CY1728A - Indole derivatives - Google Patents

Indole derivatives Download PDF

Info

Publication number: CY1728A
Authority: CY; Cyprus
Prior art keywords: compound; formula; pharmaceutically acceptable; indole; alkyl group
Prior art date: 1987-08-13

Application number

CY172894A

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-13

Filing date

1994-05-06

Publication date

1994-05-06

1987-08-13 Priority claimed from GB878719167A external-priority patent/GB8719167D0/en

1988-06-14 Priority claimed from GB888814002A external-priority patent/GB8814002D0/en

1988-06-17 Priority claimed from GB888814481A external-priority patent/GB8814481D0/en

1994-05-06 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1994-05-06 Publication of CY1728A publication Critical patent/CY1728A/en

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title description 5
150000002475 indoles Chemical class 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 128
150000003839 salts Chemical class 0.000 claims abstract description 43
238000000034 method Methods 0.000 claims abstract description 30
230000008569 process Effects 0.000 claims abstract description 18
239000012453 solvate Substances 0.000 claims abstract description 18
238000002360 preparation method Methods 0.000 claims abstract description 14
238000011282 treatment Methods 0.000 claims abstract description 13
208000019695 Migraine disease Diseases 0.000 claims abstract description 10
206010027599 migraine Diseases 0.000 claims abstract description 10
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract description 5
206010009094 Chronic paroxysmal hemicrania Diseases 0.000 claims abstract description 4
208000006561 Cluster Headache Diseases 0.000 claims abstract description 4
206010019233 Headaches Diseases 0.000 claims abstract description 4
208000018912 cluster headache syndrome Diseases 0.000 claims abstract description 4
231100000869 headache Toxicity 0.000 claims abstract description 4
208000007777 paroxysmal Hemicrania Diseases 0.000 claims abstract description 4
208000019553 vascular disease Diseases 0.000 claims abstract description 4
239000004480 active ingredient Substances 0.000 claims description 35
238000006243 chemical reaction Methods 0.000 claims description 23
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 13
125000006239 protecting group Chemical group 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
208000002193 Pain Diseases 0.000 claims description 5
150000001412 amines Chemical class 0.000 claims description 4
208000024891 symptom Diseases 0.000 claims description 4
CJTDQTJKWVZIAZ-UHFFFAOYSA-N 2-[3-(1-methylpiperidin-4-yl)-1h-indol-5-yl]ethanesulfonamide Chemical compound C1CN(C)CCC1C1=CNC2=CC=C(CCS(N)(=O)=O)C=C12 CJTDQTJKWVZIAZ-UHFFFAOYSA-N 0.000 claims description 3
125000003342 alkenyl group Chemical group 0.000 claims description 3
238000002560 therapeutic procedure Methods 0.000 claims description 3
239000002552 dosage form Substances 0.000 claims description 2
239000003937 drug carrier Substances 0.000 claims description 2
XPRXJFAFJFZWTC-UHFFFAOYSA-N hoso2 Chemical compound [O]S(O)=O XPRXJFAFJFZWTC-UHFFFAOYSA-N 0.000 claims 1
239000000543 intermediate Substances 0.000 abstract description 18
150000004677 hydrates Chemical class 0.000 abstract description 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 92
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 51
239000000203 mixture Substances 0.000 description 50
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 45
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 39
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 34
235000019441 ethanol Nutrition 0.000 description 31
239000000243 solution Substances 0.000 description 31
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 28
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 26
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 22
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 22
239000007787 solid Substances 0.000 description 21
239000002904 solvent Substances 0.000 description 21
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 20
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 18
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
239000003826 tablet Substances 0.000 description 18
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 16
-1 for example Chemical class 0.000 description 14
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 13
239000002253 acid Substances 0.000 description 13
239000003054 catalyst Substances 0.000 description 13
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
239000000047 product Substances 0.000 description 12
239000000725 suspension Substances 0.000 description 12
230000008570 general process Effects 0.000 description 11
239000000843 powder Substances 0.000 description 11
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
229910021529 ammonia Inorganic materials 0.000 description 10
238000003756 stirring Methods 0.000 description 10
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 9
239000002585 base Substances 0.000 description 9
235000019359 magnesium stearate Nutrition 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
229910000069 nitrogen hydride Inorganic materials 0.000 description 9
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
239000000443 aerosol Substances 0.000 description 8
239000000377 silicon dioxide Substances 0.000 description 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
229960001701 chloroform Drugs 0.000 description 7
239000000706 filtrate Substances 0.000 description 7
239000006260 foam Substances 0.000 description 7
229910052739 hydrogen Inorganic materials 0.000 description 7
239000001257 hydrogen Substances 0.000 description 7
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 7
229910000041 hydrogen chloride Inorganic materials 0.000 description 7
239000008101 lactose Substances 0.000 description 7
229960001375 lactose Drugs 0.000 description 7
229910000029 sodium carbonate Inorganic materials 0.000 description 7
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 7
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 6
239000012346 acetyl chloride Substances 0.000 description 6
239000002775 capsule Substances 0.000 description 6
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 6
230000000694 effects Effects 0.000 description 6
150000002148 esters Chemical class 0.000 description 6
238000003818 flash chromatography Methods 0.000 description 6
150000007522 mineralic acids Chemical class 0.000 description 6
229910052757 nitrogen Inorganic materials 0.000 description 6
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
150000001408 amides Chemical class 0.000 description 5
238000001990 intravenous administration Methods 0.000 description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
GIOZJDZVQIXLKZ-UHFFFAOYSA-N n-ethyl-2-(3-piperidin-4-yl-1h-indol-5-yl)ethanesulfonamide Chemical compound C12=CC(CCS(=O)(=O)NCC)=CC=C2NC=C1C1CCNCC1 GIOZJDZVQIXLKZ-UHFFFAOYSA-N 0.000 description 5
229910052763 palladium Inorganic materials 0.000 description 5
239000003755 preservative agent Substances 0.000 description 5
239000012429 reaction media Substances 0.000 description 5
238000010992 reflux Methods 0.000 description 5
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
239000005526 vasoconstrictor agent Substances 0.000 description 5
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 4
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
229920002472 Starch Polymers 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
239000003377 acid catalyst Substances 0.000 description 4
150000001298 alcohols Chemical class 0.000 description 4
238000007906 compression Methods 0.000 description 4
230000006835 compression Effects 0.000 description 4
JOXWSDNHLSQKCC-UHFFFAOYSA-N ethenesulfonamide Chemical compound NS(=O)(=O)C=C JOXWSDNHLSQKCC-UHFFFAOYSA-N 0.000 description 4
238000001914 filtration Methods 0.000 description 4
238000009472 formulation Methods 0.000 description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
238000001802 infusion Methods 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
150000007524 organic acids Chemical class 0.000 description 4
YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 4
230000002335 preservative effect Effects 0.000 description 4
239000008107 starch Substances 0.000 description 4
229940032147 starch Drugs 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
229910021653 sulphate ion Inorganic materials 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
239000004338 Dichlorodifluoromethane Substances 0.000 description 3
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 3
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 3
235000019759 Maize starch Nutrition 0.000 description 3
229920000388 Polyphosphate Polymers 0.000 description 3
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
229910052783 alkali metal Inorganic materials 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
125000003710 aryl alkyl group Chemical group 0.000 description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
239000003240 coconut oil Substances 0.000 description 3
235000019864 coconut oil Nutrition 0.000 description 3
229940109239 creatinine Drugs 0.000 description 3
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 3
235000019404 dichlorodifluoromethane Nutrition 0.000 description 3
150000002170 ethers Chemical class 0.000 description 3
229940052303 ethers for general anesthesia Drugs 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
235000019634 flavors Nutrition 0.000 description 3
235000003599 food sweetener Nutrition 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 3
239000001205 polyphosphate Substances 0.000 description 3
235000011176 polyphosphates Nutrition 0.000 description 3
239000008213 purified water Substances 0.000 description 3
239000000018 receptor agonist Substances 0.000 description 3
229940044601 receptor agonist Drugs 0.000 description 3
239000012312 sodium hydride Substances 0.000 description 3
229910000104 sodium hydride Inorganic materials 0.000 description 3
239000000829 suppository Substances 0.000 description 3
239000003765 sweetening agent Substances 0.000 description 3
239000006188 syrup Substances 0.000 description 3
235000020357 syrup Nutrition 0.000 description 3
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
HUUPVABNAQUEJW-UHFFFAOYSA-N 1-methylpiperidin-4-one Chemical compound CN1CCC(=O)CC1 HUUPVABNAQUEJW-UHFFFAOYSA-N 0.000 description 2
VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 description 2
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
VXWVFZFZYXOBTA-UHFFFAOYSA-N 5-bromo-1h-indole Chemical compound BrC1=CC=C2NC=CC2=C1 VXWVFZFZYXOBTA-UHFFFAOYSA-N 0.000 description 2
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
239000005642 Oleic acid Substances 0.000 description 2
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
125000002252 acyl group Chemical group 0.000 description 2
239000003513 alkali Substances 0.000 description 2
229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
150000008041 alkali metal carbonates Chemical class 0.000 description 2
229910000102 alkali metal hydride Inorganic materials 0.000 description 2
150000008046 alkali metal hydrides Chemical class 0.000 description 2
150000001350 alkyl halides Chemical class 0.000 description 2
238000005804 alkylation reaction Methods 0.000 description 2
229960004977 anhydrous lactose Drugs 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
238000009903 catalytic hydrogenation reaction Methods 0.000 description 2
238000009833 condensation Methods 0.000 description 2
230000005494 condensation Effects 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000010511 deprotection reaction Methods 0.000 description 2
229960004132 diethyl ether Drugs 0.000 description 2
UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 2
OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 2
229960004943 ergotamine Drugs 0.000 description 2
XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 2
HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000010419 fine particle Substances 0.000 description 2
239000012530 fluid Substances 0.000 description 2
239000012458 free base Substances 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
150000007857 hydrazones Chemical class 0.000 description 2
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
239000000463 material Substances 0.000 description 2
GSYSFVSGPABNNL-UHFFFAOYSA-N methyl 2-dimethoxyphosphoryl-2-(phenylmethoxycarbonylamino)acetate Chemical group COC(=O)C(P(=O)(OC)OC)NC(=O)OCC1=CC=CC=C1 GSYSFVSGPABNNL-UHFFFAOYSA-N 0.000 description 2
239000013081 microcrystal Substances 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
AMKVXSZCKVJAGH-UHFFFAOYSA-N naratriptan Chemical compound C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCN(C)CC1 AMKVXSZCKVJAGH-UHFFFAOYSA-N 0.000 description 2
150000002825 nitriles Chemical class 0.000 description 2
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 2
150000002940 palladium Chemical class 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
239000012071 phase Substances 0.000 description 2
229910000073 phosphorus hydride Inorganic materials 0.000 description 2
229910003446 platinum oxide Inorganic materials 0.000 description 2
229920000137 polyphosphoric acid Polymers 0.000 description 2
BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
238000011946 reduction process Methods 0.000 description 2
238000002390 rotary evaporation Methods 0.000 description 2
239000000741 silica gel Substances 0.000 description 2
229910002027 silica gel Inorganic materials 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
239000007921 spray Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000375 suspending agent Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
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SZXQDMYFSIGZHY-UHFFFAOYSA-N n-methyl-2-(3-piperidin-4-yl-1h-indol-5-yl)ethanesulfonamide;hydrochloride Chemical compound Cl.C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCNCC1 SZXQDMYFSIGZHY-UHFFFAOYSA-N 0.000 description 1
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XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000011369 resultant mixture Substances 0.000 description 1
229910052703 rhodium Inorganic materials 0.000 description 1
239000010948 rhodium Substances 0.000 description 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
QBERHIJABFXGRZ-UHFFFAOYSA-M rhodium;triphenylphosphane;chloride Chemical compound [Cl-].[Rh].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 QBERHIJABFXGRZ-UHFFFAOYSA-M 0.000 description 1
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ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
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230000003019 stabilising effect Effects 0.000 description 1
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FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
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YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CY172894A 1987-08-13 1994-05-06 Indole derivatives CY1728A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB878719167A GB8719167D0 (en)	1987-08-13	1987-08-13	Chemical compounds
GB888814002A GB8814002D0 (en)	1988-06-14	1988-06-14	Chemical compounds
GB888814481A GB8814481D0 (en)	1988-06-17	1988-06-17	Chemical compounds
GB8819200A GB2208646B (en)	1987-08-13	1988-08-12	Indole derivatives

Publications (1)

Publication Number	Publication Date
CY1728A true CY1728A (en)	1994-05-06

Family

ID=27263551

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY172894A CY1728A (en)	1987-08-13	1994-05-06	Indole derivatives

Country Status (28)

Country	Link
US (1)	US4997841A (da)
EP (1)	EP0303507B1 (da)
JP (1)	JPH0633252B2 (da)
KR (1)	KR0131327B1 (da)
AT (1)	ATE92057T1 (da)
AU (1)	AU611469B2 (da)
CA (1)	CA1310968C (da)
CY (1)	CY1728A (da)
CZ (1)	CZ404291A3 (da)
DE (2)	DE3882614T2 (da)
DK (1)	DK172696B1 (da)
ES (1)	ES2058292T3 (da)
FI (1)	FI92397C (da)
GB (1)	GB2208646B (da)
HK (1)	HK86793A (da)
HU (1)	HU211576A9 (da)
IE (1)	IE61488B1 (da)
IL (1)	IL87437A0 (da)
LU (1)	LU90160I2 (da)
LV (1)	LV5736B4 (da)
NL (1)	NL970035I2 (da)
NO (2)	NO174052C (da)
NZ (1)	NZ225820A (da)
PH (1)	PH24976A (da)
PT (1)	PT88255B (da)
SG (1)	SG65393G (da)
SK (1)	SK281495B6 (da)
UY (1)	UY23657A1 (da)

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GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
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CZ288351B6 (en) *	1990-06-07	2001-05-16	Astrazeneca Ab	Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives
NZ243065A (en)	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
TW222631B (da) *	1991-07-15	1994-04-21	Duphar Int Res
GB9209882D0 (en) *	1992-05-07	1992-06-24	Glaxo Lab Sa	Compositions
GB9211277D0 (en)	1992-05-28	1992-07-15	Glaxo Group Inc	Pharmaceutical compositions
AU675964B2 (en) *	1992-08-05	1997-02-27	John Wyeth & Brother Limited	Amide derivatives
GB9320115D0 (en) *	1993-09-29	1993-11-17	Glaxo Group Ltd	Process
US5521196A (en) *	1994-10-05	1996-05-28	Eli Lilly And Company	5-HT1F agonists for the treatment of migraine
US5521197A (en) *	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
FR2731222A1 (fr) *	1995-03-02	1996-09-06	Pf Medicament	Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments
FR2731224B1 (fr) *	1995-03-02	1997-05-30	Pf Medicament	Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
KR19980703048A (ko) *	1995-03-20	1998-09-05	피터쥐.스트링거	5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
AU2104097A (en) *	1996-03-13	1997-10-01	Glaxo Group Limited	Medicaments comprising 5ht1-like receptor agonists with an increased absorption
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
US6066092A (en) *	1997-11-06	2000-05-23	Cady; Roger K.	Preemptive prophylaxis of migraine device and method
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
MXPA02012927A (es) *	2000-07-21	2003-05-15	Lundbeck & Co As H	Derivados de indol utiles para el tratamiento de padecimientos del sistema nervioso central.
WO2002044159A2 (en) *	2000-11-29	2002-06-06	Eli Lilly And Company	1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence
US8329734B2 (en)	2009-07-27	2012-12-11	Afgin Pharma Llc	Topical therapy for migraine
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
EP1644004A4 (en)	2003-06-20	2010-10-06	Ronald Aung-Din	LOCAL THERAPY FOR THE TREATMENT OF MIGRAINS, MUSCLE CLARIFICATIONS, MUSCLE SPASMS, SPASTICITY AND RELATED CONDITIONS
PL1814538T3 (pl) *	2004-11-24	2010-02-26	Alcon Inc	Sposób dostarczania donosowego sprayu
WO2008049116A2 (en) *	2006-10-19	2008-04-24	Auspex Pharmaceuticals, Inc.	Substituted indoles
WO2008056378A2 (en) *	2006-11-09	2008-05-15	Natco Pharma Limited	Novel process for the preparation of naratriptan hydrochloride
WO2008072257A2 (en) *	2006-12-12	2008-06-19	Ind-Swift Laboratories Limited	Process for the preparation of indole derivatives
WO2009016466A2 (en) *	2007-07-30	2009-02-05	Orchid Chemicals & Pharmaceuticals Limited	A process for the preparation of naratriptan hydrochloride
WO2009118753A2 (en) *	2008-03-07	2009-10-01	Usv Limited	Process for preparation of naratriptan hydrochloride
CA2729346A1 (en)	2008-06-30	2010-01-14	Afgin Pharma, Llc	Topical regional neuro-affective therapy
WO2010004580A2 (en) *	2008-07-11	2010-01-14	Ind-Swift Laboratories Limited	Process for preparing indole derivatives
WO2010084507A2 (en) *	2008-07-15	2010-07-29	Sun Pharmaceutical Industries Ltd.	Process for the preparation of n-methyl-2-[3-(1-methyl-4-piperidyl)-1h-indol-5-yl]-ethanesulfonamide and its acid addition salts
US8735589B2 (en)	2009-08-20	2014-05-27	Cipla Limited	Process for the synthesis of naratriptan
CN102276581B (zh) *	2011-08-05	2013-06-12	上海师范大学	N-取代四氢吡啶连吲哚类化合物及其制备方法及应用
US10383816B2 (en)	2015-03-02	2019-08-20	Afgin Pharma, Llc	Topical regional neuro-affective therapy with cannabinoid combination products
BR112017018944A2 (en)	2015-03-02	2018-05-15	Afgin Pharma, Llc	method of treating a disease state or condition in humans with a carbinoid drug, and method of treating a disease state or condition in a mammal other than a human with carbinoid drug (s)
US20180049994A1 (en)	2016-08-16	2018-02-22	Afgin Pharma, Llc	Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (en)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Orodispersible powder composition comprising a triptan

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FR2362628A1 (fr) *	1976-08-26	1978-03-24	Roussel Uclaf	Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) *	1978-01-16	1979-11-02	Roussel Uclaf	Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
GR79215B (da) *	1982-06-07	1984-10-22	Glaxo Group Ltd
FR2533924A1 (fr) *	1982-10-05	1984-04-06	Roussel Uclaf	Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
GB8332437D0 (en) *	1983-12-06	1984-01-11	Glaxo Group Ltd	Chemical compounds
GB8332435D0 (en) *	1983-12-06	1984-01-11	Glaxo Group Ltd	Chemical compounds
DE3419935A1 (de) *	1984-05-28	1985-11-28	Merck Patent Gmbh, 6100 Darmstadt	Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
GB2162522B (en) *	1984-08-01	1988-02-24	Glaxo Group Ltd	An indole derivative
US4548939A (en) *	1984-10-01	1985-10-22	Janssen Pharmaceutica N. V.	1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4785016A (en) *	1984-12-04	1988-11-15	Glaxo Group Limited	Indole derivatives
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
GB8903036D0 (en) *	1989-02-10	1989-03-30	Glaxo Group Ltd	Chemical compounds

1988
- 1988-08-12 PH PH37409A patent/PH24976A/en unknown
- 1988-08-12 ES ES88307499T patent/ES2058292T3/es not_active Expired - Lifetime
- 1988-08-12 JP JP63201839A patent/JPH0633252B2/ja not_active Expired - Lifetime
- 1988-08-12 IE IE247788A patent/IE61488B1/en not_active IP Right Cessation
- 1988-08-12 IL IL87437A patent/IL87437A0/xx not_active IP Right Cessation
- 1988-08-12 US US07/231,274 patent/US4997841A/en not_active Expired - Lifetime
- 1988-08-12 KR KR88010367A patent/KR0131327B1/ko not_active Expired - Lifetime
- 1988-08-12 EP EP88307499A patent/EP0303507B1/en not_active Expired - Lifetime
- 1988-08-12 FI FI883744A patent/FI92397C/fi not_active IP Right Cessation
- 1988-08-12 NZ NZ225820A patent/NZ225820A/xx unknown
- 1988-08-12 DE DE88307499T patent/DE3882614T2/de not_active Expired - Lifetime
- 1988-08-12 NO NO883587A patent/NO174052C/no not_active IP Right Cessation
- 1988-08-12 AT AT88307499T patent/ATE92057T1/de active
- 1988-08-12 AU AU20692/88A patent/AU611469B2/en not_active Expired
- 1988-08-12 GB GB8819200A patent/GB2208646B/en not_active Expired - Lifetime
- 1988-08-12 DK DK198804554A patent/DK172696B1/da not_active IP Right Cessation
- 1988-08-12 CA CA000574643A patent/CA1310968C/en not_active Expired - Lifetime
- 1988-08-12 PT PT88255A patent/PT88255B/pt not_active IP Right Cessation
- 1988-08-13 SK SK4042-91A patent/SK281495B6/sk unknown
1991
- 1991-12-23 CZ CS914042A patent/CZ404291A3/cs unknown
1993
- 1993-05-19 SG SG653/93A patent/SG65393G/en unknown
- 1993-08-19 HK HK867/93A patent/HK86793A/xx not_active IP Right Cessation
- 1993-09-23 UY UY23657A patent/UY23657A1/es not_active IP Right Cessation
1994
- 1994-05-06 CY CY172894A patent/CY1728A/en unknown
1995
- 1995-06-30 HU HU95P/P00631P patent/HU211576A9/hu unknown
- 1995-12-14 LV LV950371A patent/LV5736B4/xx unknown
1997
- 1997-09-10 NL NL970035C patent/NL970035I2/nl unknown
- 1997-10-31 LU LU90160C patent/LU90160I2/fr unknown
1998
- 1998-02-05 NO NO1998008C patent/NO1998008I1/no unknown
- 1998-08-12 DE DE19983883614 patent/DE19775082I2/de active Active

Also Published As

Publication number	Publication date
CZ404291A3 (en)	1993-04-14
LV5736B4 (lv)	1997-06-20
SK404291A3 (en)	2000-09-12
JPH0633252B2 (ja)	1994-05-02
AU2069288A (en)	1989-02-16
KR890003731A (ko)	1989-04-17
PT88255A (pt)	1989-06-30
IE882477L (en)	1989-02-13
DE3882614D1 (de)	1993-09-02
GB2208646A (en)	1989-04-12
DK455488A (da)	1989-02-14
DK172696B1 (da)	1999-05-31
NO174052B (no)	1993-11-29
NO883587D0 (no)	1988-08-12
EP0303507A3 (en)	1990-09-19
DE3882614T2 (de)	1993-11-18
KR0131327B1 (en)	1998-04-17
LV5736A4 (lv)	1996-06-20
GB2208646B (en)	1991-06-26
CA1310968C (en)	1992-12-01
FI92397C (fi)	1994-11-10
EP0303507A2 (en)	1989-02-15
FI92397B (fi)	1994-07-29
HK86793A (en)	1993-08-27
PH24976A (en)	1990-12-26
NO1998008I1 (no)	1998-02-05
NO174052C (no)	1994-03-09
PT88255B (pt)	1995-03-01
IL87437A0 (en)	1989-01-31
DK455488D0 (da)	1988-08-12
LU90160I2 (fr)	1998-01-14
ES2058292T3 (es)	1994-11-01
US4997841A (en)	1991-03-05
FI883744L (fi)	1989-02-14
SK281495B6 (sk)	2001-04-09
NL970035I2 (nl)	1998-01-05
FI883744A0 (fi)	1988-08-12
NZ225820A (en)	1990-09-26
GB8819200D0 (en)	1988-09-14
AU611469B2 (en)	1991-06-13
ATE92057T1 (de)	1993-08-15
UY23657A1 (es)	1994-02-25
EP0303507B1 (en)	1993-07-28
JPH01207288A (ja)	1989-08-21
IE61488B1 (en)	1994-11-02
NL970035I1 (nl)	1997-11-03
HU211576A9 (en)	1995-12-28
DE19775082I2 (de)	2006-04-27
NO883587L (no)	1989-02-14
SG65393G (en)	1993-08-06

Publication	Publication Date	Title
US4997841A (en)	1991-03-05	Indole derivatives
US5036078A (en)	1991-07-30	Piperidinyl indoles for migraine treatment
US5066660A (en)	1991-11-19	Indole derivatives
US4816470A (en)	1989-03-28	Heterocyclic compounds
US5475020A (en)	1995-12-12	Indolyl compounds and their use in treatment of cephalic pain
US5045545A (en)	1991-09-03	[(Imidazol-4(and 5)-yl)methyl] tetracyclic ketones having 5-HT3 antagonist activity
US4950681A (en)	1990-08-21	Ketone derivatives
US5026722A (en)	1991-06-25	Indole derivatives
US5001135A (en)	1991-03-19	Indole derivatives
US5494910A (en)	1996-02-27	Benzofuran derivatives as 5-HT1 -like receptor antagonists
US5008272A (en)	1991-04-16	Lactam derivatives
US4963546A (en)	1990-10-16	Ketone derivatives which are antagonists of 5-HT at 5-HT3 receptors, compositions containing them, and method of use
US5770611A (en)	1998-06-23	Indole derivatives as 5HT1 -like agonists
EP0345956B1 (en)	1994-03-16	Tricyclic ketones
HU202225B (en)	1991-02-28	Process for producing indole derivatives