberland Pharmaceuticals, Inc.	Administration of intravenous ibuprofen
US10765634B2 (en)	2012-01-24	2020-09-08	University of Pittsburgh—of the Commonwealth System of Higher Education	Controlled release formulations for the induction and proliferation of blood cells
US9072710B2 (en)	2012-03-16	2015-07-07	Cumberland Pharmaceuticals Inc.	Injectable ibuprofen formulation
CN108078988B (zh) *	2018-02-13	2019-10-25	山西省太原晋阳制药厂	双氯芬酸钠与磷酸可待因复方缓释组合物及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5283939A (en) *	1976-01-01	1977-07-13	Syntex Inc	Medicine for anodyne
US4126684A (en) *	1976-02-11	1978-11-21	Ciba-Geigy Corporation	4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse
AU528532B2 (en) *	1978-12-18	1983-05-05	Mcniel Laboratories	Acetaminophen analgesic potentiation
US4234601A (en) *	1978-12-18	1980-11-18	Mcneilab, Inc.	Analgesic potentiation
US4233314A (en) *	1978-12-18	1980-11-11	Mcneilab, Inc.	Analgesic potentiation
US4389393A (en) *	1982-03-26	1983-06-21	Forest Laboratories, Inc.	Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
ZA835324B (en) *	1982-07-22	1984-09-26	Abraham Sunshine	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4486436A (en) *	1982-07-22	1984-12-04	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
CH655507B (it) *	1983-01-12	1986-04-30
US4571400A (en) *	1984-12-18	1986-02-18	Belleview Pharmaceutical, Inc.	Dihydrocodeine/ibuprofen pharmaceutical compositions and method
DE3446873A1 (de) *	1984-12-21	1986-07-10	Merckle Gmbh	Fluessige diclofenac-zubereitungen
DE3538142A1 (de) *	1985-10-26	1987-04-30	Hoechst Ag	Kombinationspraeparate aus analgetika und deren verwendung

1985
- 1985-02-08 CH CH570/85A patent/CH664085A5/de not_active IP Right Cessation
1986
- 1986-02-03 IL IL77780A patent/IL77780A/xx not_active IP Right Cessation
- 1986-02-03 US US06/825,293 patent/US4690927A/en not_active Expired - Lifetime
- 1986-02-04 GB GB8602625A patent/GB2170709B/en not_active Expired
- 1986-02-05 PH PH33391A patent/PH22920A/en unknown
- 1986-02-05 LU LU86291A patent/LU86291A1/de unknown
- 1986-02-05 DE DE3603564A patent/DE3603564C2/de not_active Expired - Lifetime
- 1986-02-06 FR FR868601612A patent/FR2577136B1/fr not_active Expired - Lifetime
- 1986-02-06 CA CA000501210A patent/CA1255598A/en not_active Expired
- 1986-02-06 IT IT8647625A patent/IT1208452B/it active
- 1986-02-07 BE BE0/216240A patent/BE904196A/fr not_active IP Right Cessation
- 1986-02-07 JP JP61024243A patent/JPH0729916B2/ja not_active Expired - Lifetime
- 1986-02-07 IE IE35186A patent/IE58292B1/en not_active IP Right Cessation
- 1986-02-07 NL NL8600302A patent/NL193440C/nl not_active IP Right Cessation
- 1986-02-07 ZA ZA86912A patent/ZA86912B/xx unknown
1992
- 1992-04-22 SG SG44592A patent/SG44592G/en unknown
- 1992-10-22 HK HK804/92A patent/HK80492A/xx not_active IP Right Cessation
1993
- 1993-05-14 CY CY1653A patent/CY1653A/en unknown

Also Published As

Publication number	Publication date
IL77780A0 (en)	1986-07-31
DE3603564A1 (de)	1986-08-14
BE904196A (fr)	1986-08-07
IE58292B1 (en)	1993-08-25
GB8602625D0 (en)	1986-03-12
IT1208452B (it)	1989-06-12
US4690927A (en)	1987-09-01
PH22920A (en)	1989-01-24
NL193440B (nl)	1999-07-01
CH664085A5 (de)	1988-02-15
IE860351L (en)	1986-08-08
HK80492A (en)	1992-10-30
LU86291A1 (de)	1986-09-02
IL77780A (en)	1988-05-31
SG44592G (en)	1992-06-12
GB2170709A (en)	1986-08-13
IT8647625A0 (it)	1986-02-06
JPS61183220A (ja)	1986-08-15
GB2170709B (en)	1989-06-07
CA1255598A (en)	1989-06-13
DE3603564C2 (de)	1995-02-02
FR2577136A1 (fr)	1986-08-14
ZA86912B (en)	1986-09-24
FR2577136B1 (fr)	1990-04-20
JPH0729916B2 (ja)	1995-04-05
NL8600302A (nl)	1986-09-01
NL193440C (nl)	1999-11-02

Publication	Publication Date	Title
US4690927A (en)	1987-09-01	Pharmaceutical compositions with analgesic properties and the preparation and use thereof
US4066756A (en)	1978-01-03	Therapeutic compositions of 1,3-bis(2-carboxychromon-5-yloxyl)propan-2-ol and aspirin or indomethacin
US4193985A (en)	1980-03-18	Multiple-units drug dose
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HU230771B1 (hu)	2018-03-28	Késleltetett leadású vitaminkészítmény
JPH0256418A (ja)	1990-02-26	新規医薬製剤およびその製造方法
IE862493L (en)	1987-04-11	Controlled release pharmaceutical preparations
EA014707B1 (ru)	2011-02-28	Новая форма введения рацекадотрила
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IL106743A (en)	1999-11-30	Tablets with improved bioavailability of the active material clodronic acid
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SI9620036B (sl)	2002-10-31	Derivat aminotetralina za terapijo kardiovaskularnih bolezni
CZ79593A3 (en)	1994-01-19	Antitussive preparation
US5077294A (en)	1991-12-31	Products containing verapamil or gallopamil and prazosin
RU2145222C1 (ru)	2000-02-10	Фармацевтическая композиция, обладающая антигистаминным действием
US3495005A (en)	1970-02-10	Compositions and methods for suppressing appetite with combinations of amphetamine and thioridazine
US3491188A (en)	1970-01-20	Pharmaceutical compositions and methods for the treatment of pain with combinations of thioridazine and imipramine,desipramine or pharmaceutically acceptable acid addition salts thereof
BRPI0617184A2 (pt)	2011-07-12	formulação de pralnacasan com liberação retardada
MXPA06014463A (es)	2008-11-26	Composicion farmaceutica que contiene una combinacion de antiespasmodico y analgesico y su uso.
IE46354B1 (en)	1983-05-18	Pharmaceutical mixture containing an anti-inflammatory