CY1664A - Substituted benzamide - Google Patents

Substituted benzamide Download PDF

Info

Publication number: CY1664A
Authority: CY; Cyprus
Prior art keywords: compound; salt; pharmaceutically acceptable; solvate; hydrate
Prior art date: 1987-05-18

Application number

CY1664A

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-18

Filing date

1993-05-14

Publication date

1993-05-14

1993-05-14 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1993-05-14 Publication of CY1664A publication Critical patent/CY1664A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

CY1664A 1987-05-18 1993-05-14 Substituted benzamide CY1664A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/051,880 US4820715A (en)	1984-06-28	1987-05-18	Anti-emetic quinuclidinyl benzamides

Publications (1)

Publication Number	Publication Date
CY1664A true CY1664A (en)	1993-05-14

Family

ID=21973929

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CY1664A CY1664A (en)	1987-05-18	1993-05-14	Substituted benzamide
CY1665A CY1665A (en)	1987-05-18	1993-05-14	Substituted benzamides
CY1662A CY1662A (en)	1987-05-18	1993-05-14	Substituted benzamides

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
CY1665A CY1665A (en)	1987-05-18	1993-05-14	Substituted benzamides
CY1662A CY1662A (en)	1987-05-18	1993-05-14	Substituted benzamides

Country Status (33)

Country	Link
US (1)	US4820715A (de)
JP (1)	JP2502343B2 (de)
KR (1)	KR880013897A (de)
AR (1)	AR245928A1 (de)
AT (1)	AT399338B (de)
AU (2)	AU621287B2 (de)
BE (1)	BE1003571A5 (de)
CA (1)	CA1303616C (de)
CH (1)	CH678852A5 (de)
CS (1)	CS275840B6 (de)
CY (3)	CY1664A (de)
DD (1)	DD274210A5 (de)
DE (1)	DE3816799C2 (de)
DK (1)	DK151988A (de)
ES (1)	ES2009570A6 (de)
FI (1)	FI882233A7 (de)
FR (1)	FR2615512B1 (de)
GB (3)	GB2205095B (de)
GR (1)	GR1000631B (de)
HK (3)	HK72392A (de)
HU (1)	HU201731B (de)
IE (1)	IE60707B1 (de)
IL (1)	IL86244A0 (de)
IT (1)	IT1217573B (de)
LU (1)	LU87173A1 (de)
NL (1)	NL8800683A (de)
NO (1)	NO176273C (de)
PT (1)	PT87470B (de)
SE (2)	SE8801845L (de)
SG (1)	SG80592G (de)
SU (1)	SU1605925A3 (de)
YU (1)	YU46448B (de)
ZA (1)	ZA881966B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820715A (en) *	1984-06-28	1989-04-11	Bristol-Myers Company	Anti-emetic quinuclidinyl benzamides
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
EP0303445A1 (de) *	1987-08-13	1989-02-15	Walton S.A.	Pflaster zur transdermalen Applikation von Cleboprid
JPH02207065A (ja) *	1989-02-07	1990-08-16	Teikoku Chem Ind Corp Ltd	ベンズアミド誘導体
CA2031166A1 (en) *	1989-12-05	1991-06-06	Hans Wynberg	Pyridinium hydrochloride metoclopramide demethylation
US5236931A (en) *	1992-03-26	1993-08-17	A. H. Robins Company, Incorporated	2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
HUT75102A (en) *	1993-06-23	1997-04-28	Chugai Pharmaceutical Co Ltd	Benzene derivatives useful for ischemic diseases and pharmaceutical compositions containing them
JP3235913B2 (ja) *	1993-07-30	2001-12-04	エーザイ株式会社	アミノ安息香酸誘導体
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
BR9811676A (pt) *	1997-07-11	2000-09-19	Janssen Pharmaceutica Nv	(+) norcisaprida útil para distúrbios mediados por 5-ht3 e 5-ht4
SE0002531D0 (sv) *	2000-07-05	2000-07-05	Active Biotech Ab	Immune Enhancement
EP1381603A2 (de)	2000-08-18	2004-01-21	PHARMACIA & UPJOHN COMPANY	Mit aryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden )
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
US7091230B2 (en) *	2001-02-09	2006-08-15	Merck & Co., Inc.	2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
BR0212123A (pt) *	2001-08-24	2004-07-20	Upjohn Co	7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças
JP2005522456A (ja)	2002-02-15	2005-07-28	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1525M (fr) *	1961-07-25	1962-11-16	Ile De France	Médicaments antiémétiques nouveaux.
FR2313935A1 (fr) *	1975-06-10	1977-01-07	Ile De France	Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3966957A (en) *	1972-04-03	1976-06-29	A. H. Robins Company, Incorporated	Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
GB1507462A (en) *	1974-03-21	1978-04-12	Gallardo Antonio Sa	N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
US4189495A (en) *	1974-09-17	1980-02-19	Synthelabo	2-Methoxy-benzamide derivatives
US4039672A (en) *	1975-01-11	1977-08-02	Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France	N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts
US4197243A (en) *	1975-04-02	1980-04-08	Yamanouchi Pharmaceutical Co., Ltd.	N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives
US4093734A (en) *	1975-11-03	1978-06-06	Boehringer Ingelheim Gmbh	Amino-benzoic acid amides
FR2342064A1 (fr) *	1976-02-26	1977-09-23	Andre Buzas	Benzamides 2,5 disubstitues, leurs procedes de preparation et leurs applications therapeutiques
GB1574418A (en) *	1976-11-16	1980-09-03	Anphar Sa	Piperidine derivatives
US4207327A (en) *	1977-08-19	1980-06-10	A. H. Robins Company, Inc.	N-(4-Pyrazolidinyl)benzamides and their amino precursors
EP0067615B1 (de) *	1981-06-17	1986-01-08	Beecham Group Plc	Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CA1183847A (en) *	1981-10-01	1985-03-12	Georges Van Daele	N-(3-hydroxy-4-piperidinyl)benzamide derivatives
JPS5946281A (ja) *	1982-09-09	1984-03-15	Suntory Ltd	１置換ピロリチジン誘導体およびその用途
US4593034A (en) *	1984-04-06	1986-06-03	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4808624A (en) *	1984-06-28	1989-02-28	Bristol-Myers Company	Pharmacologically active substituted benzamides
US4820715A (en) *	1984-06-28	1989-04-11	Bristol-Myers Company	Anti-emetic quinuclidinyl benzamides
US4605652A (en) *	1985-02-04	1986-08-12	A. H. Robins Company, Inc.	Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
EP0385517B1 (de) *	1985-03-14	1993-04-14	BEECHAM GROUP plc	Arzneimittel zur Behandlung von Erbrechen
US4717563A (en) *	1986-03-05	1988-01-05	A. H. Robins Company, Inc.	2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
EP0311724A1 (de) *	1987-10-16	1989-04-19	Synthelabo	Anxiolytische R-N-(1-Azabicyclo[2.2.2]oct-3-yl)-benzamide und -thiobenzamide

1987
- 1987-05-18 US US07/051,880 patent/US4820715A/en not_active Expired - Fee Related
1988
- 1988-03-04 HU HU881057A patent/HU201731B/hu not_active IP Right Cessation
- 1988-03-07 CA CA000560713A patent/CA1303616C/en not_active Expired - Fee Related
- 1988-03-07 CS CS881469A patent/CS275840B6/cs unknown
- 1988-03-10 IE IE70488A patent/IE60707B1/en not_active IP Right Cessation
- 1988-03-11 GB GB8805870A patent/GB2205095B/en not_active Expired - Lifetime
- 1988-03-15 AT AT0069888A patent/AT399338B/de not_active IP Right Cessation
- 1988-03-15 AU AU13115/88A patent/AU621287B2/en not_active Ceased
- 1988-03-18 NO NO881206A patent/NO176273C/no unknown
- 1988-03-18 NL NL8800683A patent/NL8800683A/nl not_active Application Discontinuation
- 1988-03-18 LU LU87173A patent/LU87173A1/fr unknown
- 1988-03-18 DK DK151988A patent/DK151988A/da not_active Application Discontinuation
- 1988-03-18 BE BE8800314A patent/BE1003571A5/fr not_active IP Right Cessation
- 1988-03-18 SU SU884355470A patent/SU1605925A3/ru active
- 1988-03-18 ES ES8800832A patent/ES2009570A6/es not_active Expired
- 1988-03-18 YU YU55588A patent/YU46448B/sh unknown
- 1988-03-18 ZA ZA881966A patent/ZA881966B/xx unknown
- 1988-03-18 FR FR8803568A patent/FR2615512B1/fr not_active Expired - Fee Related
- 1988-03-18 AR AR88310343A patent/AR245928A1/es active
- 1988-03-19 KR KR1019880002961A patent/KR880013897A/ko not_active Ceased
- 1988-03-21 CH CH1067/88A patent/CH678852A5/de not_active IP Right Cessation
- 1988-05-03 IL IL86244A patent/IL86244A0/xx not_active IP Right Cessation
- 1988-05-12 PT PT87470A patent/PT87470B/pt not_active IP Right Cessation
- 1988-05-12 IT IT20550/88A patent/IT1217573B/it active
- 1988-05-12 FI FI882233A patent/FI882233A7/fi not_active IP Right Cessation
- 1988-05-13 JP JP63116744A patent/JP2502343B2/ja not_active Expired - Lifetime
- 1988-05-17 SE SE8801845A patent/SE8801845L/xx not_active Application Discontinuation
- 1988-05-17 DE DE3816799A patent/DE3816799C2/de not_active Expired - Fee Related
- 1988-05-17 SE SE8808452A patent/SE8801845D0/xx unknown
- 1988-05-18 GR GR880100329A patent/GR1000631B/el unknown
- 1988-05-18 DD DD88315874A patent/DD274210A5/de not_active IP Right Cessation
1991
- 1991-06-18 GB GB9113068A patent/GB2243832B/en not_active Expired - Lifetime
- 1991-06-18 GB GB9113070A patent/GB2243833B/en not_active Expired - Lifetime
1992
- 1992-01-20 AU AU10329/92A patent/AU640300B2/en not_active Ceased
- 1992-08-08 SG SG805/92A patent/SG80592G/en unknown
- 1992-09-24 HK HK723/92A patent/HK72392A/xx not_active IP Right Cessation
- 1992-09-24 HK HK725/92A patent/HK72592A/xx not_active IP Right Cessation
- 1992-09-24 HK HK724/92A patent/HK72492A/xx not_active IP Right Cessation
1993
- 1993-05-14 CY CY1664A patent/CY1664A/en unknown
- 1993-05-14 CY CY1665A patent/CY1665A/en unknown
- 1993-05-14 CY CY1662A patent/CY1662A/en unknown

Also Published As

Publication number	Publication date
IT8820550A0 (it)	1988-05-12
CY1662A (en)	1993-05-14
NO176273B (no)	1994-11-28
GB2205095A (en)	1988-11-30
GR1000631B (el)	1992-09-11
IE880704L (en)	1988-11-18
ES2009570A6 (es)	1989-10-01
AU640300B2 (en)	1993-08-19
NL8800683A (nl)	1988-12-16
FR2615512B1 (fr)	1994-02-18
NO881206D0 (no)	1988-03-18
BE1003571A5 (fr)	1992-04-28
IE60707B1 (en)	1994-08-10
ZA881966B (en)	1989-11-29
SE8801845D0 (sv)	1988-05-17
AU1311588A (en)	1988-11-24
GB2243833A (en)	1991-11-13
CS8801469A2 (en)	1990-09-12
SU1605925A3 (ru)	1990-11-07
GB2205095B (en)	1992-02-26
DE3816799A1 (de)	1988-12-08
SG80592G (en)	1992-10-02
HK72592A (en)	1992-10-02
HK72492A (en)	1992-10-02
JP2502343B2 (ja)	1996-05-29
AU621287B2 (en)	1992-03-12
HK72392A (en)	1992-10-02
AU1032992A (en)	1992-03-12
LU87173A1 (fr)	1988-11-17
NO881206L (no)	1988-11-21
SE8801845L (sv)	1988-11-19
YU55588A (en)	1989-08-31
HU201731B (en)	1990-12-28
CS275840B6 (en)	1992-03-18
DK151988D0 (da)	1988-03-18
CA1303616C (en)	1992-06-16
DD274210A5 (de)	1989-12-13
KR880013897A (ko)	1988-12-22
GB9113068D0 (en)	1991-08-07
FI882233A0 (fi)	1988-05-12
NO176273C (no)	1995-03-08
GB2243832B (en)	1992-02-26
DE3816799C2 (de)	1996-07-04
PT87470B (pt)	1992-09-30
YU46448B (sh)	1993-10-20
AT399338B (de)	1995-04-25
CH678852A5 (de)	1991-11-15
US4820715A (en)	1989-04-11
CY1665A (en)	1993-05-14
GB8805870D0 (en)	1988-04-13
AR245928A1 (es)	1994-03-30
GB2243833B (en)	1992-02-26
GB2243832A (en)	1991-11-13
GR880100329A (en)	1989-02-23
GB9113070D0 (en)	1991-08-07
HUT47238A (en)	1989-02-28
JPS63313757A (ja)	1988-12-21
FI882233A7 (fi)	1988-11-19
DK151988A (da)	1988-11-19
IL86244A0 (en)	1988-11-15
IT1217573B (it)	1990-03-30
FR2615512A1 (fr)	1988-11-25
PT87470A (pt)	1989-05-31
ATA69888A (de)	1994-09-15

Publication	Publication Date	Title
US4520025A (en)	1985-05-28	Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
GB2243832A (en)	1991-11-13	2-substituted 4-acetamido-5-chloro-n-[2-(diethylamino)ethyl]-benzamide derivative
GB2140412A (en)	1984-11-28	Thiazolidine derivatives, process for the preparation and pharmaceutical compositions thereof
JPS63295589A (ja)	1988-12-01	生理活性物質ｋ−２５２の誘導体
DD220308A5 (de)	1985-03-27	Verfahren zur herstellung von n(piperidinylalkyl)-carboxamiden
US5679677A (en)	1997-10-21	Heterocyclic carbamates, process for their preparation and medicaments
EP0282547A1 (de)	1988-09-21	Methode zur kontrolle des durch chemotherapeutika verursachten erbrechens und dazu verwendbare, brechreizstillende substanzen.
EP0325406B1 (de)	1993-12-29	Diamin-Verbindungen
EP0570294A1 (de)	1993-11-18	2-Formylpyridin-Thiosemicarbazonderivate, ihre Herstellung und ihre Verwendung als Antitumor Mittel
EP0221511B1 (de)	1992-01-02	2-Aminosulfonyl-6-nitrobenzoesäureester oder Amide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
UA73728C2 (en)	2005-09-15	Derivatives of n-triazolylmethylpiperazine, methods for the preparation thereof, medicament and intermediary compound
EP1973875B1 (de)	2014-06-11	Verbindungen und verfahren zur inhibierung der wechselwirkung von bcl-proteinen mit bindungspartnern
US5049637A (en)	1991-09-17	1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-[1,2-a]azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
Harrold et al.	1989	Synthesis and D2 dopaminergic activity of pyrrolidinium, tetrahydrothiophenium, and tetrahydrothiophene analogs of sulpiride
US4897423A (en)	1990-01-30	Dinitrobenzenesulfonamides
Ram et al.	1984	Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl and aryl ureas
DE60013607T2 (de)	2005-09-29	Bemzimidazolverbindungen und medikamente die diese enthalten
US3887620A (en)	1975-06-03	N-dialkylphosphinylalkyl phenoxyanilines
EP0405905A2 (de)	1991-01-02	Verwendung von Isoxazolin-3-one-Derivaten als Antidepressiva
JPH0680041B2 (ja)	1994-10-12	２−ピリジル酢酸誘導体、その製法およびそれを含む医薬
CH620204A5 (de)	1980-11-14
EP4506346A1 (de)	2025-02-12	Thiobenzimidazolderivat oder pharmazeutisch unbedenkliches salz davon und verwendung davon
US20040038966A1 (en)	2004-02-26	Cyclic amine derivatives and use thereof
EP1351950B1 (de)	2007-08-08	Isochinolin-aroylpyrrole für die behandlung von krankheiten des zentralnervensystems
US4853415A (en)	1989-08-01	2-(substituted sulfamyl) derivatives of 4-nitrobenzamide as radiation sensitizers